Antibacterial Effect of Silver-Incorporated Flake-Shell Nanoparticles under Dual-Modality.

Silver has been recognized as a broad-spectrum antimicrobial agent and extensively used in biomedical applications. Through a sequential one-pot synthesis strategy, we have successfully incorporated silver into flake-shell nanoparticles. Due to the simultaneous growth of networked nanostructures of silica and in situ reduction of silver ions, homogeneously distributed silver into the shell of the nanocapsule was formed. The antibacterial test indicated that the silver-incorporated silica nanocapsule exhibits effective antibacterial activity, inhibiting the bacterial growth by 75%. In addition, with the encapsulation of other antibiotic agent into the structure, an enhanced antibacterial effect under dual-modality could also be achieved.

[1]  J. Barrett,et al.  Antibiotics: where did we go wrong? , 2005, Drug discovery today.

[2]  Bernd Giese,et al.  Nanobio silver: its interactions with peptides and bacteria, and its uses in medicine. , 2013, Chemical reviews.

[3]  M. Ghadiri,et al.  Antibacterial agents based on the cyclic D,L-alpha-peptide architecture. , 2001, Nature.

[4]  N. Hollenberg,et al.  (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[5]  S. Seltzer,et al.  An evaluation of the biocompatibility of a glass ionomer-silver cement in rat connective tissue. , 1989, Journal of endodontics.

[6]  M. Mahmoudi,et al.  Silver-coated engineered magnetic nanoparticles are promising for the success in the fight against antibacterial resistance threat. , 2012, ACS nano.

[7]  Katsuhiko Ariga,et al.  Shell-adjustable hollow ‘soft’ silica spheres as a support for gold nanoparticles , 2013 .

[8]  Jun‐hang Luo,et al.  Mg(II)-Catechin nanoparticles delivering siRNA targeting EIF5A2 inhibit bladder cancer cell growth in vitro and in vivo. , 2016, Biomaterials.

[9]  S. Ghosh,et al.  Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier. , 2011, ACS applied materials & interfaces.

[10]  R. Hurt,et al.  Controlled release of biologically active silver from nanosilver surfaces. , 2010, ACS nano.

[11]  G. Botelho,et al.  Antimicrobial activity of faujasite zeolites doped with silver , 2012 .

[12]  J. Reedijk,et al.  Synthetic models of the active site of catechol oxidase: mechanistic studies. , 2006, Chemical Society reviews.

[13]  Hui Yang,et al.  Metallomics: integrating research related to biometals—a journal for an emerging community , 2009 .

[14]  Helmut Münstedt,et al.  Silver ion release from antimicrobial polyamide/silver composites. , 2005, Biomaterials.

[15]  Katsuhiko Ariga,et al.  Bioactive flake-shell capsules: soft silica nanoparticles for efficient enzyme immobilization. , 2013, Journal of materials chemistry. B.

[16]  Leo H. Koole,et al.  New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles , 2011 .

[17]  Younan Xia,et al.  Silane-based poly(ethylene glycol) as a primer for surface modification of nonhydrolytically synthesized nanoparticles using the Stöber method. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[18]  J. Alexander,et al.  History of the medical use of silver. , 2009, Surgical infections.

[19]  Andreas Fuchs,et al.  Contact-active antimicrobial coatings derived from aqueous suspensions. , 2006, Angewandte Chemie.

[20]  J. Zink,et al.  Antimicrobial Activity of Silver Nanocrystals Encapsulated in Mesoporous Silica Nanoparticles , 2009 .

[21]  E. Skrzypczak‐Jankun,et al.  Why drinking green tea could prevent cancer , 1997, Nature.

[22]  Juan R. Granja,et al.  Antibacterial agents based on the cyclic d,l-α-peptide architecture , 2001, Nature.

[23]  George John,et al.  antimicrobial paints based on vegetable oil , 2008 .

[24]  M. Jennings,et al.  Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance. , 2015, ACS infectious diseases.

[25]  Pedro J J Alvarez,et al.  Negligible particle-specific antibacterial activity of silver nanoparticles. , 2012, Nano letters.

[26]  Amy Milsted,et al.  Silver(I)-imidazole cyclophane gem-diol complexes encapsulated by electrospun tecophilic nanofibers: formation of nanosilver particles and antimicrobial activity. , 2005, Journal of the American Chemical Society.

[27]  K. Ono,et al.  Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases. , 1990, Biochemistry.

[28]  J. Seakins,et al.  Autoxidation of Catechin , 1955, Nature.

[29]  Chunhua Lu,et al.  Two new polyketides from Nocardiopsis lucentensis DSM 44048 , 2016, Natural product research.

[30]  Younan Xia,et al.  Shape‐Controlled Synthesis of Gold and Silver Nanoparticles. , 2003 .

[31]  A D Russell,et al.  Antimicrobial activity and action of silver. , 1994, Progress in medicinal chemistry.

[32]  E. Hoek,et al.  A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment , 2010 .

[33]  J. Abraham,et al.  Comparative analysis of antimicrobial activity of leaf extracts from fresh green tea, commercial green tea and black tea on pathogens , 2011 .

[34]  M. Saleem,et al.  Antimicrobial Natural Products: An Update on Future Antibiotic Drug Candidates , 2010 .

[35]  Katsuhiko Ariga,et al.  Bioinspired nanoarchitectonics as emerging drug delivery systems , 2014 .

[36]  M. M. Cowan.  Plant Products as Antimicrobial Agents , 1999, Clinical Microbiology Reviews.

[37]  P. Messersmith,et al.  Antibacterial performance of polydopamine-modified polymer surfaces containing passive and active components. , 2011, ACS applied materials & interfaces.

[38]  Yuan Gao,et al.  Recent Advances in Antimicrobial Treatments of Textiles , 2008 .

[39]  Michael V. Liga,et al.  Antimicrobial nanomaterials for water disinfection and microbial control: potential applications and implications. , 2008, Water research.

[40]  Eladia María Peña-Méndez,et al.  Silver or silver nanoparticles: a hazardous threat to the environment and human health? , 2008 .

[41]  S. Sánchez‐Cortés,et al.  Spectroscopic and pulse radiolysis studies of the antioxidant properties of (+)catechin: metal chelation and oxidizing radical scavenging , 2008 .

[42]  M. Rai,et al.  Silver nanoparticles as a new generation of antimicrobials. , 2009, Biotechnology advances.

[43]  Pierre Picouet,et al.  Metallic-based micro and nanocomposites in food contact materials and active food packaging , 2012 .

[44]  Pier Paolo Pompa,et al.  Nanosilver-based antibacterial drugs and devices: mechanisms, methodological drawbacks, and guidelines. , 2014, Chemical Society reviews.

[45]  D. Zhao,et al.  Core-shell Ag@SiO2@mSiO2 mesoporous nanocarriers for metal-enhanced fluorescence. , 2011, Chemical communications.

[46]  Katsuhiko Ariga,et al.  Flake-shell capsules: adjustable inorganic structures. , 2012, Small.

[47]  Jun Yang,et al.  Synthesis of Ag–TiO2 composite nano thin film for antimicrobial application , 2011, Nanotechnology.

[48]  Apurba K. Das,et al.  Smart oligopeptide gels: in situ formation and stabilization of gold and silver nanoparticles within supramolecular organogel networks. , 2006, Chemical communications.

[49]  Dae Hong Jeong,et al.  Antimicrobial effects of silver nanoparticles. , 2007, Nanomedicine : nanotechnology, biology, and medicine.

[50]  Quansheng Chen,et al.  Enhancing the antimicrobial activity of natural extraction using the synthetic ultrasmall metal nanoparticles , 2015, Scientific Reports.

[51]  Hui Yang,et al.  Mesoporous silica microcapsule-supported Ag nanoparticles fabricated via nano-assembly and its antibacterial properties , 2012 .

[52]  Joe J. Harrison,et al.  Antimicrobial activity of metals: mechanisms, molecular targets and applications , 2013, Nature Reviews Microbiology.

[53]  Morteza Mahmoudi,et al.  Antibacterial properties of nanoparticles. , 2012, Trends in biotechnology.

[54]  Katsuhiko Ariga,et al.  Manipulation of shell morphology of silicate spheres from structural evolution in a purely inorganic system. , 2015, Chemistry, an Asian journal.

[55]  Ke Karlovu,et al.  The bactericidal effect of silver nanoparticles , 2010 .

[56]  Ayusman Sen,et al.  Silver bromide nanoparticle/polymer composites: dual action tunable antimicrobial materials. , 2006, Journal of the American Chemical Society.

[57]  Katsuhiko Ariga,et al.  Natural tubule clay template synthesis of silver nanorods for antibacterial composite coating. , 2011, ACS applied materials & interfaces.

[58]  Lakshmi P Kotra,et al.  Design of novel antibiotics that bind to the ribosomal acyltransfer site. , 2002, Journal of the American Chemical Society.

[59]  Younan Xia,et al.  Synthesis of silver nanostructures with controlled shapes and properties. , 2007, Accounts of chemical research.

[60]  M. Hande,et al.  Cytotoxicity and genotoxicity of silver nanoparticles in human cells. , 2009, ACS nano.

[61]  Rong Xu,et al.  Silver Nanoparticles Deposited Layered Double Hydroxide Nanoporous Coatings with Excellent Antimicrobial Activities , 2012 .

[62]  Matthias Epple,et al.  Silver as antibacterial agent: ion, nanoparticle, and metal. , 2013, Angewandte Chemie.