Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II‐induced microcirculatory changes in a model of primary hypertension

We investigated the acute effects of SIM on cerebral microvascular rarefaction and dysfunction in SHRs.

[1]  Bin-Nan Wu,et al.  Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho‐kinase pathway and NADPH oxidase , 2017, Pediatric pulmonology.

[2]  P. Bousquet,et al.  Cerebral Microvascular Dysfunction and Inflammation Are Improved by Centrally Acting Antihypertensive Drugs in Metabolic Syndrome. , 2017, Metabolic Syndrome and Related Disorders.

[3]  F. Verdonk,et al.  Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction , 2017, Brain, Behavior, and Immunity.

[4]  M. Machado,et al.  Exercise Training Reverses Structural Microvascular Rarefaction and Improves Endothelium-Dependent Microvascular Reactivity in Rats with Diabetes. , 2016, Metabolic syndrome and related disorders.

[5]  David A Boas,et al.  Sensitivity of laser speckle contrast imaging to flow perturbations in the cortex. , 2016, Biomedical optics express.

[6]  A. Cai,et al.  Rho-GTPase and Atherosclerosis: Pleiotropic Effects of Statins , 2015, Journal of the American Heart Association.

[7]  X. Tong,et al.  Simvastatin Restored Vascular Reactivity, Endothelial Function and Reduced String Vessel Pathology in a Mouse Model of Cerebrovascular Disease , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  S. Bertolini,et al.  Lipoproteins, stroke and statins. , 2014, Current vascular pharmacology.

[9]  A. Villringer.  The path from obesity and hypertension to dementia. , 2015, Advances in experimental medicine and biology.

[10]  J. Nilsson,et al.  Non-invasive imaging of microcirculation: a technology review , 2014, Medical devices.

[11]  P. Barter,et al.  Antioxidant effects of statins in the management of cardiometabolic disorders. , 2014, Journal of atherosclerosis and thrombosis.

[12]  Andrew K Dunn,et al.  Imaging depth and multiple scattering in laser speckle contrast imaging , 2014, Journal of biomedical optics.

[13]  M. Sikora,et al.  Statins, the renin–angiotensin–aldosterone system and hypertension – a tale of another beneficial effect of statins , 2014, Journal of the renin-angiotensin-aldosterone system : JRAAS.

[14]  Andrew K Dunn,et al.  Optimization of camera exposure durations for multi-exposure speckle imaging of the microcirculation. , 2014, Biomedical optics express.

[15]  H. Castro-Faria-Neto,et al.  Acute Chagas Disease Induces Cerebral Microvasculopathy in Mice , 2014, PLoS neglected tropical diseases.

[16]  E. Tibiriçá,et al.  Impairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imaging , 2014, Coronary artery disease.

[17]  E. Tibirica,et al.  Cardiac Microvascular Rarefaction in Hyperthyroidism‐Induced Left Ventricle Dysfunction , 2013, Microcirculation.

[18]  M. Horiuchi,et al.  Protective arms of the renin–angiotensin‐system in neurological disease , 2013, Clinical and experimental pharmacology & physiology.

[19]  E. Tibiriçá,et al.  Blockade of the renin-angiotensin system improves cerebral microcirculatory perfusion in diabetic hypertensive rats. , 2013, Microvascular research.

[20]  F. Messerli,et al.  Antihypertensive Effects of Statins: A Meta‐Analysis of Prospective Controlled Studies , 2013, Journal of clinical hypertension.

[21]  M. Bonini,et al.  Effects of angiotensin II on the cerebral circulation: role of oxidative stress , 2012, Front. Physio..

[22]  L. Pernomian,et al.  Contribution of oxidative stress to endothelial dysfunction in hypertension , 2012, Front. Physio..

[23]  G. Zimmerman,et al.  Statins Decrease Neuroinflammation and Prevent Cognitive Impairment after Cerebral Malaria , 2012, PLoS pathogens.

[24]  A. Al-Asmari,et al.  Simvastatin Attenuates Contrast-Induced Nephropathy through Modulation of Oxidative Stress, Proinflammatory Myeloperoxidase, and Nitric Oxide , 2012, Oxidative medicine and cellular longevity.

[25]  R. Carey,et al.  AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function , 2012, Pflügers Archiv - European Journal of Physiology.

[26]  Ivan Cordovil,et al.  Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging. , 2012, Microvascular research.

[27]  Jun-xia Jiang,et al.  Simvastatin delivery via inhalation attenuates airway inflammation in a murine model of asthma. , 2012, International immunopharmacology.

[28]  M. Wareing,et al.  Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries , 2011, Clinical science.

[29]  Anthony J. Durkin,et al.  Laser speckle imaging in the spatial frequency domain , 2010, Biomedical optics express.

[30]  Fang Gao,et al.  The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats. , 2010, International journal of pharmaceutics.

[31]  J. Farmer,et al.  Statins as Adjunctive Therapy in the Management of Hypertension , 2010, Current atherosclerosis reports.

[32]  J. Liao,et al.  Pleiotropic effects of statins. - Basic research and clinical perspectives -. , 2010, Circulation journal : official journal of the Japanese Circulation Society.

[33]  M. Safar,et al.  Cross‐talk between macro‐ and microcirculation , 2010, Acta physiologica.

[34]  J. González-Juanatey,et al.  Pravastatin Counteracts Angiotensin II-Induced Upregulation and Activation of NADPH Oxidase at Plasma Membrane of Human Endothelial Cells , 2010, Journal of cardiovascular pharmacology.

[35]  C. Feldstein.  Statins in Hypertension: Are They a New Class of Antihypertensive Agents? , 2008, American journal of therapeutics.

[36]  L. Nežić,et al.  Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation. , 2009, Basic & clinical pharmacology & toxicology.

[37]  Wan Zhang,et al.  Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: a dose-response effect dependent on endothelial nitric oxide synthase. , 2009, International journal of cardiology.

[38]  G. Caimi,et al.  Pathophysiology of polymorphonuclear leukocyte in arterial hypertension. , 2009, Clinical hemorheology and microcirculation.

[39]  B. Lévy,et al.  Effects of Antihypertensive Drugs on Capillary Rarefaction in Spontaneously Hypertensive Rats: Intravital Microscopy and Histologic Analysis , 2008, Journal of cardiovascular pharmacology.

[40]  Y. Katayama,et al.  Effects of long-term administration of HMG-CoA reductase inhibitor, atorvastatin, on stroke events and local cerebral blood flow in stroke-prone spontaneously hypertensive rats , 2007, Brain Research.

[41]  J. Egido,et al.  HMG-CoA Reductase Inhibitors Decrease Angiotensin II–Induced Vascular Fibrosis: Role of RhoA/ROCK and MAPK Pathways , 2007, Hypertension.

[42]  C. Napoli,et al.  Microcirculation and oxidative stress , 2007, Free radical research.

[43]  B. Lévy,et al.  Hypertension: a disease of the microcirculation? , 2006, Hypertension.

[44]  M. Safar,et al.  Increased skin capillary density in treated essential hypertensive patients. , 2006, American journal of hypertension.

[45]  T. Nishioku,et al.  AT1 Receptor Blockade Regulates the Local Angiotensin II System in Cerebral Microvessels From Spontaneously Hypertensive Rats , 2006, Stroke.

[46]  A. Ridley,et al.  Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells. , 2006, Circulation research.

[47]  P. Hordijk.  Regulation of NADPH Oxidases: The Role of Rac Proteins , 2006, Circulation research.

[48]  B. Lévy,et al.  A Disease of the Microcirculation ? , 2006 .

[49]  J. Atkinson,et al.  Constrictor and Dilator Effects of Angiotensin II on Cerebral Arterioles , 2005, Stroke.

[50]  G. Feuerstein,et al.  Simvastatin and losartan enhance nitric oxide and reduce oxidative stress in salt-induced hypertension. , 2005, American journal of hypertension.

[51]  Lie Gao,et al.  Failure : Roles of Angiotensin II Type 1 Receptors and NAD ( P ) H Oxidase Simvastatin Therapy Normalizes Sympathetic Neural Control in Experimental Heart , 2005 .

[52]  E. Ringelstein,et al.  Cerebral small vessel diseases: cerebral microangiopathies , 2005, Current opinion in neurology.

[53]  N. Weintraub,et al.  Antioxidant effects of statins. , 2004, Drugs of today.

[54]  C. Gabay,et al.  Assessment of the efficacy of different statins in murine collagen-induced arthritis. , 2004, Arthritis and rheumatism.

[55]  J. Saavedra,et al.  Angiotensin II AT1 Receptor Blockade Reverses Pathological Hypertrophy and Inflammation in Brain Microvessels of Spontaneously Hypertensive Rats , 2004, Stroke.

[56]  M. Moskowitz,et al.  Laser Speckle Flowmetry for the Study of Cerebrovascular Physiology in Normal and Ischemic Mouse Cortex , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[57]  U. Laufs,et al.  Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment , 2003, Circulation.

[58]  ROSARIO SCALIA,et al.  Microcirculation as a Target for the Anti‐inflammatory Properties of Statins , 2002, Microcirculation.

[59]  N. Hagiwara,et al.  Direct in vivo evidence of a vascular statin: a single dose of cerivastatin rapidly increases vascular endothelial responsiveness in healthy normocholesterolaemic subjects. , 2002, British journal of clinical pharmacology.

[60]  U. Laufs,et al.  Cellular Antioxidant Effects of Atorvastatin In Vitro and In Vivo , 2002, Arteriosclerosis, thrombosis, and vascular biology.

[61]  A. Pries,et al.  Microcirculation in Hypertension: A New Target for Treatment? , 2001, Circulation.

[62]  M. Mulvany,et al.  Vasodilatation, not hypotension, improves resistance vessel design during treatment of essential hypertension: a literature survey , 2001, Journal of hypertension.

[63]  Joerg Kallen,et al.  Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site , 2001, Nature Medicine.

[64]  R. Dietz,et al.  Modulating angiotensin II-induced inflammation by HMG Co-A reductase inhibition. , 2001, American journal of hypertension.

[65]  U. Laufs,et al.  Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. , 2001, Molecular pharmacology.

[66]  Richard E. White,et al.  Angiotensin II Relaxes Microvessels Via the AT2 Receptor and Ca2+-Activated K+ (BKCa) Channels , 2001, Hypertension.

[67]  B. Fautrel,et al.  Affections rhumatismales: G??n??ralit??s , 2000 .

[68]  G. Nickenig,et al.  Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men. , 1999, Circulation.

[69]  J. Chillon,et al.  Effects of an Angiotensin-Converting Enzyme Inhibitor and a β-Blocker on Cerebral Arterioles in Rats , 1999 .

[70]  E. Vicaut.  Microcirculation et hypertension art??rielle , 1999 .

[71]  E. Vicaut.  Microcirculation and arterial hypertension. , 1999, Drugs.

[72]  S. Sela,et al.  Participation of peripheral polymorphonuclear leukocytes in the oxidative stress and inflammation in patients with essential hypertension. , 1997, American journal of hypertension.

[73]  J. Saavedra,et al.  The angiotensin AT1 receptor antagonist CV-11974 regulates cerebral blood flow and brain angiotensin AT1 receptor expression , 1998, Basic Research in Cardiology.

[74]  B H Arison,et al.  In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s. , 1997, Drug metabolism and disposition: the biological fate of chemicals.

[75]  K. Messmer,et al.  Functional capillary density: an indicator of tissue perfusion? , 1995, International journal of microcirculation, clinical and experimental.

[76]  K. Sung,et al.  Properties of circulating leukocytes in spontaneously hypertensive rats. , 1995, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[77]  Peter S. Mortimer,et al.  Capillary rarefaction in the forearm skin in essential hypertension , 1995, Journal of hypertension.

[78]  A. Izzard,et al.  Hypertension and the vasculature: arterioles and the myogenic response , 1995, Journal of hypertension.

[79]  J. Saavedra,et al.  Angiotensin II AT1 receptor mediated contraction of the perfused rat cerebral artery. , 1994, Neuroreport.

[80]  E. Schiffrin,et al.  Effects of a beta-blocker or a converting enzyme inhibitor on resistance arteries in essential hypertension. , 1994, Hypertension.

[81]  W. Meng,et al.  Comparative Effects of Angiotensin‐(1‐7) and Angiotensin II on Piglet Pial Arterioles , 1993, Stroke.

[82]  L. Hansson,et al.  The influence of antihypertensive therapy on the structural arteriolar changes in essential hypertension: different effects of enalapril and hydrochlorothiazide , 1993, Journal of internal medicine.

[83]  V. F. Mauro.  Clinical Pharmacokinetics and Practical Applications of Simvastatin , 1993, Clinical pharmacokinetics.

[84]  J. Saavedra.  Brain and pituitary angiotensin. , 1992, Endocrine reviews.

[85]  F. Delano,et al.  Leukocyte Counts and Activation in Spontaneously Hypertensive and Normotensive Rats , 1991, Hypertension.

[86]  A. Villringer,et al.  Angiotensin II induces endothelium-dependent vasodilation of rat cerebral arterioles. , 1990, The American journal of physiology.

[87]  G. Schmid-Schönbein,et al.  Microvascular tone in a skeletal muscle of spontaneously hypertensive rats. , 1987, Hypertension.

[88]  I I Chen,et al.  Development of microvascular rarefaction in the spontaneously hypertensive rat. , 1982, The American journal of physiology.

[89]  M. Brown,et al.  Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. , 1980, The Journal of clinical investigation.