Competitive formation of homocircuit [3]rotaxanes in synthetically useful yields in the bipyridine-mediated active template CuAAC reaction

We demonstrate that, depending on reaction conditions, [2]rotaxanes are produced in essentially quantitative yield in the AT-CuAAC reaction regardless of macrocycle size, and hard to access doubly threaded [3]rotaxanes can be synthesised in up to 50% isolated yield in a four component coupling step.

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