In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas

Abnormalities in the oxidative metabolism of glucose in human cerebral gliomas have been studied in seven patients using positron emission tomography. Measurements of regional cerebral blood flow and oxygen consumption were obtained using the oxygen‐15 steady‐state inhalation technique. Values of regional cerebral glucose consumption were obtained using fluorine 18–labeled 2‐fluoro‐2‐deoxy‐D‐glucose and a simplification of the method of Sokoloff. Functional values were obtained for regions of tumor and brain tissue in the middle cerebral artery territory of the contralateral cortex. Values of regional glucose consumption were calculated for both regions using a value of the lumped constant quoted for normal brain tissue (0.42).

[1]  Richard S. J. Frackowiak,et al.  Disturbance of oxidative metabolism of glucose in recent human cerebral infarcts , 1983, Annals of neurology.

[2]  J. Shirlaw.  THE METABOLISM OF TUMOURS , 1931 .

[3]  J. Mazziotta,et al.  TOMOGRAPHIC MAPPING OF HUMAN CEREBRAL METABOLISM: NORMAL UNSTIMULATED STATE , 1981 .

[4]  A A Lammertsma,et al.  A Theoretical Study of the Steady‐State Model for Measuring Regional Cerebral Blood Flow and Oxygen Utilisation Using Oxygen‐15 , 1981, Journal of computer assisted tomography.

[5]  T Jones,et al.  Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. , 1981, Brain : a journal of neurology.

[6]  G. Weber.  Enzymology of cancer cells (second of two parts). , 1977, The New England journal of medicine.

[7]  E. Hoffman,et al.  Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method , 1979, Annals of neurology.

[8]  A. Sols,et al.  Substrate specificity of brain hexokinase. , 1954, The Journal of biological chemistry.

[9]  J. Overgaard.  Influence of extracellular pH on the viability and morphology of tumor cells exposed to hyperthermia. , 1976, Journal of the National Cancer Institute.

[10]  M E Phelps,et al.  Validation of tomographic measurement of cerebral blood volume with C-11-labeled carboxyhemoglobin. , 1979, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11]  D Christman,et al.  The radiation dosimetry of 2 [F-18]fluoro-2-deoxy-D-glucose in man. , 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  W. Oldendorf,et al.  Kinetics of Transport and Phosphorylation of 2‐Fluoro‐2‐Deoxy‐d‐Glucose in Rat Brain , 1983, Journal of neurochemistry.

[13]  M. Ter-pogossian,et al.  The continuous inhalation of oxygen-15 for assessing regional oxygen extraction in the brain of man. , 1976, The British journal of radiology.

[14]  J C Mazziotta,et al.  Tomographic mapping of human cerebral metabolism: Sensory deprivation , 1982, Annals of neurology.

[15]  G L Brownell,et al.  Positron imaging in ischemic stroke disease using compounds labeled with oxygen 15. Initial results of clinicophysiologic correlations. , 1981, Archives of neurology.

[16]  D Comar,et al.  Noninvasive tomographic study of cerebral blood flow and oxygen metabolism in vivo. Potentials, limitations, and clinical applications in cerebral ischemic disorders. , 1981, European neurology.

[17]  J. Murphy.  Erythrocyte metabolism. I. The equilibration of glucose-C14 between serum and erythrocytes. , 1960, The Journal of laboratory and clinical medicine.

[18]  W H Oldendorf,et al.  Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. , 1971, The American journal of physiology.

[19]  G. Weber.  Enzymology of cancer cells (first of two parts). , 1977, The New England journal of medicine.

[20]  R A Brooks,et al.  Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography , 1982, Neurology.

[21]  R. Frackowiak,et al.  Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values , 1980, Journal of computer assisted tomography.

[22]  P. Lefevre,et al.  Tracer Exchange vs. Net Uptake of Glucose through Human Red Cell Surface , 1960, The Journal of general physiology.

[23]  A. Gjedde.  Modulation of substrate transport to the brain , 1983, Acta neurologica Scandinavica.

[24]  R. S. J. Frackowiak,et al.  REGIONAL CEREBRAL OXYGEN SUPPLY AND UTILIZATION IN DEMENTIAA CLINICAL AND PHYSIOLOGICAL STUDY WITH OXYGEN-15 AND POSITRON TOMOGRAPHY A CLINICAL AND PHYSIOLOGICAL STUDY WITH OXYGEN - 15 AND POSITRON TOMOHRAPHY , 1981 .

[25]  J. Mazziotta,et al.  Study of Cerebral Function with Positron Computed Tomography , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[26]  B. Siesjö.  A New Journal and a New Society—Why? , 1981 .

[27]  Richard S. J. Frackowiak,et al.  Cerebral Oxygen Metabolism and Blood Flow in Human Cerebral Ischemic Infarction , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[28]  W. Oldendorf,et al.  The Interaction of Transport and Metabolism on Brain Glucose Utilization: A Reevaluation of the Lumped Constant , 1981, Journal of neurochemistry.

[29]  Michael E. Phelps,et al.  Error Sensitivity of Fluorodeoxyglucose Method for Measurement of Cerebral Metabolic Rate of Glucose , 1981 .

[30]  M. Reivich,et al.  THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1 , 1977, Journal of neurochemistry.

[31]  T Jones,et al.  Serial observations on the pathophysiology of acute stroke. The transition from ischaemia to infarction as reflected in regional oxygen extraction. , 1983, Brain : a journal of neurology.

[32]  A A Lammertsma,et al.  A Statistical Study of the Steady State Technique for Measuring Regional Cerebral Blood Flow and Oxygen Utilisation Using 15O , 1982, Journal of computer assisted tomography.

[33]  Michael E. Phelps,et al.  Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [18F] Fluorodeoxyglucose Method , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[34]  H Lund-Andersen,et al.  Transport of glucose from blood to brain. , 1979, Physiological reviews.

[35]  D. F. Heath,et al.  The distribution of glucose and [14C]glucose between erythrocytes and plasma in the rat. , 1969, Biochemical Journal.

[36]  Terry Jones,et al.  Measurement of CBF and CMRO2 using the continuous inhalation of C15O2 and 15O2: Experimental validation using CO2 reactivity in the anaesthetised dog , 1981, Journal of the Neurological Sciences.

[37]  J C Mazziotta,et al.  Quantitation in Positron Emission Computed Tomography: 5. Physical–Anatomical Effects , 1981, Journal of computer assisted tomography.

[38]  E. Hoffman,et al.  Quantitation in Positron Emission Computed Tomography: 1. Effect of Object Size , 1979, Journal of computer assisted tomography.

[39]  David E. Kuhl,et al.  Effect of Ischemia on Quantification of Local Cerebral Glucose Metabolic Rate in Man , 1981, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.