Organization and regulation of mitogen-activated protein kinase signaling pathways.

[1]  C. Widmann,et al.  Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. , 1999, Physiological reviews.

[2]  G. Johnson,et al.  The TAO of MEKK. , 1998, Frontiers in bioscience : a journal and virtual library.

[3]  Paul W Sternberg,et al.  Conspiracy Theory RAS and RAF Do Not Act Alone , 1998, Cell.

[4]  G. Rubin,et al.  CNK, a RAF-Binding Multidomain Protein Required for RAS Signaling , 1998, Cell.

[5]  C. Venot,et al.  Grb2 Interaction with MEK-Kinase 1 Is Involved in Regulation of Jun-Kinase Activities in Response to Epidermal Growth Factor* , 1998, The Journal of Biological Chemistry.

[6]  E. Elion.  Routing MAP Kinase Cascades , 1998, Science.

[7]  H. Schaeffer,et al.  MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. , 1998, Science.

[8]  Min Han,et al.  SUR-8, a Conserved Ras-Binding Protein with Leucine-Rich Repeats, Positively Regulates Ras-Mediated Signaling in C. elegans , 1998, Cell.

[9]  Joseph Avruch,et al.  A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity , 1998, Nature.

[10]  J. Engelman,et al.  Caveolin‐mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo , 1998, FEBS letters.

[11]  C. Widmann,et al.  MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis , 1998, Molecular and Cellular Biology.

[12]  E. Elion,et al.  Functional binding between Gβ and the LIM domain of Ste5 is required to activate the MEKK Ste11 , 1998, Current Biology.

[13]  C. Widmann,et al.  14-3-3 Proteins Interact with Specific MEK Kinases* , 1998, The Journal of Biological Chemistry.

[14]  G. Waeber,et al.  IB1, a JIP-1-related Nuclear Protein Present in Insulin-secreting Cells* , 1998, The Journal of Biological Chemistry.

[15]  J. Gutkind.  The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades* , 1998, The Journal of Biological Chemistry.

[16]  P. Thuriaux,et al.  τ91, an Essential Subunit of Yeast Transcription Factor IIIC, Cooperates with τ138 in DNA Binding , 1998, Molecular and Cellular Biology.

[17]  H. Schaeffer,et al.  A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation , 1998 .

[18]  C. Venot,et al.  Grb 2 Interaction with MEK-Kinase 1 Is Involved in Regulation of Jun-Kinase Activities in Response to Epidermal Growth Factor * , 1998 .

[19]  W. Fantl,et al.  Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK , 1998, Current Biology.

[20]  M. Yaffe,et al.  The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity , 1997, Cell.

[21]  M. Cobb,et al.  MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases* , 1997, The Journal of Biological Chemistry.

[22]  T. Pawson,et al.  Signaling through scaffold, anchoring, and adaptor proteins. , 1997, Science.

[23]  M. Lisanti,et al.  Interaction of a Receptor Tyrosine Kinase, EGF-R, with Caveolins , 1997, The Journal of Biological Chemistry.

[24]  J. Thorner,et al.  Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. , 1997, Science.

[25]  T. Tan,et al.  Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[26]  C. Der,et al.  14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain* , 1997, The Journal of Biological Chemistry.

[27]  G. Johnson,et al.  MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42 , 1997, The EMBO journal.

[28]  M E Greenberg,et al.  A cytoplasmic inhibitor of the JNK signal transduction pathway. , 1997, Science.

[29]  G. Salvesen,et al.  The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases , 1997, Cell.

[30]  Emiko Suzuki,et al.  A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade , 1997, Nature.

[31]  G. Fink,et al.  14-3-3 Proteins Are Essential for RAS/MAPK Cascade Signaling during Pseudohyphal Development in S. cerevisiae , 1997, Cell.

[32]  F. Posas,et al.  Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. , 1997, Science.

[33]  D. Morrison,et al.  The complexity of Raf-1 regulation. , 1997, Current opinion in cell biology.

[34]  Jiahuai Han,et al.  NIK is a new Ste20‐related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain , 1997, The EMBO journal.

[35]  C. Widmann,et al.  MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases? , 1997, Current opinion in genetics & development.

[36]  A. Levitzki,et al.  Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[37]  M. C. Hu,et al.  Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. , 1996, Genes & development.

[38]  J. Scott,et al.  More on target with protein phosphorylation: conferring specificity by location. , 1996, Trends in biochemical sciences.

[39]  A. Newton.  Protein kinase C: Ports of anchor in the cell , 1996, Current Biology.

[40]  M. Karin,et al.  Mitogen-activated protein kinase cascades and regulation of gene expression. , 1996, Current opinion in immunology.

[41]  John D. Scott,et al.  Molecular Glue: Kinase Anchoring and Scaffold Proteins , 1996, Cell.

[42]  P. Allen,et al.  Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine , 1996, Cell.

[43]  H. Horvitz,et al.  The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans , 1995, Cell.

[44]  Min Han,et al.  The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction , 1995, Cell.

[45]  Henry C. Chang,et al.  KSR, a novel protein kinase required for RAS signal transduction , 1995, Cell.

[46]  M. Whiteway,et al.  Molecular Characterization of Ste20p, a Potential Mitogen-activated Protein or Extracellular Signal-regulated Kinase Kinase (MEK) Kinase Kinase from Saccharomyces cerevisiae(*) , 1995, The Journal of Biological Chemistry.

[47]  D. Morrison,et al.  Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases. , 1995, Science.

[48]  G. Johnson,et al.  Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1) (*) , 1995, The Journal of Biological Chemistry.

[49]  D. Mochly‐Rosen.  Localization of protein kinases by anchoring proteins: a theme in signal transduction. , 1995, Science.

[50]  Tony Pawson,et al.  Protein modules and signalling networks , 1995, Nature.

[51]  W. Kolch,et al.  Regulation of Raf‐1 kinase activity by the 14‐3‐3 family of proteins. , 1995, The EMBO journal.

[52]  I. Herskowitz.  MAP kinase pathways in yeast: For mating and more , 1995, Cell.

[53]  Rubin Cs.  A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. , 1994 .

[54]  L. Zon,et al.  Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 , 1994, Nature.

[55]  G. Sprague,,et al.  Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. , 1994, Genetics.

[56]  K. Xia,et al.  Interaction of the protein kinase Raf-1 with 14-3-3 proteins. , 1994, Science.

[57]  K. Irie,et al.  Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. , 1994, Science.

[58]  F. McCormick,et al.  Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. , 1994, Science.

[59]  E. Elion,et al.  Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae , 1994, Cell.

[60]  M. Wigler,et al.  Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. , 1994, Proceedings of the National Academy of Sciences of the United States of America.