论文信息 - Synthesis of [6‐2H] and [6‐3H]fecapentaene‐12

Synthesis of [6‐2H] and [6‐3H]fecapentaene‐12

The title compounds (6 and 9) were prepared by exchange of the α-protons of (E,E)-2,4,-heptadienyldiphenylphosphine oxide (2) with either 2H2O or 3H2O, followed by condensations with (E,E)-5-[2,3-bis(t-butyldimethylsilyl) oxy]-propoxy-2,4-pentadienal (4) and deprotection.

D. Kingston | M. Z. Kassaee

[1] H. R. Pfaendler,et al. Synthesis of crystalline (.+-.)-fecapentaene , 1986 .

[2] D. Kingston,et al. Isolation and structure elucidation of fecapentaenes-12, potent mutagens from human feces. , 1985, Journal of natural products.

[3] A. D. Gen,et al. Synthesis of the E‐ and Z‐isomers of the potent mutagen (S)‐fecapentaene‐12 by the Horner‐Wittig reaction , 1985 .

[4] W. R. Bruce,et al. Structures of fecapentaenes, the mutagens of bacterial origin isolated from human feces. , 1983, Biochemistry.

[5] D. Kingston,et al. Synthesis of racemic fecapentaene-12, a potent mutagen from human feces, and its regioisomer , 1983 .

[6] D. Kingston,et al. Structure elucidation of a potent mutagen from human feces , 1982 .

[7] M. Ehrich,et al. Mutagens in the feces of 3 South-African populations at different levels of risk for colon cancer. , 1979, Mutation research.