Sequential Metabolism of AMG 487, a Novel CXCR3 Antagonist, Results in Formation of Quinone Reactive Metabolites That Covalently Modify CYP3A4 Cys239 and Cause Time-Dependent Inhibition of the Enzyme
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D. Rock | R. Subramanian | G. Tonn | S. Wong | Michael G. Johnson | B. Wong | A. K. Mason | Y. Teffera | T. Tran | D. Stresser | Xiaoqi Chen | Brooke M. VandenBrink | K. Henne | Divesh Aidasani | Simon G. Wong | M. Johnson | Michael G. Johnson | Michael G. Johnson | Andrew K. Mason