Are we overrating the extra-skeletal benefits of oral vitamin D supplementation?

Vitamin D (Vit D) is a fat-soluble hormone poorly present in food, which is endogenously produced mainly through the biological conversion of its precursors into the biologically active form (1,25-dihydroxy-cholecalciferol) triggered by ultraviolet radiation exposure from either sunlight or, less frequently, indoor tanning (1).

[1]  J. Ware,et al.  Vitamin D Supplementation and Prevention of Type 2 Diabetes. , 2019, The New England journal of medicine.

[2]  W. März,et al.  Vitamin D testing and treatment: a narrative review of current evidence , 2019, Endocrine connections.

[3]  J. Manson,et al.  Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease , 2019, The New England journal of medicine.

[4]  R. Francis,et al.  Randomized controlled trial of vitamin D supplementation in older people to optimize bone health , 2019, The American journal of clinical nutrition.

[5]  J. Aloia,et al.  Safety of calcium and vitamin D supplements, a randomized controlled trial , 2018, Clinical endocrinology.

[6]  Ravinder J. Singh,et al.  Development of Vitamin D Toxicity from Overcorrection of Vitamin D Deficiency: A Review of Case Reports , 2018, Nutrients.

[7]  M. Hiligsmann,et al.  Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper , 2018, Front. Endocrinol..

[8]  R. Scragg Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation , 2018, Nutrients.

[9]  M. Daudon,et al.  Vitamin D, Hypercalciuria and Kidney Stones , 2018, Nutrients.

[10]  Alison D. Gernand,et al.  Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth. , 2018, The New England journal of medicine.

[11]  G. Lippi,et al.  Indoor Tanning a Gianus Bifrons: Vitamin D and Human Cancer. , 2018, Advances in clinical chemistry.

[12]  P. Lips,et al.  Global Overview of Vitamin D Status. , 2017, Endocrinology and metabolism clinics of North America.

[13]  N. Heureux Vitamin D Testing-Where Are We and What Is on the Horizon? , 2017, Advances in clinical chemistry.

[14]  G. Lippi,et al.  The impact of seasonality and other determinants on vitamin D concentration in childhood and adulthood: still an unresolved issue. , 2016, Annals of translational medicine.

[15]  C. Palacios,et al.  Is vitamin D deficiency a major global public health problem? , 2014, The Journal of Steroid Biochemistry and Molecular Biology.

[16]  T. Fang,et al.  The Pleiotropic Effect of Vitamin D , 2013, ISRN nephrology.

[17]  W. Willett,et al.  A pooled analysis of vitamin D dose requirements for fracture prevention. , 2012, The New England journal of medicine.

[18]  G. Lippi,et al.  Vitamin D, Thrombosis, and Hemostasis: More than Skin Deep , 2012, Seminars in Thrombosis & Hemostasis.

[19]  C. Gordon,et al.  Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. , 2011, The Journal of clinical endocrinology and metabolism.

[20]  M. Holick Resurrection of vitamin D deficiency and rickets. , 2006, The Journal of clinical investigation.