The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling

[1]  K. Hochedlinger,et al.  Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro , 2023, Nature Cell Biology.

[2]  H. Tilg,et al.  The metabolic nature of inflammatory bowel diseases , 2022, Nature Reviews Gastroenterology & Hepatology.

[3]  Suzanne G. Orchard,et al.  Non-aspirin non-steroidal anti-inflammatory drugs in colorectal cancer: a review of clinical studies , 2022, British Journal of Cancer.

[4]  R. Legendre,et al.  PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms. , 2022, Cell stem cell.

[5]  E. Villablanca,et al.  Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression? , 2022, Nature Reviews Gastroenterology & Hepatology.

[6]  P. Zhu,et al.  Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons , 2022, Cell Research.

[7]  Kristin E. Burke,et al.  Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases: an International Organization for Study of Inflammatory Bowel Diseases consensus. , 2022, The lancet. Gastroenterology & hepatology.

[8]  A. van Oudenaarden,et al.  BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states. , 2022, Cell reports.

[9]  Eun Hye Kim,et al.  Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity , 2022, npj Precision Oncology.

[10]  P. Polgreen,et al.  Clinical Phenotypes of Cystic Fibrosis Carriers. , 2022, Annual review of medicine.

[11]  Yang Wang,et al.  The safety of MSC therapy over the past 15 years: a meta-analysis , 2021, Stem cell research & therapy.

[12]  Zhuo Wang,et al.  A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice , 2021, Science Translational Medicine.

[13]  H. Clevers,et al.  Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution. , 2021, Cell reports.

[14]  H. Clevers,et al.  Cell fate specification and differentiation in the adult mammalian intestine , 2020, Nature reviews. Molecular cell biology.

[15]  J. Jia,et al.  Natural COX-2 inhibitors as promising anti-inflammatory agents: an update. , 2020, Current medicinal chemistry.

[16]  R. Shivdasani,et al.  Cellular and molecular architecture of the intestinal stem cell niche , 2020, Nature Cell Biology.

[17]  H. Clevers,et al.  Intestinal Regeneration: Regulation by the Microenvironment. , 2020, Developmental cell.

[18]  Y. Kluger,et al.  Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche , 2020, Nature.

[19]  G. Núñez,et al.  Host–microbiota interactions in inflammatory bowel disease , 2020, Nature Reviews Immunology.

[20]  D. Aust,et al.  Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations , 2019, Gastroenterology.

[21]  Xuerui Yang,et al.  Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine , 2019, The Journal of experimental medicine.

[22]  Hans Clevers,et al.  Tales from the crypt: new insights into intestinal stem cells , 2018, Nature Reviews Gastroenterology & Hepatology.

[23]  Quin F. Wills,et al.  Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease , 2018, Cell.

[24]  K. Basler,et al.  GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells , 2018, Nature.

[25]  K. Sigmundsson,et al.  PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo , 2018, Proceedings of the National Academy of Sciences.

[26]  D. Gadsby,et al.  Molecular Structure of the Human CFTR Ion Channel , 2017, Cell.

[27]  P. Sansonetti,et al.  CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury , 2017, Proceedings of the National Academy of Sciences.

[28]  Bing Zhao,et al.  BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes , 2017, Nature Communications.

[29]  H. Miyoshi,et al.  Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium , 2017, The EMBO journal.

[30]  K. Ohtsuka,et al.  PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells , 2016, Scientific Reports.

[31]  A. Moor,et al.  Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis. , 2016, Cell reports.

[32]  K. Kaestner,et al.  Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell Niche , 2015, Cellular and molecular gastroenterology and hepatology.

[33]  K. Kang,et al.  Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2. , 2013, Gastroenterology.

[34]  Hans Clevers,et al.  A functional CFTR assay using primary cystic fibrosis intestinal organoids , 2013, Nature Medicine.

[35]  A. Sharif,et al.  Gliotransmission by Prostaglandin E2: A Prerequisite for GnRH Neuronal Function? , 2011, Front. Endocrin..

[36]  Hans Clevers,et al.  Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. , 2011, Gastroenterology.

[37]  Michael A McGuckin,et al.  Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria , 2010, The American Journal of Gastroenterology.

[38]  R. DuBois,et al.  The role of COX-2 in intestinal inflammation and colorectal cancer , 2010, Oncogene.

[39]  B. Tuch,et al.  β cell regeneration , 2008 .

[40]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[41]  Suet Yi Leung,et al.  Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors , 2007, Proceedings of the National Academy of Sciences.

[42]  Simon Smale,et al.  Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[43]  J. Fléjou,et al.  Abnormal Expression of Gastric Mucin in Human and Rat Aberrant Crypt Foci during Colon Carcinogenesis , 2003, Tumor Biology.

[44]  R. Flower What are all the things that aspirin does? , 2003, BMJ : British Medical Journal.

[45]  S. G. de la Fuente,et al.  Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats , 2003, Gut.

[46]  S. Hanauer,et al.  The pharmacokinetic profiles of oral mesalazine formulations and mesalazine pro‐drugs used in the management of ulcerative colitis , 2003, Alimentary pharmacology & therapeutics.

[47]  A. Ottani,et al.  Dual acting anti-inflammatory drugs: a reappraisal. , 2001, Pharmacological research.

[48]  R. Shaoul,et al.  The pathogenesis of duodenal gastric metaplasia: the role of local goblet cell transformation , 2000, Gut.

[49]  J. Vane,et al.  Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[50]  W. Falk,et al.  Interferon‐gamma (IFN‐γ)‐ and tumour necrosis factor (TNF)‐induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)‐induced colitis in mice , 1999, Clinical and experimental immunology.

[51]  C. Dooley,et al.  Prevalence of gastric metaplasia, inflammation, and Campylobacter pylori in the duodenum of members of a normal population. , 1988, American journal of clinical pathology.

[52]  D. Rampton,et al.  Prostaglandins and ulcerative colitis. , 1984, Gut.

[53]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[54]  R. Garavito,et al.  Cyclooxygenases: structural, cellular, and molecular biology. , 2000, Annual review of biochemistry.

[55]  N. Wright,et al.  Ulceration induces a novel epidermal growth factor-secreting cell lineage in human gastrointestinal mucosa. , 1990, Digestion.