Prohepcidin, B-Type Natriuretic Peptide, and Iron Status in a Cohort of Elderly Women from the Rhine-Ruhr Area

Air pollution on Lung function, Inflammation and Aging) cohort investigation. Therefore, prohepcidin, the 84-amino acid precursor of hepcidin, was determined by a commercial assay to be a potential surrogate marker for hepcidin which can be used in routine laboratory examination. Some studies have investigated the association between prohepcidin and parameters of iron status, with conflicting results [7–17] . According to our knowledge, this parameter has not yet been determined in a population of elderly women. Among different diseases associated with iron deficiency (ID) and anemia, anemia is common in patients with heart failure [18–20] . B-type natriuretic peptide (BNP) is a reliable marker of left ventricular dysfunction. Elevated BNP concentrations are associated with a poor outcome in patients with heart failure and coronary artery disease. Studies have shown that BNP concentrations in cardiac patients [21–23] and in the general population are inversely and independently related to Hb concentrations [24] . This suggests that elevated BNP concentraThe elderly constitute a fast growing segment of populations worldwide. Both anemia and iron overload have emerged as risk factors that are associated with a variety of adverse outcomes in older adults [1–5] . Standard laboratory parameters like serum ferritin (SF), transferrin, transferrin saturation (Tsat), serum iron (SI), Hb, MCV, and HCT are commonly used for the assessment of iron status, but rapid progress has been made in understanding the regulation of iron metabolism by the hepatic peptide hormone hepcidin [6] . Hepcidin is synthesized in response to elevated plasma iron stores, thus ensuring homeostasis. Hepcidin synthesis is also increased by infection and inflammation. Increased hepcidin concentrations are of major importance in anemia of inflammation and iron-resistant iron deficiency anemia (IDA). On the other hand hepcidin is decreased in diseases that are attended by iron overload like most hereditary hemochromatoses or iron-loading anemias. A commercial assay for the measurement of serum hepcidin was not available at the time of the SALIA (Study on the influence of Received: April 14, 2010 Accepted after revision: July 1, 2010 Published online: September 28, 2010

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