Fluorescence mapping of transmembrane potentials during cardiac stimulation

An important effect of electrical stimulation on myocardial tissue is the change in the transmembrane voltage induced during the stimulation pulse. This initial effect then activates transmembrane voltage-dependent ion channels and can produce a propagated action potential after the pulse. Fluorescence mapping with transmembrane voltage-sensitive dye has been used to measure the direction of the initial change in transmembrane voltage-sensitive during a stimulation pulse and the magnitude of the change relative to the action potential amplitude.

[1]  N. Sperelakis,et al.  A new method for preparation of isolated single adult myocytes. , 1984, The American journal of physiology.

[2]  R E Ideker,et al.  Optical measurements of transmembrane potential changes during electric field stimulation of ventricular cells. , 1993, Circulation research.

[3]  R. Ideker,et al.  Effect of Intrastimulus Polarity Reversal on Electric Field Stimulation Thresholds in Frog and Rabbit Myocardium , 1992 .

[4]  W. M. Smith,et al.  Effect of field stimulation on cellular repolarization in rabbit myocardium. Implications for reentry induction. , 1992, Circulation research.

[5]  Y Afework,et al.  Dispersion of Repolarization Induced by a Nonuniform Shock Field , 1991, Pacing and clinical electrophysiology : PACE.

[6]  B. C. Hill,et al.  Optical Recordings of the Effect of Electrical Stimulation on Action Potential Repolarization and the Induction of Reentry in Two‐Dimensional Perfused Rabbit Epicardium , 1993, Circulation.

[7]  P D Wolf,et al.  Cardiac Potential and Potential Gradient Fields Generated by Single, Combined, and Sequential Shocks During Ventricular Defibrillation , 1992, Circulation.

[8]  R W GERARD,et al.  The normal membrane potential of frog sartorius fibers. , 1949, Journal of cellular and comparative physiology.

[9]  J. Jones,et al.  Conditioning prepulse of biphasic defibrillator waveforms enhances refractoriness to fibrillation wavefronts. , 1991, Circulation research.

[10]  S. Weidmann.  Electrical constants of trabecular muscle from mammalian heart , 1970, The Journal of physiology.

[11]  N. G. Sepulveda,et al.  Current injection into a two-dimensional anisotropic bidomain. , 1989, Biophysical journal.

[12]  S M Dillon,et al.  Optical recordings in the rabbit heart show that defibrillation strength shocks prolong the duration of depolarization and the refractory period. , 1991, Circulation research.