Cutaneous lymphadenoma: an adnexal neoplasm with intralobular activated lymphoid cells.

Cutaneous lymphadenoma is an uncommon epithelial neoplasm with a controverted adnexal differentiation. We report a typical case of cutaneous lymphadenoma that developed on the left cheek of a 18-year-old woman. Histologically, the neoplasm consisted of lobules of basaloid cells with a peripheral palisading array and filled with a lymphocyte-predmoninant mixed cellular population. Numerous intralobular cells with ample amphopilic cytoplasm, large vesicular nuclei, and prominent nucleoli also were noticed. Immunohistochemical study showed labeling of these Reed-Sternberg-like large cells by antibodies against CD30 antigen. Our findings suggest that cutaneous lymphadenoma is a poorly differentiated adnexal neoplasm, probably trichoblastoma-related, where a singular interaction with several immune cells is established, including activated large lymphocytes analogous to those malignantly proliferating in Hodgkin's disease.

[1]  R. Betti,et al.  Nodular trichoblastoma with adamantinoid features. , 1996, The American Journal of dermatopathology.

[2]  C. Díaz‐Cascajo,et al.  Cutaneous lymphadenoma. A peculiar variant of nodular trichoblastoma. , 1996, The American Journal of dermatopathology.

[3]  H. Kerl,et al.  Primary Cutaneous Hodgkin's Disease. Unique Clinical, Morphologic, and Immunophenotypic Findings , 1994, The American Journal of dermatopathology.

[4]  C. Tomasini,et al.  Cutaneous lymphadenoma. A basal cell carcinoma with unusual inflammatory reaction pattern? , 1993, The American Journal of dermatopathology.

[5]  R. M. Mackie,et al.  Cutaneous lymphadenoma: a case report and review of the literature , 1993, The British journal of dermatology.

[6]  L. Requena,et al.  Cutaneous lymphadenoma with ductal differentiation , 1992, Journal of cutaneous pathology.

[7]  E. Zafrani,et al.  Cutaneous lymphadenoma with focal mucinosis , 1992, Journal of cutaneous pathology.

[8]  I. Masouyé.  Cutaneous lymphadenoma: report of 2 cases. , 1992, Dermatology.

[9]  W. Tsang,et al.  So‐called cutaneous lymphadenoma: a lymphotropic solid syringoma? , 1991, Histopathology.

[10]  S. Pileri,et al.  Variable expression of leucocyte-common (CD45) antigen in CD30 (Ki1)-positive anaplastic large-cell lymphoma: implications for the differential diagnosis between lymphoid and nonlymphoid malignancies. , 1990, Human Pathology.

[11]  A. Chott,et al.  Ki‐1‐Positive Large Cell Lymphoma: A Clinicopathologic Study of 41 Cases , 1990, The American journal of surgical pathology.

[12]  E. Marinho,et al.  [Epithelio-lymphohistiocytic tumor. Apropos of 3 cases]. , 1990, Annales de dermatologie et de venereologie.

[13]  S. Pileri,et al.  BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. , 1989, Blood.

[14]  B. Nickoloff,et al.  Role of interferon-gamma in cutaneous trafficking of lymphocytes with emphasis on molecular and cellular adhesion events. , 1988, Archives of dermatology.

[15]  S. Pileri,et al.  Expression of lymphoid‐associated antigens on Hodgkin's and Reed‐Sternberg cells of Hodgkin's disease. An immunocytochemical study on lymph node cytospins using monoclonal antibodies , 1987, Histopathology.

[16]  Paul J. Kurtin,et al.  Epithelial membrane antigen--a diagnostic discriminant in surgical pathology: immunohistochemical profile in epithelial, mesenchymal, and hematopoietic neoplasms using paraffin sections and monoclonal antibodies. , 1985, Human pathology.

[17]  H. Stein,et al.  HUMAN LYMPHOID CELLS EXPRESS EPITHELIAL MEMBRANE ANTIGEN Implications for Diagnosis of Human Neoplasms , 1984, The Lancet.

[18]  V. Diehl,et al.  Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells , 1982, Nature.