Polymorphisms of the Fimbria fim3 Gene of Bordetella pertussis Strains Isolated in Canada

ABSTRACT The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.

[1]  Joseph Britto,et al.  Whooping cough—a continuing problem , 2002, BMJ : British Medical Journal.

[2]  F. Mooi,et al.  Multilocus Sequence Typing of Bordetella pertussis Based on Surface Protein Genes , 2002, Journal of Clinical Microbiology.

[3]  S. Thiberge,et al.  Thirty-five years' experience with the whole-cell pertussis vaccine in France: vaccine strains analysis and immunogenicity. , 2002, Vaccine.

[4]  C. Boursaux-Eude,et al.  Polymorphism of Bordetella pertussisIsolates Circulating for the Last 10 Years in France, Where a Single Effective Whole-Cell Vaccine Has Been Used for More than 30 Years , 2001, Journal of Clinical Microbiology.

[5]  I. V. van Loo,et al.  Temporal nucleotide changes in pertactin and pertussis toxin genes in Bordetella pertussis strains isolated from clinical cases in Poland. , 2001, Vaccine.

[6]  R. George,et al.  Genotypic Variation in the Bordetella pertussis Virulence Factors Pertactin and Pertussis Toxin in Historical and Recent Clinical Isolates in the United Kingdom , 2001, Infection and Immunity.

[7]  C. Boursaux-Eude,et al.  Analysis of Bordetella pertussis isolates collected in Japan before and after introduction of acellular pertussis vaccines. , 2001, Vaccine.

[8]  T. Popović,et al.  Polymorphism in Bordetella pertussis pertactin and pertussis toxin virulence factors in the United States, 1935-1999. , 2000, The Journal of infectious diseases.

[9]  D. Burns,et al.  Use of Pertussis Toxin Encoded by ptxGenes from Bordetella bronchiseptica To Model the Effects of Antigenic Drift of Pertussis Toxin on Antibody Neutralization , 2000, Infection and Immunity.

[10]  S. Thiberge,et al.  Intranasal murine model of Bordetella pertussis infection: II. Sequence variation and protection induced by a tricomponent acellular vaccine. , 1999, Vaccine.

[11]  F. Mooi,et al.  Polymorphism in the Bordetella pertussisVirulence Factors P.69/Pertactin and Pertussis Toxin in The Netherlands: Temporal Trends and Evidence for Vaccine-Driven Evolution , 1998, Infection and Immunity.

[12]  P Duclos,et al.  Estimates of the effectiveness of a whole-cell pertussis vaccine from an outbreak in an immunized population. , 1997, Vaccine.

[13]  F. Mooi,et al.  The major fimbrial subunit of Bordetella pertussis binds to sulfated sugars , 1996, Infection and immunity.

[14]  R. Matthews,et al.  Epitope mapping the Fim2 and Fim3 proteins of Bordetella pertussis with sera from patients infected with or vaccinated against whooping cough. , 1996, FEMS immunology and medical microbiology.

[15]  F. Mooi,et al.  Bordetella pertussis fimbriae bind to human monocytes via the minor fimbrial subunit FimD. , 1995, The Journal of infectious diseases.

[16]  N. Preston,et al.  Characterization of outbreak and vaccine strains of Bordetella pertussis--Quebec. , 1993, Canada communicable disease report = Releve des maladies transmissibles au Canada.

[17]  F. Mooi,et al.  Structure of the Bordetella pertussis gene coding for the serotype 3 fimbrial subunit. , 1990, FEMS microbiology letters.

[18]  D. Maclean,et al.  Persistence of pertussis in an immunized population: results of the Nova Scotia Enhanced Pertussis Surveillance Program. , 1989, The Journal of pediatrics.

[19]  A. Wardlaw,et al.  Pathogenesis and immunity in pertussis , 1988 .

[20]  J. Poolman,et al.  Whole‐cell ELISA for typing Neisseria meningitidis with monoclonal antibodies , 1987 .

[21]  C. J. Duggleby,et al.  Cloning and nucleotide sequence analysis of the serotype 2 fimbrial subunit gene of Bordetella pertussis , 1987, Molecular microbiology.

[22]  N. Preston.  CHANGE IN SEROTYPE OF PERTUSSIS INFECTION IN BRITAIN , 1985, The Lancet.

[23]  L. Irons,et al.  Antigenic Relationship Between Serotype-Specific Agglutinogen and Fimbriae of Bordetella pertussis , 1982, Infection and immunity.

[24]  S. Toma,et al.  Bordetella pertussis serotypes in Canada. , 1978, Canadian Medical Association journal.

[25]  F. Chan,et al.  Bordetella pertussis in the National Capital Region: prevalent serotype and immunization status of patients. , 1977, Canadian Medical Association journal.