Brain Activation During Silent Word Generation Evaluated with Functional MRI

This is a study of word generation during functional MRI (fMRI). Eleven normal healthy subjects were instructed to generate words covertly, (i.e., silently) that began with particular letters. Images were acquired on a conventional 1.5T scanner at three contiguous axial planes encompassing language-related areas of the temporal and frontal lobe. The data were analyzed at the level of a Talairach box, after individually fitting the proportional Talairach grid system to each slice. The main variable of interest was the number of activated pixels within a Talairach box. Boxes with a significant increase in the proportion of activated pixels were located in three regions of the left neocortex: (1) Brodmann areas 44 and 45 in the dorsolateral frontal cortex (Broca's area), (2) areas 21 and 37 in the temporal cortex, (3) and the striate/extrastriate cortex (areas 17 & 18). The results are discussed in terms of a cognitive model of word generation and are compared, in detail, with the results of prior relevant imaging studies.

[1]  K. Faaborg-Andersen,et al.  Electromyography of intrinsic and extrinsic laryngeal muscles during silent speech: correlation with reading activity. , 1958, Acta oto-laryngologica.

[2]  Åke Werner Edfeldt,et al.  Silent speech and silent reading , 1959 .

[3]  Edgar M. Housepian.  Atlas d'anatomie stereotaxique du telencephale. , 1968 .

[4]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[5]  B. J. Winer,et al.  Statistical Principles in Experimental Design, 2nd Edition. , 1973 .

[6]  Steven W. Keele,et al.  Attention and human performance , 1973 .

[7]  E. Perret.  The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour. , 1974, Neuropsychologia.

[8]  Harry A. Whitaker,et al.  Studies in neurolinguistics , 1976 .

[9]  H A Whitaker,et al.  ANATOMIC VARIATIONS IN THE CORTEX: INDIVIDUAL DIFFERENCES AND THE PROBLEM OF THE LOCALIZATION OF LANGUAGE FUNCTIONS , 1976, Annals of the New York Academy of Sciences.

[10]  J. Bogen,et al.  WERNICKE'S REGION–WHERE IS IT? , 1976, Annals of the New York Academy of Sciences.

[11]  N. Geschwind.  Specializations of the human brain. , 1979, Scientific American.

[12]  D. Benson,et al.  Neurologic Correlates of Anomia , 1979 .

[13]  P. Roland,et al.  Supplementary motor area and other cortical areas in organization of voluntary movements in man. , 1980, Journal of neurophysiology.

[14]  D. Wechsler.  WAIS-R manual : Wechsler adult intelligence scale-revised , 1981 .

[15]  A. Marcel.  Conscious and unconscious perception: An approach to the relations between phenomenal experience and perceptual processes , 1983, Cognitive Psychology.

[16]  W. R. Webster,et al.  Uncrossed and crossed inhibition in the inferior colliculus of the cat: a combined 2-deoxyglucose and electrophysiological study , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[17]  M. Mesulam.  Principles of behavioral neurology , 1985 .

[18]  K. Patterson,et al.  Speak and spell: Dissociations and word-class effects. , 1987 .

[19]  M. Coltheart,et al.  The cognitive neuropsychology of language , 1987 .

[20]  M. Buchsbaum,et al.  Cortical glucose metabolic rate correlates of abstract reasoning and attention studied with positron emission tomography , 1988 .

[21]  T. Shallice.  From Neuropsychology to Mental Structure: Converging Operations: Specific Syndromes and Evidence from Normal Subjects , 1988 .

[22]  Carlo Semenza,et al.  Generating proper names: A case of selective inability , 1988 .

[23]  D. Loewenstein,et al.  Cerebral metabolic effects of a verbal fluency test: a PET scan study. , 1988, Journal of clinical and experimental neuropsychology.

[24]  Manuel F. Gonzalez,et al.  Decreases of cortical and thalamic glucose metabolism produced by parietal cortex stimulation in the rat , 1988, Brain Research.

[25]  P. T. Fox,et al.  Positron emission tomographic studies of the cortical anatomy of single-word processing , 1988, Nature.

[26]  A. Damasio,et al.  Lesion analysis in neuropsychology , 1989 .

[27]  K. Lim,et al.  Segmentation of MR Brain Images into Cerebrospinal Fluid Spaces, White and Gray Matter , 1989, Journal of computer assisted tomography.

[28]  C. Semenza,et al.  Evidence from aphasia for the role of proper names as pure referring expressions , 1989, Nature.

[29]  A. Dollins,et al.  Patterns of covert speech behavior and phonetic coding , 1989, The Pavlovian journal of biological science.

[30]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[31]  S. Petersen,et al.  Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli. , 1990, Science.

[32]  Karl J. Friston,et al.  Willed action and the prefrontal cortex in man: a study with PET , 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[33]  Karl J. Friston,et al.  Distribution of cortical neural networks involved in word comprehension and word retrieval. , 1991, Brain : a journal of neurology.

[34]  Karl J. Friston,et al.  A PET study of word finding , 1991, Neuropsychologia.

[35]  Karl J. Friston,et al.  Investigating a network model of word generation with positron emission tomography , 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[36]  M. Raichle,et al.  Localization of a human system for sustained attention by positron emission tomography , 1991, Nature.

[37]  S. Dimauro,et al.  Differential diagnosis of fatal and benign cytochrome c oxidase‐deficient myopathies of infancy , 1991, Neurology.

[38]  F M Miezin,et al.  Activation of the hippocampus in normal humans: a functional anatomical study of memory. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Richard S. J. Frackowiak,et al.  The anatomy of phonological and semantic processing in normal subjects. , 1992, Brain : a journal of neurology.

[40]  H. Buchtel,et al.  Verbal Fluency and Positron Emission Tomographic Mapping of Regional Cerebral Glucose Metabolism , 1992, Cortex.

[41]  Karl J. Friston,et al.  The cortical localization of the lexicons. Positron emission tomography evidence. , 1992, Brain : a journal of neurology.

[42]  Alan C. Evans,et al.  Lateralization of phonetic and pitch discrimination in speech processing. , 1992, Science.

[43]  G. Davis.  A Survey of Adult Aphasia and Related Language Disorders , 1992 .

[44]  C Semenza,et al.  Production of proper names: a clinical case study of the effects of phonemic cueing. , 1993, Memory.

[45]  Alan C. Evans,et al.  Functional activation of the human frontal cortex during the performance of verbal working memory tasks. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[46]  R. Logie,et al.  When working memory does not work. The role of working memory in neuropsychology. , 1993 .

[47]  Karl J. Friston,et al.  Functional mapping of brain areas implicated in auditory--verbal memory function. , 1993, Brain : a journal of neurology.

[48]  L. Friedman,et al.  Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine , 1993, Biological Psychiatry.

[49]  S. Kosslyn,et al.  Visual Mental Imagery Activates Topographically Organized Visual Cortex: PET Investigations , 1993, Journal of Cognitive Neuroscience.

[50]  Richard S. J. Frackowiak,et al.  The neural correlates of the verbal component of working memory , 1993, Nature.

[51]  S. Petersen,et al.  Practice-related changes in human brain functional anatomy during nonmotor learning. , 1994, Cerebral cortex.

[52]  P F Liddle,et al.  The role of the left prefrontal cortex in verbal processing: semantic processing or willed action? , 1994, Neuroreport.

[53]  Andrew Kertesz,et al.  Localization and neuroimaging in neuropsychology , 1994 .

[54]  J. Mazziotta,et al.  Mapping motor representations with positron emission tomography , 1994, Nature.

[55]  D Le Bihan,et al.  Magnetic Resonance Imaging Functional Activation of Left Frontal Cortex During Covert Word Production , 1994, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[56]  M E Raichle,et al.  Visualizing the mind. , 1994, Scientific American.

[57]  P. Goldman-Rakic,et al.  Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46 and relationship to the Talairach Coordinate System. , 1995, Cerebral cortex.

[58]  M. D’Esposito,et al.  The neural basis of the central executive system of working memory , 1995, Nature.

[59]  J. Greene.  Contributions to Neuropsychological Assessment , 1995 .

[60]  Leslie G. Ungerleider,et al.  Age-related reductions in human recognition memory due to impaired encoding. , 1995, Science.

[61]  A Jesmanowicz,et al.  Lateralized human brain language systems demonstrated by task subtraction functional magnetic resonance imaging. , 1995, Archives of neurology.

[62]  M. E. Raichle,et al.  PET Studies of Auditory and Phonological Processing: Effects of Stimulus Characteristics and Task Demands , 1995, Journal of Cognitive Neuroscience.

[63]  S. Petersen,et al.  PET activation of posterior temporal regions during auditory word presentation and verb generation. , 1996, Cerebral cortex.

[64]  J. A. Frost,et al.  Determination of language dominance using functional MRI , 1996, Neurology.

[65]  Stephen M. Rao,et al.  Function of the left planum temporale in auditory and linguistic processing , 1996, NeuroImage.

[66]  L. Katz,et al.  Cerebral organization of component processes in reading. , 1996, Brain : a journal of neurology.

[67]  Edward E. Smith,et al.  Dissociation of Storage and Rehearsal in Verbal Working Memory: Evidence From Positron Emission Tomography , 1996 .

[68]  S E Petersen,et al.  A positron emission tomography study of the short-term maintenance of verbal information , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[69]  Karl J. Friston,et al.  Hearing and saying. The functional neuro-anatomy of auditory word processing. , 1996, Brain : a journal of neurology.

[70]  W. Rosen,et al.  Neuropsychological Assessment, 3rd Edition , 1996 .

[71]  Jonathan S. Lewin,et al.  Functional magnetic resonance imaging in schizophrenia: initial methodology and evaluation of the motor cortex , 1997, Psychiatry Research: Neuroimaging.