The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.

Aucun gene HLA seul n'a ete identifie comme conferant un risque de maladie. Distinction et definition des sous-types DR4. Role de la 3eme region hypervariable de DRβ1. Relation entre risque de pemphigus et DW1eme et DRW6eme, et relation entre susceptibilite a la polyarthrite rhumatoide et un groupe d'epitopes trouves dans les sous-types non DW10 de DR4

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