Biochemical and rheological analysis of human colonic culture mucus reveals similarity to gut mucus

[1]  Thomas C. Ferrante,et al.  Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology , 2019, bioRxiv.

[2]  G. Radicioni,et al.  Endotracheal Tube Mucus as a Source of Airway Mucus for Rheological Study. , 2019, American journal of physiology. Lung cellular and molecular physiology.

[3]  N. Allbritton,et al.  Building a Thick Mucus Hydrogel Layer to Improve the Physiological Relevance of In Vitro Primary Colonic Epithelial Models , 2019, Cellular and molecular gastroenterology and hepatology.

[4]  P. Petrini,et al.  Towards bioinspired in vitro models of intestinal mucus , 2019, RSC advances.

[5]  M. Wolfgang,et al.  Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis , 2019, Science Translational Medicine.

[6]  B. Schroeder.  Fight them or feed them: how the intestinal mucus layer manages the gut microbiota , 2019, Gastroenterology report.

[7]  R. Tarran,et al.  Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH , 2018, European Respiratory Journal.

[8]  N. Allbritton,et al.  Analysis of Interleukin 8 Secretion by a Stem-Cell-Derived Human-Intestinal-Epithelial-Monolayer Platform. , 2018, Analytical chemistry.

[9]  Raehyun Kim,et al.  Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer , 2017, Cellular and molecular gastroenterology and hepatology.

[10]  S. Edwardson,et al.  Transition from fractional to classical Stokes–Einstein behaviour in simple fluids , 2017, Royal Society Open Science.

[11]  V. Théodorou,et al.  Mucus organisation is shaped by colonic content; a new view , 2017, Scientific Reports.

[12]  K. Takeda,et al.  Roles of intestinal epithelial cells in the maintenance of gut homeostasis , 2017, Experimental &Molecular Medicine.

[13]  Angela Proctor,et al.  Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells , 2017, Cellular and molecular gastroenterology and hepatology.

[14]  J. M. Murray,et al.  Predicting first traversal times for virions and nanoparticles in mucus with slowed diffusion. , 2015, Biophysical journal.

[15]  S. Hazen,et al.  Oxidation increases mucin polymer cross-links to stiffen airway mucus gels , 2015, Science Translational Medicine.

[16]  Scott A. McKinley,et al.  Micro-heterogeneity metrics for diffusion in soft matter. , 2014, Soft matter.

[17]  Scott A. McKinley,et al.  A Biophysical Basis for Mucus Solids Concentration as a Candidate Biomarker for Airways Disease , 2014, PloS one.

[18]  H. Clevers.  The Intestinal Crypt, A Prototype Stem Cell Compartment , 2013, Cell.

[19]  M. Johansson,et al.  The gastrointestinal mucus system in health and disease , 2013, Nature Reviews Gastroenterology &Hepatology.

[20]  D. Hill,et al.  A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia , 2012, Science.

[21]  M. Johansson,et al.  Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins , 2012, PloS one.

[22]  B. Johansson,et al.  Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin , 2012, Proceedings of the National Academy of Sciences.

[23]  D. Hill,et al.  Establishment of respiratory air-liquid interface cultures and their use in studying mucin production, secretion, and function. , 2012, Methods in molecular biology.

[24]  S. Sarin,et al.  Hydrogels formed through regulated self-organization of gradually charging chitosan in solution of xanthan , 2010 .

[25]  Gunnar C. Hansson,et al.  The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions , 2010, Proceedings of the National Academy of Sciences.

[26]  R. Hodges,et al.  Conjunctival Goblet Cells , 2010 .

[27]  S. Young,et al.  Macrorheology of cystic fibrosis, chronic obstructive pulmonary disease & normal sputum , 2009, Respiratory research.

[28]  Denis Wirtz,et al.  Micro- and macrorheology of mucus. , 2009, Advanced drug delivery reviews.

[29]  N. Alexis,et al.  Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways? , 2008, American journal of physiology. Lung cellular and molecular physiology.

[30]  S. Gendler,et al.  Structure and function of the cell surface (tethered) mucins. , 2008, Annual review of physiology.

[31]  T. Waigh,et al.  Molecular structure and rheological properties of short-side-chain heavily glycosylated porcine stomach mucin. , 2007, Biomacromolecules.

[32]  B. Celli,et al.  Exacerbations of chronic obstructive pulmonary disease , 2007, European Respiratory Journal.

[33]  A. Allen,et al.  Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. , 2005, American journal of physiology. Cell physiology.

[34]  L. Thim,et al.  Effect of trefoil factors on the viscoelastic properties of mucus gels , 2002, European journal of clinical investigation.

[35]  E. Greenberg,et al.  A component of innate immunity prevents bacterial biofilm development , 2002, Nature.

[36]  L. Holm,et al.  The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[37]  Thomas G. Mason,et al.  Estimating the viscoelastic moduli of complex fluids using the generalized Stokes–Einstein equation , 2000 .

[38]  Y. Kim,et al.  Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. , 1994, The Journal of biological chemistry.

[39]  M. Copin,et al.  Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. , 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[40]  J. Widdicombe,et al.  The effect of vasoactive intestinal peptide on smooth muscle tone and mucus secretion from the ferret trachea , 1987, British journal of pharmacology.

[41]  P. Allison,et al.  The Oesophagus Lined with Gastric Mucous Membrane , 1953, Thorax.