Activation of Pax3 target genes is necessary but not sufficient for neurogenesis in the ophthalmic trigeminal placode.

[1]  J. Epstein,et al.  Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. , 2008, Genes & development.

[2]  J. Plotkin,et al.  Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. , 2008, The Journal of clinical investigation.

[3]  M. Bronner‐Fraser,et al.  Essential role for PDGF signaling in ophthalmic trigeminal placode induction , 2008, Development.

[4]  D. Fabbro,et al.  Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities. , 2008, Cancer research.

[5]  C. Baker,et al.  Fine-grained fate maps for the ophthalmic and maxillomandibular trigeminal placodes in the chick embryo. , 2008, Developmental biology.

[6]  S. Ichi,et al.  Key basic helix-loop-helix transcription factor genes Hes1 and Ngn2 are regulated by Pax3 during mouse embryonic development. , 2008, Developmental biology.

[7]  S. Conway,et al.  Lineage-specific responses to reduced embryonic Pax3 expression levels. , 2008, Developmental biology.

[8]  Raman M. Das,et al.  Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion , 2008, Nature Neuroscience.

[9]  M. Buckingham,et al.  The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions. , 2007, Annual review of cell and developmental biology.

[10]  A. Streit The preplacodal region: an ectodermal domain with multipotential progenitors that contribute to sense organs and cranial sensory ganglia. , 2007, The International journal of developmental biology.

[11]  M. Stark,et al.  Canonical Wnt signaling is required for ophthalmic trigeminal placode cell fate determination and maintenance. , 2007, Developmental biology.

[12]  F. Pituello,et al.  The on/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord. , 2007, Developmental biology.

[13]  R. McCole,et al.  A molecular analysis of neurogenic placode and cranial sensory ganglion development in the shark, Scyliorhinus canicula. , 2007, Developmental biology.

[14]  John D West,et al.  Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization , 2006, Development.

[15]  M. Buckingham,et al.  A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb. , 2006, Genes & development.

[16]  G. Schlosser Induction and specification of cranial placodes. , 2006, Developmental biology.

[17]  M. Taketo,et al.  Wnt signals mediate a fate decision between otic placode and epidermis , 2006, Development.

[18]  E. Hoffman,et al.  Fgfr4 Is Required for Effective Muscle Regeneration in Vivo , 2006, Journal of Biological Chemistry.

[19]  A. Cumano,et al.  Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells , 2006, The Journal of cell biology.

[20]  A. Graham,et al.  Vertebrate neurogenin evolution: long-term maintenance of redundant duplicates , 2005, Development Genes and Evolution.

[21]  Sven Hanson,et al.  A balance of FGF, BMP and WNT signalling positions the future placode territory in the head , 2005, Development.

[22]  S. Silver,et al.  New vision from Eyes absent: transcription factors as enzymes. , 2005, Trends in genetics : TIG.

[23]  J. Epstein,et al.  Pax3 functions at a nodal point in melanocyte stem cell differentiation , 2005, Nature.

[24]  A. Streit Early development of the cranial sensory nervous system: from a common field to individual placodes. , 2004, Developmental biology.

[25]  G. Mardon,et al.  Genetic control of retinal specification and determination in Drosophila. , 2004, The International journal of developmental biology.

[26]  G. Schlosser,et al.  Molecular anatomy of placode development in Xenopus laevis. , 2004, Developmental biology.

[27]  C. Marcelle,et al.  In ovo electroporation of avian somites , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[28]  W. Denetclaw,et al.  Precocious terminal differentiation of premigratory limb muscle precursor cells requires positive signalling , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[29]  A. Childs,et al.  Conserved elements in Pax6 intron 7 involved in (auto)regulation and alternative transcription. , 2004, Developmental biology.

[30]  B. Schäfer,et al.  The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo. , 2003, Genes & development.

[31]  E. Turner,et al.  Sonic hedgehog regulates the position of the trigeminal ganglia. , 2003, Developmental biology.

[32]  S. Aota,et al.  Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene. , 2003, Developmental biology.

[33]  J. Epstein,et al.  Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer. , 2003, Human molecular genetics.

[34]  A. Graham,et al.  Early Steps in the Production of Sensory Neurons by the Neurogenic Placodes , 2002, Molecular and Cellular Neuroscience.

[35]  C. Marcelle,et al.  FGFR4 signaling is a necessary step in limb muscle differentiation. , 2002, Development.

[36]  M. Stark,et al.  Pax3-expressing trigeminal placode cells can localize to trunk neural crest sites but are committed to a cutaneous sensory neuron fate. , 2002, Developmental biology.

[37]  A. Streit Extensive cell movements accompany formation of the otic placode. , 2002, Developmental biology.

[38]  David J Anderson,et al.  Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Andrew P McMahon,et al.  A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. , 2002, Development.

[40]  David J. Anderson,et al.  Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. , 2002, Genes & development.

[41]  R. Maas,et al.  Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest. , 2002, Development.

[42]  P. Gruss,et al.  Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites , 2001, Developmental dynamics : an official publication of the American Association of Anatomists.

[43]  H. Nakamura,et al.  Role of Pax3/7 in the tectum regionalization. , 2001, Development.

[44]  P. Gruss,et al.  Pax3 acts cell autonomously in the neural tube and somites by controlling cell surface properties. , 2001, Development.

[45]  I. Skerjanc,et al.  Pax3 Is Essential for Skeletal Myogenesis and the Expression of Six1 and Eya2* , 2001, The Journal of Biological Chemistry.

[46]  M. Collins,et al.  Pax3 and the splotch mutations: structure, function, and relationship to teratogenesis, including gene-chemical interactions. , 2001, Current pharmaceutical design.

[47]  M. Bronner‐Fraser,et al.  Vertebrate cranial placodes I. Embryonic induction. , 2001, Developmental biology.

[48]  B. Druker,et al.  Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome , 2001, Nature Genetics.

[49]  P. Gruss,et al.  Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. , 2000, Genes & development.

[50]  P Gruss,et al.  Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. , 2000, Development.

[51]  A. Groves,et al.  Competence, specification and commitment in otic placode induction. , 2000, Development.

[52]  M. Bronner‐Fraser,et al.  Establishing neuronal identity in vertebrate neurogenic placodes. , 2000, Development.

[53]  P. Gros,et al.  Pax‐3 regulates neurogenesis in neural crest‐derived precursor cells , 1999, Journal of neuroscience research.

[54]  J. Epstein,et al.  Pax3 functions in cell survival and in pax7 regulation. , 1999, Development.

[55]  D. Anderson,et al.  Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo. , 1999, Development.

[56]  K. Lillycrop,et al.  Induction of antisense Pax-3 expression leads to the rapid morphological differentiation of neuronal cells and an altered response to the mitogenic growth factor bFGF. , 1999, Journal of cell science.

[57]  F. Guillemot,et al.  The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons , 1998, Neuron.

[58]  David J. Anderson,et al.  neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia , 1998, Neuron.

[59]  K. Takeda,et al.  Epistatic relationship between Waardenburg Syndrome genes MITF and PAX3 , 1998, Nature Genetics.

[60]  K. Lillycrop,et al.  The DNA binding activity of the paired box transcription factor Pax‐3 is rapidly downregulated during neuronal cell differentiation , 1998, FEBS letters.

[61]  C. Marcelle,et al.  Neural tube-ectoderm interactions are required for trigeminal placode formation. , 1997, Development.

[62]  A. McMahon,et al.  Analysis of neural crest cell migration in Splotch mice using a neural crest-specific LacZ reporter. , 1997, Developmental biology.

[63]  G. Cossu,et al.  Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD , 1997, Cell.

[64]  F. Guillemot,et al.  Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. , 1996, Developmental biology.

[65]  David J. Anderson,et al.  neurogenins,a Novel Family ofatonal-Related bHLH Transcription Factors, Are Putative Mammalian Neuronal Determination Genes That Reveal Progenitor Cell Heterogeneity in the Developing CNS and PNS , 1996, Molecular and Cellular Neuroscience.

[66]  C. MacArthur,et al.  Receptor Specificity of the Fibroblast Growth Factor Family* , 1996, The Journal of Biological Chemistry.

[67]  P. Gruss,et al.  A transgenic neuroanatomical marker identifies cranial neural crest deficiencies associated with the Pax3 mutant Splotch. , 1995, Developmental biology.

[68]  P. Gruss,et al.  Pax3: A paired domain gene as a regulator in PNS myelination , 1995, Neuron.

[69]  G. Edelman,et al.  Pax-3 contains domains for transcription activation and transcription inhibition. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[70]  C. Marcelle,et al.  Distinct developmental expression of a new avian fibroblast growth factor receptor. , 1994, Development.

[71]  K. Vogan,et al.  A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[72]  V. Hamburger,et al.  A series of normal stages in the development of the chick embryo , 1992, Journal of morphology.

[73]  R. J. Mullen,et al.  NeuN, a neuronal specific nuclear protein in vertebrates. , 1992, Development.

[74]  P. Gros,et al.  splotch (Sp2H ), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3 , 1991, Cell.

[75]  D. Stainier,et al.  Pioneer neurons in the mouse trigeminal sensory system. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[76]  D. Covell,et al.  Embryonic development of the chick primary trigeminal sensory‐motor complex , 1989, The Journal of comparative neurology.

[77]  A. Frankfurter,et al.  Development of the peripheral trigeminal system in the chick revealed by an isotype‐specific anti‐beta‐tubulin monoclonal antibody , 1989, The Journal of comparative neurology.

[78]  D. Nichols Mesenchyme formation from the trigeminal placodes of the mouse embryo. , 1986, The American journal of anatomy.

[79]  David J. Anderson,et al.  Molecular probes for the development and plasticity of neural crest derivatives , 1985, Cell.

[80]  D. Noden,et al.  An autoradiographic analysis of the development of the chick trigeminal ganglion. , 1980, Journal of embryology and experimental morphology.

[81]  R. Auerbach Analysis of the developmental effects of a lethal mutation in the house mouse , 1954 .

[82]  J. Epstein,et al.  Getting your Pax straight: Pax proteins in development and disease. , 2002, Trends in genetics : TIG.

[83]  M. Stark,et al.  Competence, specification and induction of Pax-3 in the trigeminal placode. , 1999, Development.

[84]  Verwoerd Cd,et al.  Cephalic neural crest and placodes. , 1979 .

[85]  C. Verwoerd,et al.  Cephalic neural crest and placodes. , 1979, Advances in anatomy, embryology, and cell biology.