Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL
暂无分享,去创建一个
M. Kaplan | G. Sandusky | G. Marcucci | A. Cardoso | A. Kloetgen | I. Aifantis | N. Carlesso | M. Chiang | M. Wunderlich | J. Mulloy | F. Boccalatte | M. Yui | A. Zollman | R. Bonfim-Silva | Christina Abundis | Huajia Zhang | Lin Wang | Sonia Rodriguez | J. Palmer | P. Mehrotra
[1] J. Barata,et al. IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update , 2019, Advances in biological regulation.
[2] R. Mohammad,et al. Dysregulated expression of SKP2 and its role in hematological malignancies , 2018, Leukemia & lymphoma.
[3] K. Blackwell,et al. HR+, HER2– Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles , 2017, Current cancer drug targets.
[4] F. Locatelli,et al. The combination of bortezomib with chemotherapy to treat relapsed/refractory acute lymphoblastic leukaemia of childhood , 2017, British journal of haematology.
[5] A. Ferrando,et al. The genetics and mechanisms of T cell acute lymphoblastic leukaemia , 2016, Nature Reviews Cancer.
[6] Ellen V. Rothenberg,et al. Developmental gene networks: a triathlon on the course to T cell identity , 2014, Nature Reviews Immunology.
[7] D. Chen,et al. Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner. , 2014, Cell stem cell.
[8] Emma R. Andersson,et al. Therapeutic modulation of Notch signalling — are we there yet? , 2014, Nature Reviews Drug Discovery.
[9] Jon C. Aster,et al. NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers , 2013, Proceedings of the National Academy of Sciences.
[10] M. Hung,et al. Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression , 2013, Cell.
[11] C. Pui,et al. Relapsed childhood acute lymphoblastic leukaemia. , 2013, The Lancet. Oncology.
[12] J. Aster,et al. Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells. , 2013, Blood.
[13] M. Pagano,et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. , 2012, Chemistry & biology.
[14] J. Hazle,et al. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis , 2012, Cell.
[15] J. Soulier,et al. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. , 2012, Cancer cell.
[16] Jung-Hyun Park,et al. Intrathymic IL-7: the where, when, and why of IL-7 signaling during T cell development. , 2012, Seminars in immunology.
[17] J. Hazle,et al. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis , 2012, Cell.
[18] K. Nakayama,et al. The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs. , 2011, Blood.
[19] J. Aster,et al. Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies , 2011, The Journal of pathology.
[20] A. Ferrando,et al. T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993). , 2009, Blood.
[21] A. Ferrando,et al. CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia , 2009, The Journal of experimental medicine.
[22] Susan M. Schlenner,et al. Faculty Opinions recommendation of CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia. , 2009 .
[23] D. Koller,et al. The Immunological Genome Project: networks of gene expression in immune cells , 2008, Nature Immunology.
[24] J. Aster,et al. Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. , 2008, The Journal of clinical investigation.
[25] K. Nakayama,et al. Absence of Skp2 Expression Attenuates Bcr-abl-induced , 2008 .
[26] M. Pagano,et al. Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer , 2008, Nature Reviews Cancer.
[27] D. Hershko,et al. Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer , 2008, Cancer.
[28] A. Cardoso,et al. Notch pathway is regulated by leukemia microenvironmental cues and positively modulates IL-7 signaling , 2007 .
[29] U. Lendahl,et al. Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines. , 2007, Experimental cell research.
[30] L. Appleman,et al. CD28 Costimulation Mediates Transcription of SKP2 and CKS1, the Substrate Recognition Components of SCFSkp2 Ubiquitin Ligase That Leads p27kip1 to Degradation , 2006, Cell cycle.
[31] J. Aster,et al. Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1 , 2006, Molecular and Cellular Biology.
[32] P. Kaldis,et al. IL-7 promotes T cell proliferation through destabilization of p27Kip1 , 2006, The Journal of experimental medicine.
[33] W. Gordon,et al. Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation , 2005, The Journal of experimental medicine.
[34] Andrew P. Weng,et al. Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia , 2004, Science.
[35] A. Ferrando,et al. IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. , 2004, Blood.
[36] A. Ferrando,et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. , 2003, Cancer cell.
[37] W. Pear,et al. Notch and the immune system. , 2003, Immunity.
[38] K. Nakayama,et al. Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[39] M. Pagano,et al. Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase* , 2003, Journal of Biological Chemistry.
[40] S. Reed,et al. The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). , 2002, Genes & development.
[41] J. Aster,et al. Notch signaling in hematopoiesis and early lymphocyte development , 2002, Immunological reviews.
[42] J. Barata,et al. Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1). , 2001, Blood.
[43] M. Pagano,et al. Role of the F-box protein Skp2 in lymphomagenesis , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[44] M. Kitagawa,et al. Down-Regulation of p27Kip1 Expression Is Required for Development and Function of T Cells1 , 2001, The Journal of Immunology.
[45] M. Kaplan,et al. Cytokine-Stimulated T Lymphocyte Proliferation Is Regulated by p27Kip1 1 , 2000, The Journal of Immunology.
[46] M. Kitagawa,et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication , 2000, The EMBO journal.
[47] Michele Pagano,et al. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 , 1999, Nature Cell Biology.
[48] J. Sklar,et al. Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics , 1999 .
[49] J. Sklar,et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles , 1996, The Journal of experimental medicine.