EDITORIAL 983 From child to adult: Putting the patient first and foremost M. Couffon, E. Stoneham and P. J. Turner 985 The complexity of drug hypersensitivity reactions M. J. Torres GUIDELINE 988 EAACI Biologicals Guidelines—dupilumab for children and adults with moderate-to-severe atopic dermatitis I. Agache, C. Akdis, M. Akdis, K. Brockow, T. Chivato, S. del Giacco, T. Eiwegger, K. Eyerich, A. Giménez-Arnau, J. Gutermuth, E. Guttman-Yassky, M. Maurer, G. Ogg, P. Y. Ong, L. O’Mahony, J. Schwarze, A. Warner, T. Werfel, O. Palomares and M. Jutel 1010 Noninvasive and minimally invasive techniques for the diagnosis and management of allergic diseases R. Baumann, E. Untersmayr, U. M. Zissler, S. Eyerich, I. M. Adcock, K. Brockow, T. Biedermann, M. Ollert, A. M. Chaker, O. Pfaar, H. Garn, R. S. Thwaites, A. Togias, M. L. Kowalski, T. T. Hansel, C. A. Jakwerth and C. B. Schmidt-Weber REVIEW ARTICLES 1024 The evolution of IgE-mediated type I hypersensitivity and its immunological value D. I. Pritchard, F. H. Falcone and P. D. Mitchell 1041 Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model C. Incorvaia, M. Al-Ahmad, I. J. Ansotegui, S. Arasi, C. Bachert, C. Bos, J. Bousquet, A. Bozek, D. Caimmi, M. A. Calderón, T. Casale, A. Custovic, F. De Blay, P. Demoly, P. Devillier, A. Didier, A. Fiocchi, A. T. Fox, P. Gevaert, M. Gomez, E. Heffler, N. Ilina, C. Irani, M. Jutel, E. Karagiannis, L. Klimek, P. Kuna, R. O'Hehir, O. Kurbacheva, P. M. Matricardi, M. Morais-Almeida, R. Mosges, N. Novak, Y. Okamoto, P. Panzner, N. G. Papadopoulos, H.-S. Park, G. Passalacqua, R. Pawankar, O. Pfaar, P. Schmid-Grendelmeier, S. Scurati, M. Tortajada-Girbés, C. Vidal, J. C. Virchow, U. Wahn, M. Worm, P. Zieglmayer and G. W. Canonica 1053 Systemic treatments in the management of atopic dermatitis: A systematic review and meta-analysis D. Siegels, A. Heratizadeh, S. Abraham, J. Binnmyr, K. Brockow, A. D. Irvine, S. Halken, C. G. Mortz, C. Flohr, P. Schmid-Grendelmeier, L.-A. Van der Poel, A. Muraro, S. Weidinger, T. Werfel and J. Schmitt 1077 Cold urticaria – What we know and what we do not know N. Maltseva, E. Borzova, D. Fomina, M. Bizjak, D. Terhorst-Molawi, M. Košnik, K. Kulthanan, R. Meshkova, S. F. Thomsen and M. Maurer