Dramatic neuromuscular paralysis following occult snakebites: An awareness for the primary care physician

Neurotoxic snakebites are a common emergency in tropical countries and account for significant morbidity and mortality worldwide. Manifestations vary from mild ptosis and ophthalmoplegia to severe flaccid paralysis with ventilatory failure. At times, the neuromuscular paralysis may be severe enough for patients to be misdiagnosed as a locked-in syndrome or brain dead. Occult snakebites, wherein patients are unaware of the bite and fang marks are absent, have been reported in kraits, an endemic neurotoxic snake belonging to the Elapidae family. We report a series of three cases in which young males presented with dramatic neuromuscular paralysis and were likely suffering from elapid snake bites. Each of these patients presented an intriguing clinical challenge and had different in-hospital outcomes. Primary care physicians in the emergency department are usually the first respondents to such patients. Owing to a lack of snake bite history and unavailability of specific diagnostic tests, severe envenomation presents a challenge for physicians, unless they are aware of it and a high level of suspicion is maintained.

[1]  A. Gupta,et al.  Unusually prolonged neuromuscular weakness caused by krait (Bungarus caeruleus) bite: Two case reports. , 2021, Toxicon : official journal of the International Society on Toxinology.

[2]  Mohammad Saffree Jeffree,et al.  Determinants of snakebite mortality in Asia: A systematic review , 2021, Annals of medicine and surgery.

[3]  E. Gnedovskaya,et al.  Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project. , 2020, JAMA.

[4]  Saeed A. Alqahtani,et al.  Cobra snakebite mimicking brain death treated with a novel combination of polyvalent snake antivenom and anticholinesterase: Case report. , 2020, The American journal of emergency medicine.

[5]  P. Jha,et al.  Trends in snakebite deaths in India from 2000 to 2019 in a nationally representative mortality study , 2020, eLife.

[6]  Sushant Khanduri,et al.  Brain Dead Presentation of Snake Bite , 2018, Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine.

[7]  Dhruvkumar M. Patel,et al.  A rare case of common krait envenomation presented with locked-in syndrome masquerading as brain death , 2018 .

[8]  V. Chauhan Early morning neuroparalysis is diagnostic of Krait bite. , 2017, Journal of forensic and legal medicine.

[9]  M. Sharma,et al.  An eleven year old boy with pain abdomen and early morning neuroparalytic syndrome. , 2016, Journal of forensic and legal medicine.

[10]  V. Mahajan,et al.  Locked-in syndrome as a presentation of snakebite , 2013, Indian Pediatrics.

[11]  S. Mehta,et al.  Clinical Features And Management Of Snake Bite. , 2002, Medical journal, Armed Forces India.

[12]  S. Kularatne Common krait (Bungarus caeruleus) bite in Anuradhapura, Sri Lanka: a prospective clinical study, 1996–98 , 2002, Postgraduate medical journal.