Substance P and capsaicin-induced contraction of human bronchi.

Substance P induced a dose-dependent contraction of human segmental bronchi in vitro with a threshold dose of about 10(-6) M. These preparations were obtained from patients undergoing lung tumor surgery. The substance P-induced contractions were resistant to mepyramine and atropine, suggesting a direct effect on the bronchial smooth muscle. Capsaicin (10(-5) M) also induced a slowly developing strong atropine-resistant contraction of human bronchi in vitro. a rapid tachyphylaxis developed for the response to capsaicin. Both substance P and capsaicin were less potent than acetylcholine and histamine in inducing contractions of human bronchi. This finding may however be partly due to the experimental conditions and both substance P and capsaicin were comparatively much more potent in guinea-pig preparations. Transmural field stimulation of the bronchial preparations in man resulted in contractions that were largely sensitive to atropine. The presence of capsaicin-induced bronchial contractions however indicates the existence of a local non-cholinergic axon-reflex control of bronchial smooth muscle tone by substance P in man.

[1]  T. Hökfelt,et al.  Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. , 1982, Acta physiologica Scandinavica.

[2]  A. Saria,et al.  Capsaicin-sensitive vagal neurons involved in control of vascular permeability in rat trachea. , 1982, Acta physiologica Scandinavica.

[3]  F. Lembeck,et al.  Substance P release from spinal cord slices by capsaicin. , 1979, Life sciences.

[4]  A. Saria,et al.  A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[5]  L. Diamond,et al.  Substance P fails to mimic vagally mediated nonadrenergic bronchodilation , 1982, Peptides.

[6]  T. Hökfelt,et al.  Peptide neurons in the vagus, splanchnic and sciatic nerves. , 1978, Acta physiologica Scandinavica.

[7]  S. Brimijoin,et al.  Axonal transport of substance P in the vagus and sciatic nerves of the guinea pig , 1980, Brain Research.

[8]  J. Beland,et al.  Nonadrenergic inhibitory nervous system in human airways. , 1976, Journal of applied physiology.

[9]  J. Russell,et al.  Reflex bronchoconstriction induced by capsaicin in the dog. , 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

[10]  Y. Matsuzaki,et al.  Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways. , 1980, Science.

[11]  H. Persson,et al.  Effect of substance P on pulmonary resistance and dynamic pulmonary compliance in the anaesthetized cat and guinea-pig. , 2009, Acta pharmacologica et toxicologica.

[12]  T. Hökfelt,et al.  Flare and itch induced by substance P in human skin. , 1978, The Journal of investigative dermatology.

[13]  K. Soltani,et al.  Inhibition of axon reflex vasodilatation by topically applied capsaicin. , 1981, The Journal of investigative dermatology.

[14]  A. C. Cuello,et al.  Capsaicin-induced depletion of substance P from primary sensory neurones , 1978, Brain Research.

[15]  J. Wikberg,et al.  Pharmacological characterization of the autonomous innervation of the guinea pig tracheobronchial smooth muscle. , 2009, Acta pharmacologica et toxicologica.

[16]  J. Polak,et al.  Substance P-like immunoreactive nerves in mammalian lung. , 1979, Investigative & cell pathology.

[17]  R. Coburn,et al.  Evidence for nonadrenergic inhibitory nerves in the guinea pig trachealis muscle. , 1973, The American journal of physiology.

[18]  D. Jacobowitz,et al.  Capsaicin and potassium evoked substance P release from the nucleus tractus solitarius and spinal trigeminal nucleus in vitro. , 1981, Life sciences.

[19]  B. Lynn,et al.  VASCULAR AND SENSORY RESPONSES OF HUMAN SKIN TO MILD INJURY AFTER TOPICAL TREATMENT WITH CAPSAICIN , 1981, British journal of pharmacology.

[20]  J Szolcsányi,et al.  The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. , 1968, British journal of pharmacology and chemotherapy.

[21]  A. Dahlström,et al.  Atropine sensitive contractile motor effects of substance P on the feline pylorus and stomach in vivo. , 1980, Acta physiologica Scandinavica.