论文信息 - 1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors. - 字舞流文

1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors.

Replacement of the highly basic benzamidine moiety of NAPAP by the moderately basic 1-aminoisoquinoline moiety resulted in thrombin inhibitors with improved selectivity towards trypsin and enhanced Caco-2 cell permeability.

P. van Galen | C. V. van Boeckel | P J van Galen | J. Rewinkel | H. Lucas | A. Noach | T. van Dinther | A. Rood | A. Jenneboer | T G van Dinther | C A van Boeckel | J B Rewinkel | H Lucas | A B Noach | A M Rood | A J Jenneboer | P. J. van Galen

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