Targeting accuracy of an image guided gating system for stereotactic body radiotherapy

Recently, a commercial system capable of x-ray image guided patient positioning and respiratory gated delivery has become available. Here we describe the operational principles of this system and investigate its geometric targeting accuracy under controlled conditions. The system tracks breathing via infrared (IR) detection of reflective markers located on the patient's abdomen. Localization kilovoltage (kV) x-rays are triggered from within the gated delivery window portion of the breathing trace and after positioning, the tumour will cross the linac isocentre during gated delivery. We tested geometric accuracy of this system by localizing and delivering gated fields to a moving phantom. Effects of phantom speed, gating window location, timing errors and phantom rotations on positioning and gating accuracy were investigated. The system delivered gated fields to both a moving and static phantom with equal accuracy. The position of the gating window affects accuracy only to the extent that an asymmetric breathing motion could affect dose distribution within its boundaries. Positioning errors were found to be less then 0.5 +/- 0.2 mm for phantom rotations up to 5 degrees. We found and corrected a synchronization error caused by a faulty x-ray duration setting and detected a 60 +/- 20 ms time delay in our linear accelerator.

[1]  P. Keall,et al.  WE-C-J-6C-02: Investigation of Variables Affecting Residual Motion for Respiratory Gated Radiotherapy , 2005 .

[2]  Hiroki Shirato,et al.  Feasibility of synchronization of real-time tumor-tracking radiotherapy and intensity-modulated radiotherapy from viewpoint of excessive dose from fluoroscopy. , 2004, International journal of radiation oncology, biology, physics.

[3]  G J Kutcher,et al.  Deep inspiration breath-hold technique for lung tumors: the potential value of target immobilization and reduced lung density in dose escalation. , 1999, International journal of radiation oncology, biology, physics.

[4]  C. Ling,et al.  Results of a phase I dose‐escalation study using three‐dimensional conformal radiotherapy in the treatment of inoperable nonsmall cell lung carcinoma , 2005, Cancer.

[5]  A. Giatromanolaki,et al.  Radiotherapy alone for non-small cell lung carcinoma. Five-year disease-free survival and patterns of failure. , 1995, Acta oncologica.

[6]  C. Ramsey,et al.  Clinical efficacy of respiratory gated conformal radiation therapy. , 1999, Medical dosimetry : official journal of the American Association of Medical Dosimetrists.

[7]  Koichi Yamazaki,et al.  Feasibility of insertion/implantation of 2.0-mm-diameter gold internal fiducial markers for precise setup and real-time tumor tracking in radiotherapy. , 2003, International journal of radiation oncology, biology, physics.

[8]  Gikas S. Mageras,et al.  Fluoroscopic evaluation of diaphragmatic motion reduction with a respiratory gated radiotherapy system , 2001, Journal of applied clinical medical physics.

[9]  Radhe Mohan,et al.  Feasibility of sparing lung and other thoracic structures with intensity-modulated radiotherapy for non-small-cell lung cancer. , 2004, International journal of radiation oncology, biology, physics.

[10]  Koichi Yamazaki,et al.  Real‐time tumor‐tracking radiation therapy for lung carcinoma by the aid of insertion of a gold marker using bronchofiberscopy , 2002, Cancer.

[11]  Radhe Mohan,et al.  Patient training in respiratory-gated radiotherapy. , 2003, Medical dosimetry : official journal of the American Association of Medical Dosimetrists.

[12]  Fang-Fang Yin,et al.  Time delay measurement for linac based treatment delivery in synchronized respiratory gating radiotherapy. , 2005, Medical physics.

[13]  C. Ling,et al.  Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer. , 2000, International journal of radiation oncology, biology, physics.

[14]  C. Ling,et al.  Improved local control with higher doses of radiation in large-volume stage III non-small-cell lung cancer. , 2004, International journal of radiation oncology, biology, physics.

[15]  Steve B Jiang,et al.  Synchronized moving aperture radiation therapy (SMART): average tumour trajectory for lung patients. , 2003, Physics in medicine and biology.

[16]  Radhe Mohan,et al.  Four-dimensional radiotherapy planning for DMLC-based respiratory motion tracking. , 2005, Medical physics.

[17]  Timothy D. Solberg,et al.  Infrared patient positioning for stereotactic radiosurgery of extracranial tumors , 1999, Comput. Biol. Medicine.

[18]  Kai-Liang Wu,et al.  Three-dimensional conformal radiation therapy for non-small-cell lung cancer: a phase I/II dose escalation clinical trial. , 2003, International journal of radiation oncology, biology, physics.

[19]  R. Mohan,et al.  Quantifying the predictability of diaphragm motion during respiration with a noninvasive external marker. , 2003, Medical physics.

[20]  K. Ohara,et al.  Irradiation synchronized with respiration gate. , 1989, International journal of radiation oncology, biology, physics.

[21]  J. Wong,et al.  The use of active breathing control (ABC) to reduce margin for breathing motion. , 1999, International journal of radiation oncology, biology, physics.

[22]  H. Shirato,et al.  Four-dimensional treatment planning and fluoroscopic real-time tumor tracking radiotherapy for moving tumor. , 2000, International journal of radiation oncology, biology, physics.

[23]  S. Taylor,et al.  Combined modality therapy for stage III non-small cell lung carcinoma: results of treatment and patterns of failure. , 1992, International journal of radiation oncology, biology, physics.

[24]  P Pemler,et al.  Influence of respiration-induced organ motion on dose distributions in treatments using enhanced dynamic wedges. , 2001, Medical physics.

[25]  E. Larsen,et al.  A method for incorporating organ motion due to breathing into 3D dose calculations. , 1999, Medical physics.

[26]  Martin J Murphy,et al.  Issues in respiratory motion compensation during external-beam radiotherapy. , 2002, International journal of radiation oncology, biology, physics.

[27]  Quynh-Thu Le,et al.  Stereotactic radiosurgery for lung tumors: preliminary report of a phase I trial. , 2003, The Annals of thoracic surgery.

[28]  Suresh Senan,et al.  Procedures for high precision setup verification and correction of lung cancer patients using CT-simulation and digitally reconstructed radiographs (DRR). , 2003, International journal of radiation oncology, biology, physics.

[29]  M van Herk,et al.  Quantification of organ motion during conformal radiotherapy of the prostate by three dimensional image registration. , 1995, International journal of radiation oncology, biology, physics.

[30]  Steve B. Jiang,et al.  Residual motion of lung tumours in gated radiotherapy with external respiratory surrogates , 2005, Physics in medicine and biology.

[31]  Hui Yan,et al.  A phantom study on the positioning accuracy of the Novalis Body system. , 2003, Medical physics.

[32]  H Shirato,et al.  Detection of lung tumor movement in real-time tumor-tracking radiotherapy. , 2001, International journal of radiation oncology, biology, physics.

[33]  T. Bortfeld,et al.  How much margin reduction is possible through gating or breath hold? , 2005, Physics in medicine and biology.

[34]  Hans-Peter Meinzer,et al.  Influence of different breathing maneuvers on internal and external organ motion: use of fiducial markers in dynamic MRI. , 2005, International journal of radiation oncology, biology, physics.

[35]  George Starkschall,et al.  Evaluation of internal lung motion for respiratory-gated radiotherapy using MRI: Part II-margin reduction of internal target volume. , 2004, International journal of radiation oncology, biology, physics.

[36]  Koichi Yamazaki,et al.  Insertion and fixation of fiducial markers for setup and tracking of lung tumors in radiotherapy. , 2005, International journal of radiation oncology, biology, physics.

[37]  Jean-Philippe Pignol,et al.  Correlation of lung tumor motion with external surrogate indicators of respiration. , 2004, International journal of radiation oncology, biology, physics.

[38]  M. Brundage,et al.  Involved-field radiotherapy alone for early-stage non-small-cell lung cancer. , 2000, International journal of radiation oncology, biology, physics.

[39]  C. Ling,et al.  Evaluation of respiratory movement during gated radiotherapy using film and electronic portal imaging. , 2002, International journal of radiation oncology, biology, physics.

[40]  Thomas Guerrero,et al.  Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer. , 2004, International journal of radiation oncology, biology, physics.

[41]  B. Jeremic,et al.  Radiotherapy alone in technically operable, medically inoperable, early-stage (I/II) non-small-cell lung cancer. , 2002, International journal of radiation oncology, biology, physics.

[42]  George Starkschall,et al.  Evaluation of internal lung motion for respiratory-gated radiotherapy using MRI: Part I--correlating internal lung motion with skin fiducial motion. , 2004, International journal of radiation oncology, biology, physics.

[43]  Gikas S. Mageras,et al.  Interfractional anatomic variation in patients treated with respiration‐gated radiotherapy , 2005, Journal of applied clinical medical physics.

[44]  D A Jaffray,et al.  The effects of intra-fraction organ motion on the delivery of dynamic intensity modulation. , 1998, Physics in medicine and biology.

[45]  M. V. van Herk,et al.  Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. , 2002, International journal of radiation oncology, biology, physics.

[46]  E. Yorke,et al.  Respiratory gating for liver tumors: Use in dose escalation , 2003 .

[47]  S Minohara,et al.  Respiratory gated irradiation system for heavy-ion radiotherapy. , 2000, International journal of radiation oncology, biology, physics.

[48]  J. Adler,et al.  Robotic Motion Compensation for Respiratory Movement during Radiosurgery , 2000, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[49]  Suresh Senan,et al.  Benefit of respiration-gated stereotactic radiotherapy for stage I lung cancer: an analysis of 4DCT datasets. , 2005, International journal of radiation oncology, biology, physics.

[50]  Y. Tsunashima,et al.  Correlation between the respiratory waveform measured using a respiratory sensor and 3D tumor motion in gated radiotherapy. , 2004, International journal of radiation oncology, biology, physics.

[51]  R. Emery,et al.  Clinical experience using respiratory gated radiation therapy: comparison of free-breathing and breath-hold techniques. , 2004, International journal of radiation oncology, biology, physics.

[52]  H. Kubo,et al.  Respiration gated radiotherapy treatment: a technical study. , 1996, Physics in medicine and biology.

[53]  Uwe Oelfke,et al.  Compensation for respiratory motion by gated radiotherapy: an experimental study , 2005, Physics in medicine and biology.

[54]  Achim Schweikard,et al.  Respiration tracking in radiosurgery. , 2004, Medical physics.

[55]  R. Mohan,et al.  Motion adaptive x-ray therapy: a feasibility study , 2001, Physics in medicine and biology.

[56]  Kevin Cleary,et al.  A robotic 3-D motion simulator for enhanced accuracy in CyberKnife stereotactic radiosurgery , 2004, CARS.

[57]  J Debus,et al.  Influence of intra-fractional breathing movement in step-and-shoot IMRT. , 2004, Physics in medicine and biology.

[58]  C C Ling,et al.  The deep inspiration breath-hold technique in the treatment of inoperable non-small-cell lung cancer. , 2000, International journal of radiation oncology, biology, physics.

[59]  Nzhde Agazaryan,et al.  An evaluation of gating window size, delivery method, and composite field dosimetry of respiratory-gated IMRT. , 2002, Medical physics.

[60]  R K Ten Haken,et al.  Dose escalation in non-small-cell lung cancer using three-dimensional conformal radiation therapy: update of a phase I trial. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[61]  Y Suh,et al.  A feasibility study on the prediction of tumour location in the lung from skin motion. , 2004, The British journal of radiology.

[62]  K. Lam,et al.  Improvement of CT-based treatment-planning models of abdominal targets using static exhale imaging. , 1998, International journal of radiation oncology, biology, physics.

[63]  M. V. van Herk,et al.  Physical aspects of a real-time tumor-tracking system for gated radiotherapy. , 2000, International journal of radiation oncology, biology, physics.

[64]  H. Shirato,et al.  Integration of fluoroscopic real-time tumor-tracking system and tomographic scanner on the rail in the treatment room , 2004 .

[65]  Shinichi Shimizu,et al.  Real-time tumour-tracking radiotherapy , 1999, The Lancet.

[66]  Y. Ung,et al.  Reproducibility of lung tumor position and reduction of lung mass within the planning target volume using active breathing control (ABC). , 2003, International journal of radiation oncology, biology, physics.