Hybrid-artificial liver support system.

We originally developed a multi-capillary polyurethane foam packed-bed module as a hybrid-artificial liver support system (HALSS) and have applied for the permission of the clinical application to our institutional ethical committee. We summarized here the history, recent obstacles in clinical applications, and future prospects of HALSS, including our own.

[1]  J. Thompson,et al.  Acute and subacute fulminant hepatic failure: the role of liver transplantation , 1991, The Medical journal of Australia.

[2]  A. Demetriou,et al.  Clinical experience with a bioartificial liver in the treatment of severe liver failure. A phase I clinical trial. , 1997, Annals of surgery.

[3]  K. Sugimachi,et al.  Development of hybrid artificial liver support system using spheroid culture and application to warm ischemic liver failure in dog and pig as a preclinical test , 1998 .

[4]  C. Mullon,et al.  Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with a bioartificial liver support system. , 1999, Artificial organs.

[5]  T. Akaike,et al.  Expression of vascular endothelial growth factor promotes colonization, vascularization, and growth of transplanted hepatic tissues in the mouse , 1999, Hepatology.

[6]  Li Sd.  Liver transplantation for fulminant hepatic failure , 1993 .

[7]  Kohji Nakazawa,et al.  Hepatocyte Spheroids in Polyurethane Foams: Functional Analysis and Application for a Hybrid Artificial Liver , 1998 .

[8]  R Williams,et al.  Pilot‐controlled trial of the extracorporeal liver assist device in acute liver failure , 1996, Hepatology.

[9]  K. Sugimachi,et al.  The Efficacy of Nafamostat Mesilate on the Performance of a Hybrid-artificial Liver using a Polyurethane foam/porcine Hepatocyte Spheroid Culture System in Human Plasma , 2001, The International journal of artificial organs.

[10]  A. Osterhaus,et al.  An approach to the control of disease transmission in pig‐to‐human xenotransplantation , 2000, Xenotransplantation.

[11]  K Sugimachi,et al.  Modulation of immunologic reactions between cultured porcine hepatocytes and human sera. , 1999, ASAIO journal.

[12]  P. Opolon.  Large-Pore Hemodialysis in Fulminant Hepatic Failure , 1981 .

[13]  J. Burnell,et al.  Acute hepatic coma treated by cross-circulation or exchange transfusion. , 1967, The New England journal of medicine.

[14]  G. Abouna,et al.  Experience in the treatment of hepatic failure by intermittent liver hemoperfusions. , 1973, Surgery, gynecology & obstetrics.

[15]  W. Heneine,et al.  Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group. , 1999, Science.

[16]  H. Ijima,et al.  High albumin production by multicellular spheroids of adult rat hepatocytes formed in the pores of polyurethane foam , 1991, Applied Microbiology and Biotechnology.

[17]  R. Williams,et al.  Experiences in the treatment of fulminant hepatic failure by conservative therapy, charcoal haemoperfusion, and polyacrylonitrile haemodialysis. , 1978, The International journal of artificial organs.

[18]  N. Sussman,et al.  The Hepatix extracorporeal liver assist device: initial clinical experience. , 1994, Artificial organs.

[19]  D H Persing,et al.  Transfer of porcine endogenous retrovirus across hollow fiber membranes: significance to a bioartificial liver. , 1999, Transplantation.

[20]  T. Lie.  Extracorporeal hemoperfusion over the baboon and human liver to treat fulminant hepatitis and its bridge role for liver transplantation. , 1990 .

[21]  R. Hughes,et al.  Evaluation of the BioLogic-DT sorbent-suspension dialyser in patients with fulminant hepatic failure , 1994, The International journal of artificial organs.

[22]  K. Isono,et al.  Efficacy and limitations of plasma exchange in patients with acute hepatic failure; comparing with hemoadsorption, and with impaired regeneration syndrome. , 1991, Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology.

[23]  K. Yoshizato,et al.  Heterogeneity of growth potential of adult rat hepatocytes in vitro , 2000, Hepatology.

[24]  K Sugimachi,et al.  Evaluation of a hybrid artificial liver using a polyurethane foam packed-Bed culture system in dogs. , 1999, The Journal of surgical research.

[25]  F. Villamil,et al.  Early clinical experience with a hybrid bioartificial liver. , 1995, Scandinavian journal of gastroenterology. Supplement.

[26]  T. Mizuguchi,et al.  Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells , 1999, Hepatology.

[27]  W. Mars,et al.  Bone marrow as a potential source of hepatic oval cells. , 1999, Science.

[28]  P. W. Bowman,et al.  PHS Public Health Service , 1963 .

[29]  L. Vīksna,et al.  Temporary organ substitution by hemoperfusion through suspension of active donor hepatocytes in a total complex of intensive therapy in patients with acute hepatic insufficiency. , 1989, Resuscitation.

[30]  H. Mizumoto,et al.  Formation of a spherical multicellular aggregate (spheroid) of animal cells in the pores of polyurethane foam as a cell culture substratum and its application to a hybrid artificial liver. , 1998, Journal of biomaterials science. Polymer edition.

[31]  M. Sakaguchi,et al.  Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. , 2000, Science.

[32]  B. Torbett,et al.  Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice , 2000, Nature.

[33]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[34]  Y. Kamiyama,et al.  Clinical experience of postoperative hepatic failure treatment with pig or baboon liver cross-hemodialysis with an interposed membrane. , 1982, Artificial organs.

[35]  Kazuaki Inoue,et al.  Favorable effect of new artificial liver support on survival of patients with fulminant hepatic failure. , 2008, Artificial organs.

[36]  A. Gimson,et al.  Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. , 1988, Gastroenterology.

[37]  M. Sakaguchi,et al.  Treatment of Surgically Induced Acute Liver Failure with Transplantation of Highly Differentiated Immortalized Human Hepatocytes , 2000, Cell transplantation.

[38]  R Williams,et al.  Extracorporeal support and hepatocyte transplantation in acute liver failure and cirrhosis , 1999, Journal of gastroenterology and hepatology.

[39]  K. Sugimachi,et al.  Formation of porcine hepatocyte spherical multicellular aggregates (spheroids) and analysis of drug metabolic functions , 2004, Cytotechnology.

[40]  Yasuhiro Takeuchi,et al.  Infection of human cells by an endogenous retrovirus of pigs , 1997, Nature Medicine.

[41]  H. Nakauchi,et al.  Flow‐cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver , 2000, Hepatology.

[42]  T. Kawai,et al.  Living-related liver transplantation for fulminant hepatic failure. , 1997, Transplantation proceedings.

[43]  H. Lee,et al.  Development of a Non-Transformed Human Liver Cell Line with Differentiated-Hepatocyte and Urea-Synthetic Functions: Applicable for Bioartificial Liver , 1999, The International journal of artificial organs.

[44]  M. Rikimaru,et al.  Hybrid bioartificial liver in hepatic failure: preliminary clinical report. , 1987, Surgery.

[45]  Xin Wang,et al.  Purified hematopoietic stem cells can differentiate into hepatocytes in vivo , 2000, Nature Medicine.