WCK 4873 (INN: Nafithromycin): Structure-Activity relationship (SAR) identifying a novel lactone ketolide with activity against Streptococcus pneumoniae (SPN) and Streptococcus pyogenes (SPY)
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S. Pawar | S. Bhagwat | T. Ravikumar | A. K. Kayastha | R. Yeole | M. Nandanwar | Sunil Gupta | P. Deshpande | M. Patel | S. Dabhade | S. Bhavsar
[1] Structural Diversification of 14-Membered Macrolides , 2022, Synfacts.
[2] M. Gdaniec,et al. An Approach to Modify 14-Membered Lactone Macrolide Antibiotic Scaffolds , 2022, The Journal of organic chemistry.
[3] K. Rangappa,et al. A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies. , 2021, European journal of medicinal chemistry.
[4] R. Chavan,et al. Preclinical Safety Evaluation of Nafithromycin (WCK 4873) with emphasis on liver safety in Rat and Dog. , 2021, Regulatory toxicology and pharmacology : RTP.
[5] F. Bartl,et al. Synthesis and antibacterial activity of new N-alkylammonium and carbonate-triazole derivatives within desosamine of 14- and 15-membered lactone macrolides. , 2020, ChemMedChem.
[6] D. Gowda,et al. Multi-targeted quinazolinone-Schiff's bases as potent bio-therapeutics , 2020 .
[7] A. Janas,et al. 14- and 15-membered lactone macrolides and their analogues and hybrids: structure, molecular mechanism of action and biological activity. , 2019, European journal of medicinal chemistry.
[8] P. Iwanowski,et al. Safety, Tolerability, and Pharmacokinetics of Oral Nafithromycin (WCK 4873) after Single or Multiple Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects , 2019, Antimicrobial Agents and Chemotherapy.
[9] H. K. Vivek,et al. Aryl fluorosulfate analogues as potent antimicrobial agents: SAR, cytotoxicity and docking studies. , 2018, Bioorganic chemistry.
[10] P. Lei,et al. Synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains. , 2018, Bioorganic & medicinal chemistry letters.
[11] Hua-Li Qin,et al. Master mechanisms of Staphylococcus aureus: consider its excellent protective mechanisms hindering vaccine development! , 2018, Microbiological research.
[12] Shivakumar,et al. Effect of Low Charge and High Hydrophobicity on Antimicrobial Activity of the Quinazolinone-Peptide Conjugates , 2018, Russian Journal of Bioorganic Chemistry.
[13] G. Dinos. The macrolide antibiotic renaissance , 2017, British journal of pharmacology.
[14] J. Karlowsky,et al. Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia , 2016, Drugs.
[15] Krystian Pyta,et al. Regio- and Stereoselective Functionalization of 16-Membered Lactone Aglycone of Spiramycin via Cascade Strategy. , 2015, The Journal of organic chemistry.
[16] M. Cushman,et al. Synthesis, antibacterial activity and docking of 14-membered 9-O-(3-arylalkyl) oxime 11,12-cyclic carbonate ketolides. , 2013, European journal of medicinal chemistry.
[17] Krystian Pyta,et al. Transformation of josamycin in alkaline solution—intramolecular SN2 substitution or E1cB elimination and intramolecular Michael addition? , 2011 .
[18] P. Przybylski. Modifications and Biological Activity of Natural and Semisynthetic 16-Membered Macrolide Antibiotics , 2011 .
[19] William M. Lee,et al. Telithromycin‐associated hepatotoxicity: Clinical spectrum and causality assessment of 42 cases , 2009, Hepatology.
[20] T. Kaneko,et al. Novel tethers in ketolide antibiotics. , 2007, Bioorganic & medicinal chemistry letters.
[21] S. Lociuro,et al. A novel ketolide class: Synthesis and antibacterial activity of a lead compound. , 2007, Bioorganic & medicinal chemistry letters.
[22] W. Mcmillen,et al. Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. , 2007, Bioorganic & medicinal chemistry letters.
[23] K. Bush,et al. Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives. , 2007, Bioorganic & medicinal chemistry letters.
[24] L. Kellenberger,et al. Antipropionibacterial Activity of BAL19403, a Novel Macrolide Antibiotic , 2007, Antimicrobial Agents and Chemotherapy.
[25] T. Iwaki,et al. A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: synthesis and structure-activity relationships. , 2006, Bioorganic & Medicinal Chemistry.
[26] T. Iwaki,et al. A new type of ketolides bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether synthesis and structure-activity relationships. , 2005, Bioorganic & medicinal chemistry.
[27] T. Yasukata,et al. 9-Oxime-3-ketolides: modification at the C-11,12-diol moiety and antibacterial activities against key respiratory pathogens. , 2005, Bioorganic & medicinal chemistry.
[28] N. Soni,et al. Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae. , 2005, Bioorganic & Medicinal Chemistry Letters.
[29] Stuart Hayden,et al. The synthesis of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their ketolides , 2005 .
[30] M. Jacobs,et al. Activities of Two Novel Macrolides, GW 773546 and GW 708408, Compared with Those of Telithromycin, Erythromycin, Azithromycin, and Clarithromycin against Haemophilus influenzae , 2004, Antimicrobial Agents and Chemotherapy.
[31] I. Akritopoulou‐Zanze,et al. Synthesis and antibacterial activity of novel bifunctional macrolides. , 2004, Bioorganic & medicinal chemistry letters.
[32] L. Kellenberger,et al. Novel ketolide antibiotics with a fused five-membered lactone ring--synthesis, physicochemical and antimicrobial properties. , 2004, Bioorganic & medicinal chemistry.
[33] M. Mitten,et al. Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. , 2004, Bioorganic & medicinal chemistry letters.
[34] G. Stone,et al. Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. , 2003, Journal of medicinal chemistry.
[35] Suoming Zhang,et al. Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. , 2001, Journal of medicinal chemistry.
[36] T. Dougherty,et al. ABT-773: a new ketolide antibiotic , 2001, Expert opinion on investigational drugs.
[37] A. Bryskier. Ketolides-telithromycin, an example of a new class of antibacterial agents. , 2000, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
[38] M. Mitten,et al. Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens. , 2000, Journal of medicinal chemistry.