The exceptional electro-optic properties of poled polymer films, coupled with the power and flexibility of thin film fabrication and photolithographic processing, may make possible a new class of integrated optic systems: photonic large scale integration (PLSI). PLSI systems are characterized by the hybrid integration of electronic and photonic devices, combining the processing power of VLSI with a dense, high bandwidth, photonic interconnection and switching network in a single, large format, package. In this paper, we describe the potential applications and benefits of PLSI and present a review of some of the relevant progress to date in electro-optic polymer materials and devices, including the demonstration of polymer switch based 100 Mbit/sec digital signal transmission for optical interconnection and a 20 GHz electro-optic polymer modulator.