Finite element analyses for optimization design of biodegradable magnesium alloy stent.

Stents made of biodegradable magnesium alloys are expected to provide a temporary opening into a narrowed arterial vessel until it remodels and will progressively disappear thereafter. Inferior mechanical properties and fast corrosion of the magnesium alloys are the two crucial factors that impede the clinical application of the magnesium alloy stents (MAS). In the present study, gradual strut width, addition of the peak-to-valley unit and introduction of the annealing technology were designed and investigated by finite element analysis in order to improve the performance of the MAS. Two experiments were carried out for a preliminary validation of the simulation.

[1]  Jie Zhou,et al.  Multipass cold drawing of magnesium alloy minitubes for biodegradable vascular stents. , 2013, Materials science & engineering. C, Materials for biological applications.

[2]  Min Qi,et al.  An FEA method to study flexibility of expanded coronary stents , 2007 .

[3]  Peter J. Uggowitzer,et al.  High-strength magnesium alloys for degradable implant applications , 2011 .

[4]  P. E. McHugh,et al.  Comparing coronary stent material performance on a common geometric platform through simulated bench testing. , 2012, Journal of the mechanical behavior of biomedical materials.

[5]  R. Pakala,et al.  Serial imaging and histology illustrating the degradation of a bioabsorbable magnesium stent in a porcine coronary artery. , 2008, European heart journal.

[6]  D. Mantovani,et al.  Developments in metallic biodegradable stents. , 2010, Acta biomaterialia.

[7]  J. Seitz,et al.  Characterization of MgNd2 alloy for potential applications in bioresorbable implantable devices. , 2012, Acta biomaterialia.

[8]  Giuseppe Musumeci,et al.  Localized Hypersensitivity and Late Coronary Thrombosis Secondary to a Sirolimus-Eluting Stent: Should We Be Cautious? , 2004, Circulation.

[9]  Marc D Feldman,et al.  Coronary stents: a materials perspective. , 2007, Biomaterials.

[10]  Zhang-zhong Wang,et al.  Improvement of mechanical properties and corrosion resistance of biodegradable Mg–Nd–Zn–Zr alloys by double extrusion , 2012 .

[11]  Yufeng Zheng,et al.  Effects of alloying elements (Mn, Co, Al, W, Sn, B, C and S) on biodegradability and in vitro biocompatibility of pure iron. , 2011, Acta biomaterialia.

[12]  Raimund Erbel,et al.  Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial , 2007, The Lancet.

[13]  U. Sigwart.  The 1996 Grüntzig Lecture. Stents: a mechanical solution for a biological problem? , 1997, European heart journal.

[14]  Sanjay Pant,et al.  Geometry parameterization and multidisciplinary constrained optimization of coronary stents , 2011, Biomechanics and Modeling in Mechanobiology.

[15]  Liguo Wang,et al.  The microstructure and properties of cyclic extrusion compression treated Mg-Zn-Y-Nd alloy for vascular stent application. , 2012, Journal of the mechanical behavior of biomedical materials.

[16]  P E McHugh,et al.  A corrosion model for bioabsorbable metallic stents. , 2011, Acta biomaterialia.

[17]  Lorenza Petrini,et al.  Finite element analyses for design evaluation of biodegradable magnesium alloy stents in arterial vessels , 2011 .

[18]  Frank Witte,et al.  Degradable biomaterials based on magnesium corrosion , 2008 .

[19]  Christian W Hamm,et al.  Nickel and molybdenum contact allergies in patients with coronary in-stent restenosis , 2000, The Lancet.

[20]  Michael Weyand,et al.  First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby , 2005, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[21]  F. Auricchio,et al.  Mechanical behavior of coronary stents investigated through the finite element method. , 2002, Journal of biomechanics.

[22]  Raimund Erbel,et al.  Drug-eluting bioabsorbable magnesium stent. , 2004, Journal of interventional cardiology.

[23]  D. Agrawal,et al.  In stent restenosis: bane of the stent era , 2006, Journal of Clinical Pathology.

[24]  A Haverich,et al.  Left main coronary artery fistula exiting into the right atrium , 2003, Heart.

[25]  Wei Wu,et al.  Topology optimization of a novel stent platform with drug reservoirs. , 2008, Medical engineering & physics.

[26]  Raimund Erbel,et al.  Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, first-in-man BIOSOLVE-I trial , 2013, The Lancet.

[27]  Diego Mantovani,et al.  Experimental data confirm numerical modeling of the degradation process of magnesium alloys stents. , 2013, Acta biomaterialia.

[28]  Ron Waksman,et al.  Update on bioabsorbable stents: from bench to clinical. , 2006, Journal of interventional cardiology.

[29]  Wei Wu,et al.  Finite Element Shape Optimization for Biodegradable Magnesium Alloy Stents , 2010, Annals of Biomedical Engineering.

[30]  Q. Peng,et al.  Effects of backward extrusion on mechanical and degradation properties of Mg-Zn biomaterial. , 2012, Journal of the mechanical behavior of biomedical materials.

[31]  M. Leon,et al.  Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study. , 1996, Circulation.

[32]  R. Willumeit,et al.  Influence of ageing treatment on microstructure, mechanical and bio-corrosion properties of Mg-Dy alloys. , 2012, Journal of the mechanical behavior of biomedical materials.

[33]  J. A. Grogan,et al.  Optimizing the design of a bioabsorbable metal stent using computer simulation methods. , 2013, Biomaterials.

[34]  Frank Witte,et al.  In vitro and in vivo corrosion measurements of magnesium alloys. , 2006, Biomaterials.