Polycystin-1 and polycystin-2 regulate the cell cycle through the helix–loop–helix inhibitor Id2

[1]  H. Kurooka,et al.  Nucleo-cytoplasmic Shuttling of Id2, a Negative Regulator of Basic Helix-Loop-Helix Transcription Factors* , 2005, Journal of Biological Chemistry.

[2]  K. Miyazono,et al.  A role for Id in the regulation of TGF-β-induced epithelial–mesenchymal transdifferentiation , 2004, Cell Death and Differentiation.

[3]  C. Heldin,et al.  Id2 and Id3 Define the Potency of Cell Proliferation and Differentiation Responses to Transforming Growth Factor β and Bone Morphogenetic Protein , 2004, Molecular and Cellular Biology.

[4]  S. Nauli,et al.  Gating of the polycystin ion channel signaling complex in neurons and kidney cells , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  Jing Zhou,et al.  Native Polycystin 2 Functions as a Plasma Membrane Ca2+-Permeable Cation Channel in Renal Epithelia , 2003, Molecular and Cellular Biology.

[6]  Jing Zhou,et al.  Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells , 2003, Nature Genetics.

[7]  Lei Guo,et al.  Polycystin-2 associates with tropomyosin-1, an actin microfilament component. , 2003, Journal of molecular biology.

[8]  Guan-qing Wu,et al.  Polycystin-2 interacts with troponin I, an angiogenesis inhibitor. , 2003, Biochemistry.

[9]  Jing Zhou,et al.  Molecular Complexes Formed with Polycystins , 2003, Nephron Experimental Nephrology.

[10]  G. Wolf,et al.  The Renin-Angiotensin System and Progression of Renal Disease: From Hemodynamics to Cell Biology , 2002, Nephron Physiology.

[11]  James P Calvet,et al.  Polycystin-1 Activation of c-Jun N-terminal Kinase and AP-1 Is Mediated by Heterotrimeric G Proteins* , 2002, The Journal of Biological Chemistry.

[12]  Alessandra Boletta,et al.  PKD1 Induces p21waf1 and Regulation of the Cell Cycle via Direct Activation of the JAK-STAT Signaling Pathway in a Process Requiring PKD2 , 2002, Cell.

[13]  Jing Zhou,et al.  Constitutive Activation of G-proteins by Polycystin-1 Is Antagonized by Polycystin-2* , 2002, The Journal of Biological Chemistry.

[14]  C. McNamara,et al.  Contribution of the Helix-Loop-Helix Factor Id2 to Regulation of Vascular Smooth Muscle Cell Proliferation* , 2002, The Journal of Biological Chemistry.

[15]  S. Somlo,et al.  Polycystin-2 is an intracellular calcium release channel , 2002, Nature Cell Biology.

[16]  C. Stayner,et al.  Polycystin channels and kidney disease. , 2001, Trends in pharmacological sciences.

[17]  P. Harris,et al.  Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. , 2001, Human molecular genetics.

[18]  Wayne A. Phillips,et al.  Id2 Is a Target of the β-Catenin/T Cell Factor Pathway in Colon Carcinoma* , 2001, The Journal of Biological Chemistry.

[19]  J. Grantham,et al.  Polycystic kidney disease: from the bedside to the gene and back , 2001, Current opinion in nephrology and hypertension.

[20]  E. Brown,et al.  Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease. , 2001, Biochemical and biophysical research communications.

[21]  A. Iavarone,et al.  Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins , 2000, Nature.

[22]  L. Lania,et al.  Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth. , 2000, Cancer research.

[23]  Thierry Arnould,et al.  The Polycystic Kidney Disease 1 Gene Product Modulates Wnt Signaling* , 1999, The Journal of Biological Chemistry.

[24]  A. Sparks,et al.  Identification of c-MYC as a target of the APC pathway. , 1998, Science.

[25]  R. Kucherlapati,et al.  Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease , 1998, Cell.

[26]  V. D’Agati,et al.  C-MYC–induced Apoptosis in Polycystic Kidney Disease Is Bcl-2 and p53 Independent , 1997, The Journal of experimental medicine.

[27]  Weining Lu,et al.  Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation , 1997, Nature Genetics.

[28]  S. T. Park,et al.  Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins , 1997, Molecular and cellular biology.

[29]  V. Sukhatme,et al.  Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[30]  G. Germino,et al.  PKD1 interacts with PKD2 through a probable coiled-coil domain , 1997, Nature Genetics.

[31]  P. Wilson Epithelial cell polarity and disease. , 1997, The American journal of physiology.

[32]  G. Peters,et al.  Cdk2‐dependent phosphorylation of Id2 modulates activity of E2A‐related transcription factors , 1997, The EMBO journal.

[33]  G. Germino,et al.  The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I , 1996, Cell.

[34]  J D Norton,et al.  Attenuated function of a variant form of the helix‐loop‐helix protein, Id‐3, generated by an alternative splicing mechanism , 1996, FEBS letters.

[35]  K. Georgopoulos,et al.  A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma , 1995, Cell.

[36]  J. Hughes,et al.  The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains , 1995, Nature Genetics.

[37]  P. Bork,et al.  Polycystic kidney disease: The complete structure of the PKD1 gene and its protein , 1995, Cell.

[38]  R. Pepperkok,et al.  Regulation of G1 progression by E2A and Id helix‐loop‐helix proteins. , 1994, The EMBO journal.

[39]  J. Calvet Injury and development in polycystic kidney disease. , 1994, Current opinion in nephrology and hypertension.

[40]  P. Gabow Introduction: Autosomal Dominant Polycystic Kidney Disease , 1993 .

[41]  J. Grantham 1992 Homer Smith Award. Fluid secretion, cellular proliferation, and the pathogenesis of renal epithelial cysts. , 1993, Journal of the American Society of Nephrology : JASN.

[42]  S. Reeders Multilocus polycystic disease , 1992, Nature Genetics.

[43]  Y. Jan,et al.  Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence , 1989, Cell.

[44]  S. Fields,et al.  A novel genetic system to detect protein–protein interactions , 1989, Nature.

[45]  H. Cantiello,et al.  Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[46]  V. D’Agati,et al.  Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression. , 1998, The American journal of pathology.

[47]  K. Blick,et al.  Proliferative activity of cyst epithelium in human renal cystic diseases. , 1995, Journal of the American Society of Nephrology.