Identifying interaction motifs in CK2beta--a ubiquitous kinase regulatory subunit.

[1]  K. Mizuguchi,et al.  A novel mechanism of allosteric regulation of archaeal phosphoenolpyruvate carboxylase: a combined approach to structure-based alignment and model assessment. , 2006, Protein engineering, design & selection : PEDS.

[2]  M. Echeverria,et al.  An Extensive Survey of CK2 α and β Subunits in Arabidopsis: Multiple Isoforms Exhibit Differential Subcellular Localization , 2006 .

[3]  S. Artim,et al.  A novel protein kinase CK2 substrate indicates CK2 is not directly stimulated by polyamines in vivo. , 2006, Biochemistry.

[4]  L. Federici,et al.  The Polygalacturonase-Inhibiting Protein PGIP2 of Phaseolus vulgaris Has Evolved a Mixed Mode of Inhibition of Endopolygalacturonase PG1 of Botrytis cinerea1 , 2005, Plant Physiology.

[5]  L. Wiesmüller,et al.  The ‘regulatory’ β-subunit of protein kinase CK2 negatively influences p53-mediated allosteric effects on Chk2 activation , 2005, Oncogene.

[6]  D. Grunwald,et al.  Highlighting protein kinase CK2 movement in living cells , 2005, Molecular and Cellular Biochemistry.

[7]  L. Pinna,et al.  Autophosphorylation at the regulatory β subunit reflects the supramolecular organization of protein kinase CK2 , 2005, Molecular and Cellular Biochemistry.

[8]  O. Issinger,et al.  Primary and secondary interactions between CK2α and CK2β lead to ring-like structures in the crystals of the CK2 holoenzyme , 2005, Molecular and Cellular Biochemistry.

[9]  Hiroyoshi Matsumura,et al.  The Crystal Structure of the Outer Membrane Protein VceC from the Bacterial Pathogen Vibrio cholerae at 1.8 Å Resolution* , 2005, Journal of Biological Chemistry.

[10]  D. Litchfield,et al.  The Multiple Personalities of the Regulatory Subunit of Protein Kinase CK2: CK2 Dependent and CK2 Independent Roles Reveal a Secret Identity for CK2β , 2005, International journal of biological sciences.

[11]  C. Allende,et al.  Protein kinase casein kinase 2 holoenzyme produced ectopically in human cells can be exported to the external side of the cellular membrane. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[12]  K. Mizuguchi,et al.  A model of a transmembrane drug‐efflux pump from Gram‐negative bacteria , 2004, FEBS letters.

[13]  R. Abagyan,et al.  Optimal docking area: A new method for predicting protein–protein interaction sites , 2004, Proteins.

[14]  T. Blundell,et al.  Distinguishing structural and functional restraints in evolution in order to identify interaction sites. , 2004, Journal of molecular biology.

[15]  T. Blundell,et al.  Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop. , 2004, Acta crystallographica. Section D, Biological crystallography.

[16]  P. Højrup,et al.  Phosphorylation of the regulatory β‐subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2β phosphorylation site , 2004 .

[17]  R. Raz,et al.  ProMate: a structure based prediction program to identify the location of protein-protein binding sites. , 2004, Journal of molecular biology.

[18]  J. Ruderman,et al.  CK2 beta, which inhibits Mos function, binds to a discrete domain in the N-terminus of Mos. , 2004, Developmental biology.

[19]  J. Martiel,et al.  Protein kinase CK2: a new view of an old molecular complex , 2004, EMBO reports.

[20]  V. Bolanos-Garcia,et al.  Cell cycle regulatory protein p27KIP1 is a substrate and interacts with the protein kinase CK2 , 2004, Journal of cellular biochemistry.

[21]  R. Abagyan,et al.  Identification of protein-protein interaction sites from docking energy landscapes. , 2004, Journal of molecular biology.

[22]  O. Issinger,et al.  Modulation of human checkpoint kinase Chk1 by the regulatory β-subunit of protein kinase CK2 , 2003, Oncogene.

[23]  Y. Bae,et al.  Identification of mutations in protein kinase CKIIbeta subunit that affect its binding to ribosomal protein L41 and homodimerization. , 2003, Journal of biochemistry and molecular biology.

[24]  P. Højrup,et al.  Protein kinase CK2 phosphorylates the Fas‐associated factor FAF1 in vivo and influences its transport into the nucleus , 2003, FEBS letters.

[25]  J. Allende,et al.  Dual effect of lysine‐rich polypeptides on the activity of protein kinase CK2 , 2003, Journal of cellular biochemistry.

[26]  L. Pinna,et al.  One‐thousand‐and‐one substrates of protein kinase CK2? , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[27]  C. Souchier,et al.  Live-Cell Fluorescence Imaging Reveals the Dynamics of Protein Kinase CK2 Individual Subunits , 2003, Molecular and Cellular Biology.

[28]  O. Issinger,et al.  Disruption of the Regulatory β Subunit of Protein Kinase CK2 in Mice Leads to a Cell-Autonomous Defect and Early Embryonic Lethality , 2003, Molecular and Cellular Biology.

[29]  Sarah A. Teichmann,et al.  Principles of protein-protein interactions , 2002, ECCB.

[30]  D. Litchfield,et al.  Phosphorylation regulates the stability of the regulatory CK2β subunit , 2002, Oncogene.

[31]  C. Allende,et al.  The activity of CK2 in the extracts of COS-7 cells transfected with wild type and mutant subunits of protein kinase CK2 , 2001, Molecular and Cellular Biochemistry.

[32]  O. Issinger,et al.  Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme , 2001, The EMBO journal.

[33]  D. Litchfield,et al.  Assembly of protein kinase CK2: investigation of complex formation between catalytic and regulatory subunits using a zinc-finger-deficient mutant of CK2β , 2001 .

[34]  J. Allende,et al.  Protein p21WAF1/CIP1 is phosphorylated by protein kinase CK2 in vitro and interacts with the amino terminal end of the CK2 beta subunit , 2001, Journal of cellular biochemistry.

[35]  M. Frank-Vaillant,et al.  Interplay between Cdc2 kinase and the c-Mos/MAPK pathway between metaphase I and metaphase II in Xenopus oocytes. , 2001, Developmental biology.

[36]  Marco Antonio Boschetti,et al.  Cooperative modulation of protein kinase CK2 by separate domains of its regulatory beta-subunit. , 2000, Biochemistry.

[37]  G. Bren,et al.  PKC-?-associated CK2 participates in the turnover of free I?Ba 1 1 Edited by M. Yaniv , 2000 .

[38]  D. Litchfield,et al.  The Regulatory β Subunit of Protein Kinase CK2 Mediates Formation of Tetrameric CK2 Complexes* , 2000, Journal of Biological Chemistry.

[39]  O. Issinger,et al.  Protein kinase CK2: evidence for a protein kinase CK2β subunit fraction, devoid of the catalytic CK2α subunit, in mouse brain and testicles , 1999 .

[40]  E. Chambaz,et al.  Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger‐mediated dimerization , 1999, The EMBO journal.

[41]  A. Prowald,et al.  Regulation of p53 mediated transactivation by the β‐subunit of protein kinase CK2 , 1999, FEBS letters.

[42]  O. Issinger,et al.  Protein kinase CK2 and its role in cellular proliferation, development and pathology , 1999, Electrophoresis.

[43]  A. Kuo,et al.  Regulation of Casein Kinase 2 by Direct Interaction with Cell Surface Receptor CD5* , 1998, The Journal of Biological Chemistry.

[44]  J. Hériché,et al.  Binding of Polyamines to an Autonomous Domain of the Regulatory Subunit of Protein Kinase CK2 Induces a Conformational Change in the Holoenzyme , 1997, The Journal of Biological Chemistry.

[45]  Jonathan A. Cooper,et al.  The casein kinase II beta subunit binds to Mos and inhibits Mos activity , 1997, Molecular and cellular biology.

[46]  U. Rapp,et al.  The regulatory subunit of protein kinase CK2 is a specific A‐Raf activator , 1997, FEBS letters.

[47]  O. Issinger,et al.  A‐Raf kinase is a new interacting partner of protein kinase CK2 β subunit , 1997 .

[48]  E. Krebs,et al.  Specific Interaction between Casein Kinase 2 and the Nucleolar Protein Nopp140* , 1997, The Journal of Biological Chemistry.

[49]  F. Amalric,et al.  Fibroblast Growth Factor-2 Binds to the Regulatory β Subunit of CK2 and Directly Stimulates CK2 Activity toward Nucleolin* , 1996, The Journal of Biological Chemistry.

[50]  M. Montenarh,et al.  Mapping of the interaction sites of the growth suppressor protein p53 with the regulatory beta-subunit of protein kinase CK2. , 1995, Oncogene.

[51]  D. Litchfield,et al.  The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2. , 1995, Biochimica et biophysica acta.

[52]  W. Nastainczyk,et al.  Isolation and characterization of a monoclonal anti-protein kinase CK2 beta-subunit antibody of the IgG class for the direct detection of CK2 beta-subunit in tissue cultures of various mammalian species and human tumors. , 1995, Hybridoma.

[53]  E. Chambaz,et al.  Direct Identification of a Polyamine Binding Domain on the Regulatory Subunit of the Protein Kinase Casein Kinase 2 by Photoaffinity Labeling (*) , 1995, The Journal of Biological Chemistry.

[54]  O. Issinger,et al.  Phosphorylation and activation of protein kinase CK2 by p34cdc2 are independent events. , 1995, European journal of biochemistry.

[55]  C. Allende,et al.  Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[56]  O. Issinger,et al.  Asymmetric expression of protein kinase CK2 subunits in human kidney tumors. , 1994, Biochemical and biophysical research communications.

[57]  O. Issinger,et al.  Casein kinase 2 down-regulation and activation by polybasic peptides are mediated by acidic residues in the 55-64 region of the beta-subunit. A study with calmodulin as phosphorylatable substrate. , 1994, Biochemistry.

[58]  O. Issinger,et al.  Reconstitution of normal and hyperactivated forms of casein kinase-2 by variably mutated beta-subunits. , 1993, Biochemistry.

[59]  D. Morgan,et al.  Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[60]  E. Krebs,et al.  Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2. , 1991, The Journal of biological chemistry.

[61]  L. Pinna.  Casein kinase 2: an 'eminence grise' in cellular regulation? , 1990, Biochimica et biophysica acta.

[62]  E. Krebs,et al.  Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation , 1990, Nature.

[63]  T. Soderling.  Protein kinases. Regulation by autoinhibitory domains. , 1990, The Journal of biological chemistry.

[64]  E. Chambaz,et al.  Dissecting subdomains involved in multiple functions of the CK2β subunit , 2004, Molecular and Cellular Biochemistry.

[65]  C. Bendixen,et al.  Interactions of protein kinase CK2β subunit within the holoenzyme and with other proteins , 2004, Molecular and Cellular Biochemistry.

[66]  E. Chambaz,et al.  Searching interaction partners of protein kinase CK2β subunit by two-hybrid screening , 2004, Molecular and Cellular Biochemistry.

[67]  D. Litchfield.  Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. , 2003, The Biochemical journal.

[68]  Tal Pupko,et al.  Structural Genomics , 2005 .

[69]  W. Delano.  The PyMOL Molecular Graphics System , 2002 .

[70]  D. Litchfield,et al.  Assembly of protein kinase CK2: investigation of complex formation between catalytic and regulatory subunits using a zinc-finger-deficient mutant of CK2beta. , 2001, The Biochemical journal.

[71]  C. Bendixen,et al.  Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins. , 1999 .

[72]  C. Allende,et al.  Promiscuous subunit interactions: A possible mechanism for the regulation of protein kinase CK2 , 1998, Journal of cellular biochemistry.

[73]  B. Sefton,et al.  Protein kinases. , 1989, Cancer cells.