Disease as a Consequence o f Deve lopmenta l Abnormal

From the *Department of lmmunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173, Precursory Research for Embryonic Science and Technology (PRESTO), Research and Development Corporation of Japan (]RDC), and the Institute of Physical and Chemical Research (RIKEN), Tsukuba Life Science Center, Tsukuba 305; and the aDepartment of Medicine, Juntendo University School of Medicine, Tokyo 113,Japan

[1]  K. Tung,et al.  Tolerance mechanism in experimental ovarian and gastric autoimmune diseases. , 1992, Journal of immunology.

[2]  K. Tung,et al.  Neonatal thymectomy results in a repertoire enriched in T cells deleted in adult thymus. , 1989, Science.

[3]  K. Tung,et al.  Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Immunopathology. , 1987, The American journal of pathology.

[4]  E. Shevach,et al.  The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. , 1984, Journal of immunology.

[5]  S. Sakaguchi,et al.  Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. , 1989, Journal of immunology.

[6]  S. Sakaguchi,et al.  Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease , 1985, The Journal of experimental medicine.

[7]  J. Bluestone,et al.  Identification of a monoclonal antibody specific for a murine T3 polypeptide. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[8]  J. Lowenthal,et al.  High and low affinity IL 2 receptors: analysis by IL 2 dissociation rate and reactivity with monoclonal anti-receptor antibody PC61. , 1985, Journal of immunology.

[9]  L. Nelson,et al.  Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy , 1990, The Journal of experimental medicine.

[10]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[11]  J. Sprent,et al.  Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity , 1990, Cell.

[12]  Y. Eishi,et al.  Developmental expression of autoimmune target antigens during organogenesis. , 1991, Immunology.

[13]  T. Winkler,et al.  IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. , 1994, International immunology.

[14]  G. Morahan,et al.  T cell tolerance and autoimmunity. , 1997, Ciba Foundation symposium.

[15]  R. A. Phillips,et al.  B Lymphocyte development , 2022 .

[16]  J. Sprent,et al.  A monoclonal antibody discriminating between subsets of T and B cells. , 1981, Journal of immunology.

[17]  T. Sakakura,et al.  Spontaneous development of autoimmune thyroiditis in neonatally thymectomized mice. , 1976, Laboratory investigation; a journal of technical methods and pathology.

[18]  Y. Nishizuka,et al.  Experimental autoimmune orchitis after neonatal thymectomy in the mouse. , 1981, Clinical and experimental immunology.

[19]  C. Boitard,et al.  T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice , 1989, The Journal of experimental medicine.

[20]  K. Kuribayashi,et al.  Germ-free condition and the susceptibility of BALB/c mice to post-thymectomy autoimmune gastritis. , 1992, Autoimmunity.

[21]  T. Takahashi,et al.  Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis , 1982, The Journal of experimental medicine.

[22]  T. Sakakura,et al.  Autoimmune oophoritis in thymectomized mice: detection of circulating antibodies against oocytes. , 1980, Clinical and experimental immunology.

[23]  Z. Ciko [Autoimmunity and autoimmune diseases]. , 1970, Vojnosanitetski pregled.

[24]  R. Zinkernagel,et al.  Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity , 1989, The Journal of experimental medicine.

[25]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[26]  S. Sakaguchi,et al.  Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer , 1982, The Journal of experimental medicine.

[27]  A. Nishio,et al.  Effects of intrathymic injection of organ‐specific autoantigens, parietal cells, at the neonatal stage on autoreactive effector and suppressor T cell precursors , 1993, European journal of immunology.

[28]  P. Gleeson,et al.  An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus , 1993, The Journal of experimental medicine.

[29]  Y. Kohno,et al.  Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis. , 1988, Journal of immunology.

[30]  S. Morse,et al.  T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases. , 1996, Journal of autoimmunity.

[31]  R. Good,et al.  Postthymectomy wasting associated with autoimmune phenomena. I. Antiglobulin-positive anemia in A and C57BL-6 Ks mice. , 1967 .

[32]  L. Old,et al.  Alloantigen-induced T-cell proliferation: Lyt phenotype of responding cells and blocking of proliferation by Lyt antisera. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[33]  W. Lee,et al.  Memory B and T cells. , 1991, Annual review of immunology.

[34]  E. Shevach,et al.  Premature escape of double-positive thymocytes to the periphery of young mice. Possible role in autoimmunity. , 1994, Journal of immunology.

[35]  H. Pircher,et al.  Lower receptor avidity required for thymic clonal deletion than for effector T-cell function , 1991, Nature.

[36]  G. Wick,et al.  Spontaneous thyroiditis in the obese strain of chickens. IV. The effect of thymectomy and thymo-bursectomy on the development of the disease. , 1970, Journal of immunology.

[37]  L. Herzenberg,et al.  Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens * , 1979, Immunological reviews.

[38]  M. Croft,et al.  Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development , 1991, Immunological reviews.

[39]  J. West,et al.  A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines , 1989, European journal of immunology.

[40]  K. Tung,et al.  Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Autoantibodies. , 1987, The American journal of pathology.

[41]  D. Gallina,et al.  Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat , 2005, Diabetologia.

[42]  Y. Nishizuka,et al.  Experimental production of possible autoimmune castritis followed by macrocytic anemia in athymic nude mice. , 1980, Laboratory investigation; a journal of technical methods and pathology.

[43]  S. Sakaguchi,et al.  Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease , 1990, The Journal of experimental medicine.

[44]  R. Prehn,et al.  Genetic susceptibility to post-thymectomy autoimmune diseases in mice , 1981, Immunogenetics.