Allogeneic H‐2 does not Cross‐react, at the Helper T‐Cell Level, with Hapten‐modified Self

Helper T cell raised in CBA mice and enriched in vitro with specificity for trinitrophenylmodified syngeneic spleen cells can activate hapten‐modified B cells bearing Ik. These helper cells fail to activate B cells expressing any of six independent I‐region haplotypes, indicating lack of cross‐reactivity between hapten‐self and allogeneic I‐region products, Furthermore, hapten‐derivatized allogeneic B sells are also not activated, demonstrating that the elements restricting T‐cell function are poorly, if at all, cross‐reactive.

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