Cellular Biology Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca Crosstalk

decreased cardiomyocyte SR-mitochondrial contact length by 30% and reduced the content of SR-associated proteins in mitochondria-associated membranes. This was associated with decreased mitochondrial Ca uptake (despite unchanged mitochondrial membrane potential) but increased steady-state and caffeine-induced SR Ca release. Accordingly, Ca -induced stimulation of Krebs cycle dehydrogenases during -adrenergic stimulation

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