AD MCI). Observed agreement between readers was higher than chance but still lower than expected (Fleiss kappa 1⁄4 0.66 6 0.09 (95% CI: 0.61-0.71), p < 0.001). Six of the cases who were classified as negative based on the visual assessment, were classified as amyloid positive based on the semiquantitative threshold. No discordant cases were found in the visually assessed amyloid positive group (Figure 1). Conclusions: 21% vs. 37 % of MCI cases were amyloid-positive based on visual reads versus semiquantitative assessment, respectively. Semiquantitative methods might thus be more sensitive to detect amyloid burden in a mild disease stage compared with standard visual assessment.