论文信息 - A new immunosuppressive cyclic nonapeptide, cyclolinopeptide B from Linum usitatissimum

A new immunosuppressive cyclic nonapeptide, cyclolinopeptide B from Linum usitatissimum

Abstract A new cyclic nonapeptide, cyclolinopeptide B: cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Met-Leu-Ile-), has been isolated from the seeds of Linum usitatissimum and its structure was elucidated by extensive 2D NMR methods and chemical degradations. Cyclolinopeptide B showed potent immunosuppressive activity comparable with that of cyclosporin A. © 1997 Elsevier Science Ltd.

[1] F. Bovey,et al. Carbon-13 magnetic resonance spectroscopy. Spectrum of proline in oligopeptides , 1973 .

[2] H. Morita,et al. Conformation of cyclic heptapeptides: solid and solution state conformation of yunnanin A , 1997 .

[3] K. Kopple,et al. Conformation of cyclic peptides. 8. Cyclic hexapeptides containing the L-Pro-D-Phe sequence. , 1974, Journal of the American Chemical Society.

[4] H. Kaufmann,et al. Über ein Oligopeptid aus Leinsamen , 1959 .

[5] I. Siemion,et al. Immunosuppressive activity of cyclolinopeptide A. , 1991, Peptide research.

[6] Peter Marfey,et al. Determination ofD-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene , 1984 .

[7] Horst Kessler,et al. Peptide conformations. 46. Conformational analysis of a superpotent cytoprotective cyclic somatostatin analog , 1988 .