Design, synthesis, anti-inflammatory, analgesic screening, and molecular docking of some novel 2-pyridyl (3H)-quinazolin-4-one derivatives

[1]  M. Perrone,et al.  Selective COX-1 inhibition: A therapeutic target to be reconsidered. , 2010, Current medicinal chemistry.

[2]  T. Yakaiah,et al.  Synthesis of novel 4,6-disubstituted quinazoline derivatives, their anti-inflammatory and anti-cancer activity (cytotoxic) against U937 leukemia cell lines. , 2008, European journal of medicinal chemistry.

[3]  Claudio N. Cavasotto,et al.  Protein flexibility in ligand docking and virtual screening to protein kinases. , 2004, Journal of molecular biology.

[4]  R. Kroemer Molecular modelling probes: docking and scoring. , 2003, Biochemical Society transactions.

[5]  R. Kovács,et al.  A glutamate receptor subtype antagonist inhibits seizures in rat hippocampal slices , 2002, NeuroReport.

[6]  J. A. Rodríguez-Feo,et al.  Reduction of the soluble cyclic GMP vasorelaxing system in the vascular wall of stroke-prone spontaneously hypertensive rats: effect of the α1-receptor blocker doxazosin , 2002, Journal of hypertension.

[7]  N. Altorki,et al.  Inhibition of Cyclooxygenase‐2 , 2001, Annals of the New York Academy of Sciences.

[8]  A. Bekhit,et al.  Synthesis and antimicrobial evaluation of chalcone and syndrome derivatives of 4(3H)-quinazolinone. , 2001, Bollettino chimico farmaceutico.

[9]  A. Caruso,et al.  Synthesis and pharmacological study of ethyl 1-methyl-5-(substituted 3,4-dihydro-4-oxoquinazolin-3-yl)-1H-pyrazole-4-acetates. , 2001, European journal of medicinal chemistry.

[10]  J. van Ryn,et al.  COX-2 selectivity and inflammatory processes. , 2000, Current medicinal chemistry.

[11]  G. Scriba,et al.  Synthesis and Anticonvulsant Activity of Acetylenic Quinazolinone Derivatives , 2000, Archiv der Pharmazie.

[12]  J. Carter,et al.  Inhibitors of cyclooxygenase-2: November 1999 - April 2000 , 2000 .

[13]  J. Macor,et al.  N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction. , 2000, Journal of medicinal chemistry.

[14]  A. Moharram,et al.  Synthesis and in vitro antifungal activity of some N,N-disubstituted dithiocarbamic acid esters derived from 2-methylquinazolinones. , 1999, Bollettino chimico farmaceutico.

[15]  D. Schillaci,et al.  Synthesis of new 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol-5-yl)-amino] substituted 4(3H)-quinazolinone derivatives with antineoplastic activity. , 1999, Die Pharmazie.

[16]  S. Akuzawa,et al.  Comparative study of [3H]ramosetron and [3H]granisetron binding in the cloned human 5-hydroxytryptamine3 receptors. , 1998, Japanese journal of pharmacology.

[17]  L. Ceraulo,et al.  Studies in organic mass spectrometry. IV: Electron impact induced fragmentation of 2-substituted 3-(5-isoxazolyl)-4(3H)-quinazolinones of pharmaceutical interest , 1984 .

[18]  M. Yamamura,et al.  [Effects of afloqualone, a new centrally acting muscle relaxant, on DRL response and CER in rats (author's transl)]. , 1981, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[19]  P. Singh STUDY IN NITROGEN MUSTARDS. PART II. SYNTHESIS OF SOME 2-ALKYL-3-ARYL-4(3H)-QUINAZOLINONE DERIVATIVES AS POSSIBLE ANTITUMOR AGENTS , 1979 .

[20]  Y. Tamura,et al.  Studies in organic mass spectrometry—II , 1971 .

[21]  C A WINTER,et al.  Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs , 1962, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[22]  R. Enriz,et al.  SYNTHESIS AND PRELIMINARY CYTOTOXIC AND ANTIFUNGAL EVALUATION OF SOME 6-N,N-DIALKYL 2-ARYL-4(3H)-QUINAZOLINONE DERIVATIVES , 2001 .

[23]  V. Ram,et al.  Chemotherapeutic agents. XIX. Synthesis of [1,2,4]‐Triazoloquinazolinones and related compounds as antihypertensive agents , 1990 .

[24]  R. Ishida,et al.  Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. , 1982, Japanese journal of pharmacology.

[25]  R. Ishida,et al.  PHARMACOLOGICAL STUDIES ON 6-AMINO-2-FLUOROMETHYL-3-(O-TOLYL)-4(3H)-QUINAZOLINONE (AFLOQUALONE), A NEW CENTRALLY ACTING MUSCLE RELAXANT (I) , 1981 .

[26]  Y. Yamada,et al.  Studies on biologically active halogenated compounds. 1. Synthesis and central nervous system depressant activity of 2-(fluoromethyl)-3-aryl-4(3H)-quinazolinone derivatives. , 1979, Journal of medicinal chemistry.

[27]  R. Koster,et al.  ACETIC ACID FOR ANALGESIC SCREENING , 1959 .