ancreatic exocrine insufficiency in pancreatic cancer : A review of the iterature ichael

Pancreatic exocrine insufficiency is a well-documented complication of chronic pancreatitis; however, study results of pancreatic exocrine insufficiency in pancreatic cancer are less consistent. This applies for vailable online 6 July 2015

[1]  C. V. van Eijck,et al.  Prospective assessment of the influence of pancreatic cancer resection on exocrine pancreatic function , 2014, The British journal of surgery.

[2]  C. V. van Eijck,et al.  A Prospective Assessment of the Natural Course of the Exocrine Pancreatic Function in Patients With a Pancreatic Head Tumor , 2013, Journal of clinical gastroenterology.

[3]  A. Andriulli,et al.  Exocrine pancreatic insufficiency in adults: a shared position statement of the Italian Association for the Study of the Pancreas. , 2013, World journal of gastroenterology.

[4]  S. Fieuws,et al.  Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: a multicentre randomised trial. , 2013, The Lancet. Oncology.

[5]  Yang Zhao,et al.  Pancreaticojejunostomy versus Pancreaticogastrostomy after Pancreaticoduodenectomy: A Systematic Review and Meta-Analysis , 2013, Digestive Surgery.

[6]  N. Reddy,et al.  A 51-week, open-label clinical trial in India to assess the efficacy and safety of pancreatin 40000 enteric-coated minimicrospheres in patients with pancreatic exocrine insufficiency due to chronic pancreatitis. , 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[7]  H. Friess,et al.  Randomised clinical trial: a 1-week, double-blind, placebo-controlled study of pancreatin 25 000 Ph. Eur. minimicrospheres (Creon 25000 MMS) for pancreatic exocrine insufficiency after pancreatic surgery, with a 1-year open-label extension , 2013, Alimentary pharmacology & therapeutics.

[8]  R. Micciolo,et al.  Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection. , 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[9]  C. Bassi,et al.  Faecal elastase-1 is an independent predictor of survival in advanced pancreatic cancer. , 2012, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[10]  E. Hiyama,et al.  Histological Loss of Pancreatic Exocrine Cells Correlates With Pancreatic Exocrine Function After Pancreatic Surgery , 2012, Pancreas.

[11]  N. Reddy,et al.  Randomised clinical trial: the efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis - a double-blind, placebo-controlled study , 2012, Alimentary pharmacology & therapeutics.

[12]  E. Kuipers,et al.  The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey , 2012, Journal of Gastrointestinal Surgery.

[13]  R. Pozzi Mucelli,et al.  Quantitative MRCP assessment of pancreatic exocrine reserve and its correlation with faecal elastase-1 in patients with chronic pancreatitis , 2012, La radiologia medica.

[14]  H. Ohge,et al.  Reduced pancreatic parenchymal thickness indicates exocrine pancreatic insufficiency after pancreatoduodenectomy. , 2011, The Journal of surgical research.

[15]  J. Neoptolemos,et al.  Partial Pancreatic Resection for Pancreatic Malignancy Is Associated with Sustained Pancreatic Exocrine Failure and Reduced Quality of Life: A Prospective Study , 2011, Pancreatology.

[16]  M. Armand,et al.  Enzyme replacement therapy for pancreatic insufficiency: present and future , 2011, Clinical and experimental gastroenterology.

[17]  S. Philcox A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery , 2011 .

[18]  J. Domínguez-Muñoz Pancreatic enzyme therapy for pancreatic exocrine insufficiency. , 2011, Gastroenterology & hepatology.

[19]  S. Caras,et al.  Pancrelipase Delayed-Release Capsules (CREON) for Exocrine Pancreatic Insufficiency due to Chronic Pancreatitis or Pancreatic Surgery: A Double-Blind Randomized Trial , 2010, The American Journal of Gastroenterology.

[20]  L. Traverso,et al.  Pancreatic Exocrine Function Is Preserved After Distal Pancreatectomy , 2010, Journal of Gastrointestinal Surgery.

[21]  S. Tariq,et al.  MRI and S‐MRCP findings in patients with suspected chronic pancreatitis: Correlation with endoscopic pancreatic function testing (ePFT) , 2010, Journal of magnetic resonance imaging : JMRI.

[22]  H. Ohge,et al.  Predictive Factors for Exocrine Pancreatic Insufficiency After Pancreatoduodenectomy with Pancreaticogastrostomy , 2009, Journal of Gastrointestinal Surgery.

[23]  W. Lees,et al.  Correlation of MRCP quantification (MRCPQ) with conventional non-invasive pancreatic exocrine function tests , 2008, Abdominal Imaging.

[24]  J. Sand,et al.  Obstructed pancreaticojejunostomy partly explains exocrine insufficiency after pancreatic head resection , 2007, Scandinavian journal of gastroenterology.

[25]  L. Traverso,et al.  Exocrine function following the whipple operation as assessed by stool elastase , 2006, Journal of Gastrointestinal Surgery.

[26]  H. Riediger,et al.  Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy is strongly related to other postoperative complications , 2003, Journal of Gastrointestinal Surgery.

[27]  M. Safdi,et al.  The Effects of Oral Pancreatic Enzymes (Creon 10 Capsule) on Steatorrhea: A Multicenter, Placebo-controlled, Parallel Group Trial in Subjects With Chronic Pancreatitis , 2006, Pancreas.

[28]  J. Holst,et al.  Inhibition of human pancreatic and biliary output but not intestinal motility by physiological intraileal lipid loads. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[29]  A. Figueiras,et al.  Effect of the administration schedule on the therapeutic efficacy of oral pancreatic enzyme supplements in patients with exocrine pancreatic insufficiency: a randomized, three‐way crossover study , 2005, Alimentary pharmacology & therapeutics.

[30]  Tetsuhide Ito,et al.  Plasma pancreastatin responses after intrajejunal infusion of liquid meal in patients with chronic pancreatitis , 1990, Digestive Diseases and Sciences.

[31]  W. Chey,et al.  Release of cholecystokinin and exocrine pancreatic secretion in response to an elemental diet in human subjects , 1986, Digestive Diseases and Sciences.

[32]  D. Graham An enteric-coated pancreatic enzyme preparation that works , 1979, Digestive Diseases and Sciences.

[33]  Masao Tanaka,et al.  Which is a Less Invasive Pancreatic Head Resection: PD, PPPD, or DPPHR? , 2001, Digestive Diseases and Sciences.

[34]  N. Sato,et al.  Short-Term and Long-Term Pancreatic Exocrine and Endocrine Functions After Pancreatectomy , 1998, Digestive Diseases and Sciences.

[35]  G. Tytgat,et al.  Gastric Transit and Pharmacodynamics of a Two-Millimeter Enteric-Coated Pancreatin Microsphere Preparation in Patients with Chronic Pancreatitis , 2004, Digestive Diseases and Sciences.

[36]  J. Keller,et al.  Pancreatic enzyme supplementation therapy , 2003, Current treatment options in gastroenterology.

[37]  Jin‐Young Jang,et al.  Comparison of the Functional Outcome after Pylorus-preservingPancreatoduodenectomy: Pancreatogastrostomy and Pancreatojejunostomy , 2002, World Journal of Surgery.

[38]  K. Lillemoe,et al.  Quality of life and outcomes after pancreaticoduodenectomy. , 2000, Annals of surgery.

[39]  A. Sauvanet,et al.  Functional and morphological changes in the pancreatic remnant following pancreaticoduodenectomy with pancreaticogastric anastomosis , 2000, The British journal of surgery.

[40]  J. Neoptolemos,et al.  Exocrine Pancreatic Function following Pancreatectomy , 1999, Annals of the New York Academy of Sciences.

[41]  A. Andrén-sandberg,et al.  Treatment of pancreatic exocrine insufficiency after pancreatic resection , 1999, International journal of pancreatology : official journal of the International Association of Pancreatology.

[42]  N. Sato,et al.  Duct-parenchymal ratio predicts exocrine pancreatic function after pancreatoduodenectomy and distal pancreatectomy. , 1998, American journal of surgery.

[43]  T. Moojen,et al.  Postoperative weight gain after standard Whipple's procedure versus pylorus‐preserving pancreatoduodenectomy: the influence of tumour status , 1998, The British journal of surgery.

[44]  G. Tytgat,et al.  Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region , 1998, Gut.

[45]  P. Hadváry,et al.  Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release. , 1998, Gastroenterology.

[46]  M. I. van Berge Henegouwen,et al.  Delayed gastric emptying after standard pancreaticoduodenectomy versus pylorus-preserving pancreaticoduodenectomy: an analysis of 200 consecutive patients. , 1997, Journal of the American College of Surgeons.

[47]  G. Tytgat,et al.  Comparative effects of enteric‐coated pancreatin microsphere therapy after conventional and pylorus‐preserving pancreatoduodenectomy , 1997, The British journal of surgery.

[48]  J. Lloyd-Still,et al.  High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. , 1997, The New England journal of medicine.

[49]  J. Holst,et al.  Altered postprandial motility in chronic pancreatitis: role of malabsorption. , 1997, Gastroenterology.

[50]  J. Keller,et al.  Duodenal and ileal nutrient deliveries regulate human intestinal motor and pancreatic responses to a meal. , 1997, The American journal of physiology.

[51]  M. Taubeneck,et al.  Efficacy of Enzyme Supplementation After Surgery for Chronic Pancreatitis , 1997, Pancreas.

[52]  L. Gullo,et al.  Tolerability and safety of the long-term administration of pancreatic extracts. , 1997, Pancreas.

[53]  R. Guimbaud,et al.  Intraduodenal Free Fatty Acids Rather than Triglycerides Are Responsible for the Release of CCK in Humans , 1997, Pancreas.

[54]  A. Smyth,et al.  Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes , 1994, The Lancet.

[55]  I. Miyazaki,et al.  Pancreatic Exocrine Insufficiency after Pancreatic Surgery Detected by Tubeless Testing , 1994 .

[56]  P. Layer,et al.  Modulation of Human Periodic Interdigestive Gastrointestinal Motor and Pancreatic Function by the Ileum , 1993, Pancreas.

[57]  A. Nakao,et al.  13C-labeled trioctanoin breath test for exocrine pancreatic function test in patients after pancreatoduodenectomy. , 1993, The American journal of gastroenterology.

[58]  N. Vidon,et al.  Fate of orally ingested enzymes in pancreatic insufficiency: comparison of two pancreatic enzyme preparations , 1991, Alimentary pharmacology & therapeutics.

[59]  B. Gayet,et al.  [Endoscopic ultrasonography of the bile ducts]. , 1990, Annales de chirurgie.

[60]  M. Braga,et al.  Pancreatic enzyme replacement therapy in post-pancreatectomy patients. , 1989, International journal of pancreatology : official journal of the International Association of Pancreatology.

[61]  J. Meyer,et al.  Temporal relationships of cholecystokinin release, pancreatobiliary secretion, and gastric emptying of a mixed meal. , 1988, Gastroenterology.

[62]  J. Elashoff,et al.  Human postprandial gastric emptying of 1-3-millimeter spheres. , 1988, Gastroenterology.

[63]  K. Dohi,et al.  Clinical and experimental study of pancreatic exocrine function after pancreaticoduodenectomy for periampullary carcinoma. , 1988, Surgery, gynecology & obstetrics.

[64]  L. Way,et al.  Gastric emptying and small bowel transit of solid food after pylorus-preserving pancreaticoduodenectomy. , 1987, Archives of surgery.

[65]  B. Lembcke,et al.  Therapy of pancreatogenic steatorrhoea: does acid protection of pancreatic enzymes offer any advantage? , 1986, Zeitschrift fur Gastroenterologie.

[66]  N. T. Pedersen,et al.  Symptomatic effect of pancreatic enzyme therapy in patients with chronic pancreatitis. , 1986, Scandinavian journal of gastroenterology.

[67]  G. Amidon,et al.  Effect of size and density on canine gastric emptying of nondigestible solids. , 1985, Gastroenterology.

[68]  C. Beglinger,et al.  Pancreatic enzyme response to a liquid meal and to hormonal stimulation. Correlation with plasma secretin and cholecystokinin levels. , 1985, The Journal of clinical investigation.

[69]  W. Domschke,et al.  Pancreatic enzyme replacement therapy: comparative effects of conventional and enteric-coated microspheric pancreatin and acid-stable fungal enzyme preparations on steatorrhoea in chronic pancreatitis. , 1985, Hepato-gastroenterology.

[70]  A. Warshaw,et al.  Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy. , 1985, Surgery, gynecology & obstetrics.

[71]  P. Maton,et al.  Sham feeding and pancreatic secretion. Evidence for direct vagal stimulation of enzyme output. , 1984, Gastroenterology.

[72]  M. Kodama,et al.  Residual function of exocrine pancreas after operation for chronic pancreatitis by N-benzoyl-L-tyrosyl-p-aminobenzoic acid test (NBT-PABA test). , 1984, Digestion.

[73]  E. Dimagno,et al.  Assessment of weight loss, food intake, fat metabolism, malabsorption, and treatment of pancreatic insufficiency in pancreatic cancer , 1983, Cancer.

[74]  S. Dutta,et al.  Comparative evaluation of the therapeutic efficacy of a pH-sensitive enteric coated pancreatic enzyme preparation with conventional pancreatic enzyme therapy in the treatment of exocrine pancreatic insufficiency. , 1983, Gastroenterology.

[75]  J. Ruggiero,et al.  Clinical effectiveness of a pancreatic enzyme supplement. , 1981, JPEN. Journal of parenteral and enteral nutrition.

[76]  E. Dimagno,et al.  The relationships between pancreatic ductal obstruction and pancreatic secretion in man. , 1979, Mayo Clinic proceedings.

[77]  L. Miller,et al.  Control of human postprandial pancreatic exocrine secretion: a function of the gastroduodenal region. , 1979, Digestive diseases and sciences.

[78]  E. Dimagno,et al.  Prospective evaluation of the pancreatic secretion of immunoreactive carcinoembryonic antigen, enzyme, and bicarbonate in patients suspected of having pancreatic cancer. , 1977, Gastroenterology.

[79]  F. Stapleton,et al.  Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. , 1977, The Journal of pediatrics.

[80]  I. Ihse,et al.  Intestinal activities of trypsin, lipase, and phospholipase after a test meal. An evaluation of 474 examinations. , 1977, Scandinavian journal of gastroenterology.

[81]  G. Skude,et al.  Time-related enzyme concentrations in duodenal aspirates after ingestion of a test meal. , 1977, Scandinavian journal of gastroenterology.

[82]  A. Delcourt,et al.  Functional exploration of chronic pancreatitis by duodenal intubation. Comparative study of the Lundh meal and duodenal hormones based on a survey of literature. Secretin-caerulein test carried out by the authors. Prospective conclusions. , 1976, Acta gastro-enterologica Belgica.

[83]  E. Dimagno,et al.  Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. , 1973, The New England journal of medicine.

[84]  Dreiling Da The early diagnosis of pancreatic cancer. , 1970 .

[85]  T. T. White,et al.  The effect of gastric distension on duodenal aspirates in man. , 1963, Gastroenterology.