Hormonal regulation of human adipocytes at the cross-roads between obesity and hypertension.

In this issue of the journal, Gorzelniak et al. [1] examined the expression of the genes coding for the components of the renin–angiotensin system (RAS) in the subcutaneous abdominal adipocytes of 30 women, of whom 18 were obese and 10 had hypertension in combination with obesity. Compared with 12 lean women, the expression of the angiotensinogen (AGT) gene was significantly lower in the adipocytes from the 18 obese subjects. Furthermore, the renin, angiotensin II-converting enzyme and angiotensin II type-1 receptor (ATR1) genes were up-regulated in the adipocytes of 10 obese hypertensive women. Thus, Gorzelniak et al. [1] demonstrated that the RAS genes are differently expressed in adipocytes of obese and hypertensive women. Using an innovative approach, these investigators completed their clinical study with in-vitro experiments. They observed that hydrocortisone increased ATR1 gene expression in human adipocytes in a timeand dose-dependent manner, whereas hydrocortisone did not influence the expression of the other RAS genes. Furthermore, insulin, 17â-oestradiol, triiodo-Lthyronine and angiotensin II did not influence any of the RAS genes in the in-vitro experiments. The work of Gorzelniak et al. [1] is an important contribution to the existing literature, but should also be interpreted within the context of certain limitations. Although the sample size was larger than in many other reports, the Berlin group only recruited women. Furthermore, differences in age and menstrual cycle may have impacted on the findings and the study did not include lean hypertensive women.

[1]  Arya M. Sharma,et al.  Hormonal regulation of the human adipose-tissue renin–angiotensin system: relationship to obesity and hypertension , 2002, Journal of hypertension.

[2]  A. Shuldiner,et al.  Resistin, obesity, and insulin resistance--the emerging role of the adipocyte as an endocrine organ. , 2001, The New England journal of medicine.

[3]  P. Schling,et al.  Effects of Angiotensin II on Adipose Conversion and Expression of Genes of the Renin-Angiotensin System in Human Preadipocytes , 2001, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[4]  G. Giacchetti,et al.  Gene expression of angiotensinogen in adipose tissue of obese patients , 2000, International Journal of Obesity.

[5]  P. Arner,et al.  Increased adipose angiotensinogen gene expression in human obesity. , 2000, Obesity research.

[6]  M. Schambelan,et al.  The tissue renin‐angiotensin system in rats with fructose‐ induced hypertension: overexpression of type 1 angiotensin II receptor in adipose tissue , 2000, Journal of hypertension.

[7]  S. Reynisdottir,et al.  The association of human adipose angiotensinogen gene expression with abdominal fat distribution in obesity , 2000, International Journal of Obesity.

[8]  T. Rice,et al.  Body fat, resting and exercise blood pressure and the angiotensinogen M235T polymorphism: the heritage family study. , 1999, Obesity research.

[9]  Y. Toya,et al.  Angiotensinogen gene polymorphism near transcription start site and blood pressure: role of a T-to-C transition at intron I. , 1999, Hypertension.

[10]  P. Schling,et al.  Evidence for a local renin angiotensin system in primary cultured human preadipocytes , 1999, International Journal of Obesity.

[11]  R A Shaffer,et al.  Obesity-induced hypertension : New concepts from the emerging biology of obesity , 1999 .

[12]  A Kumar,et al.  Role of C/A polymorphism at -20 on the expression of human angiotensinogen gene. , 1999, Hypertension.

[13]  L. Sjöström,et al.  Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. , 1998, The Journal of clinical endocrinology and metabolism.

[14]  G. Frühbeck,et al.  Leptin: physiology and pathophysiology. , 1998, Clinical physiology.

[15]  C. Craven,et al.  Human spiral artery renin-angiotensin system. , 1998, Hypertension.

[16]  G. Ailhaud,et al.  Insulin down-regulates angiotensinogen gene expression and angiotensinogen secretion in cultured adipose cells. , 1998, Biochemical and biophysical research communications.

[17]  N. Cook,et al.  Angiotensinogen genotype, sodium reduction, weight loss, and prevention of hypertension: trials of hypertension prevention, phase II. , 1998, Hypertension.

[18]  C. Darimont,et al.  Regulation by glucocorticoids of angiotensinogen gene expression and secretion in adipose cells. , 1997, The Biochemical journal.

[19]  S. Umemura,et al.  Essential hypertension and 5' upstream core promoter region of human angiotensinogen gene. , 1997, Hypertension.

[20]  J. W. Taylor,et al.  Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control. , 1997, The American journal of physiology.

[21]  J. Lalouel,et al.  Haplotypes of angiotensinogen in essential hypertension. , 1997, American journal of human genetics.

[22]  B. H. Jones,et al.  Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells. , 1997, Endocrinology.

[23]  John Quackenbush,et al.  A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. , 1997, The Journal of clinical investigation.

[24]  N. Kalsheker,et al.  Angiotensinogen: molecular biology, biochemistry and physiology. , 1996, The international journal of biochemistry & cell biology.

[25]  R. Hegele,et al.  Genetic variation on chromosome 1 associated with variation in body fat distribution in men. , 1995, Circulation.

[26]  P. Game,et al.  The expression and localisation of the angiotensin-converting enzyme mRNA in human adipose tissue. , 1994, Blood pressure.

[27]  M. Phillips,et al.  Levels of angiotensin and molecular biology of the tissue renin angiotensin systems , 1993, Regulatory Peptides.

[28]  Steven C. Hunt,et al.  Molecular basis of human hypertension: Role of angiotensinogen , 1992, Cell.

[29]  M. Zamboni,et al.  Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships. , 1992, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[30]  T. Unger,et al.  Tissue renin-angiotensin systems in the heart and vasculature: possible involvement in the cardiovascular actions of converting enzyme inhibitors. , 1990, The American journal of cardiology.

[31]  L. Wei,et al.  Regulation of angiotensinogen gene. , 1989, American journal of hypertension.

[32]  Vicotor J Dzau,et al.  Circulating versus local renin‐angiotensin system in cardiovascular homeostasis , 1988, Circulation.

[33]  M E Safar,et al.  Large conduit arteries in hypertension: role of the vascular renin-angiotensin system. , 1988, Circulation.

[34]  V. Dzau Implications of local angiotensin production in cardiovascular physiology and pharmacology. , 1987, The American journal of cardiology.

[35]  P R Biondetti,et al.  Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography. , 1986, The American journal of clinical nutrition.

[36]  J. Staessen,et al.  Blood pressure and urinary cations in urban Bantu of Zaire. , 1986, American journal of epidemiology.

[37]  C. Bulpitt,et al.  Four urinary cations and blood pressure. A population study in two Belgian towns. , 1983, American journal of epidemiology.