Diet and inflammation: a link to metabolic and cardiovascular diseases.

Both epidemiological studies and intervention trials support an important role of diet in reducing the risk of a variety of chronic diseases, including cardiovascular disease, and overall mortality. We discuss available evidence indicating that the generation of a pro-inflammatory milieu might be one mechanism through which unhealthy diets are linked to metabolic and cardiovascular diseases. In practical terms, fully understanding the link between diet and inflammation holds the premise to elucidate the mechanisms by which dietary patterns improve cardiovascular health.

[1]  D. Kromhout,et al.  Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: The HALE project , 2005 .

[2]  R. Marfella,et al.  Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. , 2004, JAMA.

[3]  D. Annane,et al.  Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis , 2004, BMJ : British Medical Journal.

[4]  J. Pankow,et al.  Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study. , 2004, Diabetes care.

[5]  P. Bowen,et al.  Postprandial lipid oxidation and cardiovascular disease risk , 2004, Current atherosclerosis reports.

[6]  The role of antioxidants in preventive cardiology. , 1997, Current opinion in cardiology.

[7]  J. Manson,et al.  Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. , 2004, JAMA.

[8]  A. Aljada,et al.  Contemporary Reviews in Cardiovascular Medicine Metabolic Syndrome A Comprehensive Perspective Based on Interactions Between Obesity, Diabetes, and Inflammation , 2022 .

[9]  J. Després,et al.  Treatment of obesity: need to focus on high risk abdominally obese patients , 2001, BMJ : British Medical Journal.

[10]  A. Ceriello,et al.  Role of hyperglycemia in nitrotyrosine postprandial generation. , 2002, Diabetes care.

[11]  S. Grundy.  Obesity, metabolic syndrome, and coronary atherosclerosis. , 2002, Circulation.

[12]  D. Giugliano,et al.  The metabolic syndrome and inflammation: association or causation? , 2004, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[13]  A. Hamsten,et al.  Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine. , 2001, Journal of the American College of Cardiology.

[14]  M. de Lorgeril,et al.  Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. , 1999, Circulation.

[15]  D. Giugliano,et al.  Effect of Atorvastatin and Irbesartan, Alone and in Combination, on Postprandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetic Patients , 2005, Circulation.

[16]  C. Bouchard,et al.  Modifications in food-group consumption are related to long-term body-weight changes. , 2004, The American journal of clinical nutrition.

[17]  Claude Lenfant,et al.  Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[18]  R. Singh,et al.  Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high-risk patients (Indo-Mediterranean diet heart study): a randomized single-blind trial , 2003 .

[19]  Pd redaction.  The prevention or delay of type 2 diabetes. , 2003, Caring : National Association for Home Care magazine.

[20]  F. Kim,et al.  Free Fatty Acid Impairment of Nitric Oxide Production in Endothelial Cells Is Mediated by IKKβ , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[21]  A. Tremblay,et al.  Metabolic impact of body fat distribution , 2002, Journal of endocrinological investigation.

[22]  Roberto Pastor-Barriuso,et al.  Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality , 2005 .

[23]  S. Weisnagel,et al.  Relation of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and fibrinogen to abdominal adipose tissue, blood pressure, and cholesterol and triglyceride levels in healthy postmenopausal women. , 2005, The American journal of cardiology.

[24]  D. Pella,et al.  Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial , 2002, The Lancet.

[25]  J. Manson,et al.  Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. , 2004, The Journal of nutrition.

[26]  G. Paolisso,et al.  Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. , 2002, Journal of the American College of Cardiology.

[27]  E. Mannarino,et al.  Attenuation of inflammation with short-term dietary intervention is associated with a reduction of arterial stiffness in subjects with hypercholesterolaemia , 2004, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[28]  E. Rimm,et al.  Diet, lifestyle, and longevity--the next steps? , 2004, JAMA.

[29]  D. Lau,et al.  Adipokines: molecular links between obesity and atheroslcerosis. , 2005, American journal of physiology. Heart and circulatory physiology.

[30]  Robert M. Anderson,et al.  The prevention or delay of type 2 diabetes. , 2002, Diabetes care.

[31]  S. Homma,et al.  Acute Elevations of Plasma Asymmetric Dimethylarginine and Impaired Endothelial Function in Response to a High-Fat Meal in Patients With Type 2 Diabetes , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[32]  S. Shoelson,et al.  Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB , 2005, Nature Medicine.

[33]  G. Paolisso,et al.  Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus. , 2003, The American journal of clinical nutrition.

[34]  A. Aljada,et al.  The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm , 2002, Diabetologia.

[35]  Mark A Pereira,et al.  Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysis , 2005, The Lancet.

[36]  R. Böger.  Association of Asymmetric Dimethylarginine and Endothelial Dysfunction , 2003, Clinical chemistry and laboratory medicine.

[37]  A. Ceriello,et al.  Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[38]  Y. Terauchi,et al.  The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.

[39]  B. Howard,et al.  Antioxidant Vitamin Supplements and Cardiovascular Disease , 2004, Circulation.

[40]  R. Marfella,et al.  Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects. , 2003, The American journal of clinical nutrition.

[41]  Jianping Ye,et al.  Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. , 2002, The Journal of biological chemistry.

[42]  Tina Costacou,et al.  Adherence to a Mediterranean diet and survival in a Greek population. , 2003, The New England journal of medicine.

[43]  A. Ceriello,et al.  Evidence for an Independent and Cumulative Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Endothelial Dysfunction and Oxidative Stress Generation: Effects of Short- and Long-Term Simvastatin Treatment , 2002, Circulation.

[44]  Nader Rifai,et al.  Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. , 2005, The Journal of nutrition.

[45]  R. Marfella,et al.  Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans: Role of Oxidative Stress , 2002, Circulation.

[46]  M. Andou.  文献紹介[Fast-food habits, weight gain, and insulin resistance (the CARDIA study): 15-year prospective analysis. Pereira, M. A., Kartashov, A. I., Ebbeling, C. B., Horn, L. V., Slattery, M. L., Jacobs Jr., D. R., and Ludwig, D. S. Lancet, 365, 36-42 (2005)] , 2005 .

[47]  Walter C Willett,et al.  Optimal diets for prevention of coronary heart disease. , 2002, JAMA.

[48]  Gösta Samuelson,et al.  Global strategy on diet, physical activity and health , 2004 .

[49]  Jianping Ye,et al.  Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex* 210 , 2002, The Journal of Biological Chemistry.

[50]  E. Rimm,et al.  Habitual Dietary Intake of n-3 and n-6 Fatty Acids in Relation to Inflammatory Markers Among US Men and Women , 2003, Circulation.

[51]  R. Marfella,et al.  Regression of Carotid Atherosclerosis by Control of Postprandial Hyperglycemia in Type 2 Diabetes Mellitus , 2004, Circulation.

[52]  Jean-Louis Martin,et al.  Mediterranean Diet, Traditional Risk Factors, and the Rate of Cardiovascular Complications After Myocardial Infarction Final Report of the Lyon Diet Heart Study , 1999 .

[53]  P. A. Tataranni,et al.  A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes? , 2005, Diabetes.

[54]  R. Kirchmair,et al.  Postprandial state and atherosclerosis , 1995, Current opinion in lipidology.

[55]  H. Lamb,et al.  The association between abdominal visceral fat and carotid stiffness is mediated by circulating inflammatory markers in uncomplicated type 2 diabetes. , 2005, The Journal of clinical endocrinology and metabolism.