Expression of the epidermal growth factor receptor family in normal and malignant urothelium

To compare the immunohistochemically assessed expression of the epidermal growth factor receptor (EGFR) family in normal and malignant bladder urothelium, and suggest new hypotheses about their function in the development and progression of transitional cell carcinoma (TCC).

[1]  L. Pike,et al.  Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking. , 2002, Biochemistry.

[2]  T. Sun,et al.  Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth. , 2002, Cancer research.

[3]  K. Sandvig,et al.  Sequestration of Epidermal Growth Factor Receptors in Non-caveolar Lipid Rafts Inhibits Ligand Binding* , 2002, The Journal of Biological Chemistry.

[4]  T. Golde,et al.  γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase , 2001, Science.

[5]  D. Grignon,et al.  Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[6]  L. Caskey,et al.  HER4 Mediates Ligand-Dependent Antiproliferative and Differentiation Responses in Human Breast Cancer Cells , 2001, Molecular and Cellular Biology.

[7]  T. Tzai,et al.  Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[8]  A. Ullrich,et al.  The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. , 2001, Endocrine-related cancer.

[9]  J. Määttä,et al.  Erbb4 and its isoforms: selective regulation of growth factor responses by naturally occurring receptor variants. , 2000, Trends in cardiovascular medicine.

[10]  A. Nouri,et al.  Profile of epidermal growth factor receptor (EGFr) expression in human malignancies: effects of exposure to EGF and its biological influence on established human tumour cell lines. , 2000, International journal of molecular medicine.

[11]  A. Charchanti,et al.  Immunohistochemical expression of retinoblastoma gene product (Rb), p53 protein, MDM2, c-erbB-2, HLA-DR and proliferation indices in human urinary bladder carcinoma. , 2000, Histology and histopathology.

[12]  L. Sobin,et al.  Histological Typing of Urinary Bladder Tumours , 1999, International Histological Classification of Tumours.

[13]  P. Bross,et al.  Expression of transforming growth factor alpha and epidermal growth factor receptor in human bladder cancer. , 1999, Scandinavian journal of clinical and laboratory investigation.

[14]  C. Busch,et al.  Expression of epidermal growth factor receptor in urinary bladder cancer metastases , 1998, International journal of cancer.

[15]  R. Poulsom,et al.  Expression of the c‐erbB‐4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types , 1998, The Journal of pathology.

[16]  Z. Kırkalı,et al.  Investigation of p53, c-erbB-2, PCNA immunoreactivity, DNA content, AgNOR and apoptosis in bladder carcinoma as prognostic parameters. , 1998, Cancer letters.

[17]  Hsiao‐Bai Yang,et al.  Expression patterns of erbB receptor family in normal urothelium and transitional cell carcinoma , 1997, Virchows Archiv.

[18]  N. Hynes,et al.  ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling , 1997, The EMBO journal.

[19]  G. Stamp,et al.  EXPRESSION OF THE TYPE 1 TYROSINE KINASE GROWTH FACTOR RECEPTORS EGF RECEPTOR, c‐erbB2 AND c‐erbB3 IN BLADDER CANCER , 1996, The Journal of pathology.

[20]  Y. Yarden,et al.  An Immunological Approach Reveals Biological Differences between the Two NDF/Heregulin Receptors, ErbB-3 and ErbB-4 (*) , 1996, The Journal of Biological Chemistry.

[21]  P. Carroll,et al.  Heterogeneity of erbB-2 gene amplification in bladder cancer. , 1993, Cancer research.

[22]  Y. Yazaki,et al.  c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. , 1993, Biochemical and biophysical research communications.

[23]  T. Akiyama,et al.  An immunohistologic evaluation of C‐erbB‐2 gene product in patients with urinary bladder carcinoma , 1992, Cancer.

[24]  N. Lemoine,et al.  Expression of the c-erbB-3 protein in normal human adult and fetal tissues. , 1992, Oncogene.

[25]  C. Cordon-Cardo,et al.  Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues. , 1990, Oncogene.

[26]  E. Messing.  Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma. , 1990, Cancer research.

[27]  E. Messing,et al.  Epidermal growth factor--interactions with normal and malignant urothelium: in vivo and in situ studies. , 1987, The Journal of urology.

[28]  B. Gusterson,et al.  Cellular localisation of human epidermal growth factor receptor. , 1984, Cell biology international reports.

[29]  I sabel Mortara,et al.  International Union against Cancer , 1938, Nature.

[30]  D. Grignon,et al.  Evaluation of epidermal growth factor receptor, transforming growth factor alpha, epidermal growth factor and c-erbB2 in the progression of invasive bladder cancer , 2004, Urological Research.

[31]  H. Grossman,et al.  Differential expression of progression-related genes in the evolution of superficial to invasive transitional cell carcinoma of the bladder. , 2001, Oncology reports.

[32]  P. Korkolopoulou,et al.  The role of p53, MDM2 and c-erb B-2 oncoproteins, epidermal growth factor receptor and proliferation markers in the prognosis of urinary bladder cancer. , 1997, Pathology, research and practice.

[33]  W. Fair,et al.  Evaluation of epidermal growth factor receptor DNA amplification and mRNA expression in bladder cancer. , 1992, Journal of Urology.