Challenges in Implementing High-Density Formats for High Throughput Screening

Developments in human genomics and combinatorial chemistry will create a rapid increase in the number of targets and number of compounds to be screened against those targets. This, combined with increasing cost-con tainment in drug discovery, will create a need within high throughput screening (HIS) groups to increase the efficiency of the screening process . One response to this need is the move to high density formats (HDP's). Use of an HDF will increase screening efficiency in terms of