Kinetics of hypogammaglobulinemia in patients with common variable immunodeficiency

We investigated the production of immunoglobulin (Ig) in six patients with common variable immunodeficiency and analyzed the courses of their levels of serum Ig for a period of 8–13 years. In all patients, levels of serum IgM, IgG and IgA were markedly low at the first examination, except for the IgM level in one patient. Improvement of serum Ig levels was observed in the patients in whom Ig production of non‐T cells at the first examination and Cμ gene expression had been detected to a slight degree, but serum Ig levels remained low in the patients in whom Ig production of non‐T cells and Cμ gene expression had not been detected. Our results suggest that some hypogammaglobulinemia in common variable immunodeficiency develops or improves with age.

[1]  P. Aucouturier,et al.  Changes in serum immunoglobulin patterns in adults with common variable immunodeficiency , 1991, Clinical and experimental immunology.

[2]  D. Kitamura,et al.  Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage. , 1989, Nucleic acids research.

[3]  M. Walter,et al.  Complete physical map of the human immunoglobulin heavy chain constant region gene complex. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Y. Saeki,et al.  Dissociation in the production of B cell-stimulating factors (BCGF and BCDF) and interleukin 2 by T cells from a common variable immunodeficient patient. , 1984, Journal of immunology.

[5]  L. Silengo,et al.  Multiple gene deletions within the human immunoglobulin heavy-chain cluster. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[6]  N. Kondo,et al.  Competence of B cells for T-cell help in pokeweed mitogen-induced immunoglobulin production. , 1983, Clinical immunology and immunopathology.

[7]  J. Flanagan,et al.  Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and α genes , 1982, Nature.

[8]  C. Cunningham-Rundles,et al.  Three distinct stages of B-cell defects in common varied immunodeficiency. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[9]  T. Honjo,et al.  Cloning of human immunoglobulin mu gene and comparison with mouse mu gene. , 1980, Nucleic acids research.

[10]  E. Schneeberger,et al.  Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia. , 1976, The Journal of clinical investigation.

[11]  R. Geha,et al.  Heterogeneity of "acquired" or common variable agammaglobulinemia. , 1974, The New England journal of medicine.

[12]  C. Griscelli,et al.  Immunoglobulins on the surface of lymphocytes in fifty patients with primary immunodeficiency diseases. , 1973, Clinical immunology and immunopathology.

[13]  E. Stiehm,et al.  "Acquired" agammaglobulinemia with defective delayed hypersensitivity. , 1968, Annals of internal medicine.

[14]  C. Janeway,et al.  The gamma globulins. 3. The antibody deficiency syndromes. , 1966, The New England journal of medicine.

[15]  C. Janeway,et al.  The gamma globulins. , 1966, Advances in pediatrics.