The role of airway epithelial cells and innate immune cells in chronic respiratory disease

[1]  Charles M. Rice,et al.  Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response , 2015, Nature.

[2]  M. Castro,et al.  Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. , 2014, The Journal of allergy and clinical immunology.

[3]  C. Akdis,et al.  Th2-type cytokine-induced mucus metaplasia decreases susceptibility of human bronchial epithelium to rhinovirus infection. , 2014, American journal of respiratory cell and molecular biology.

[4]  N. Thomson,et al.  The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. , 2014, American journal of respiratory and critical care medicine.

[5]  W. Busse,et al.  Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. , 2014, The Journal of allergy and clinical immunology.

[6]  L. Boulet,et al.  Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. , 2014, The New England journal of medicine.

[7]  R. Pierce,et al.  Chemosensory functions for pulmonary neuroendocrine cells. , 2014, American journal of respiratory cell and molecular biology.

[8]  P. Openshaw,et al.  Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation⋆ , 2014, The Journal of allergy and clinical immunology.

[9]  K. Austen,et al.  Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. , 2014, Journal of immunology.

[10]  P. Sly,et al.  Defective respiratory tract immune surveillance in asthma: a primary causal factor in disease onset and progression. , 2014, Chest.

[11]  T. Kawayama,et al.  Overexpression of CD163, CD204 and CD206 on Alveolar Macrophages in the Lungs of Patients with Severe Chronic Obstructive Pulmonary Disease , 2014, PloS one.

[12]  S. Johnston,et al.  IL-15 complexes induce NK cell and T cell responses independent of type I IFN signalling during rhinovirus infection , 2014, Mucosal Immunology.

[13]  Z. Ning,et al.  Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity , 2014, Science.

[14]  John F Alcorn,et al.  A tale of two cytokines: IL-17 and IL-22 in asthma and infection , 2014, Expert review of respiratory medicine.

[15]  William C. Nolan,et al.  High-Throughput Screening Normalized to Biological Response , 2014, Journal of biomolecular screening.

[16]  E. Israel,et al.  IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity , 2014 .

[17]  R. Locksley,et al.  Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice , 2013, The Journal of Immunology.

[18]  E. Kerwin,et al.  Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. , 2013, American journal of respiratory and critical care medicine.

[19]  W. Busse,et al.  Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia. , 2013, The Journal of allergy and clinical immunology.

[20]  W. Karpus,et al.  TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica , 2013, Mucosal Immunology.

[21]  A. Barski,et al.  IL-33 Markedly Activates Murine Eosinophils by an NF-κB–Dependent Mechanism Differentially Dependent upon an IL-4–Driven Autoinflammatory Loop , 2013, The Journal of Immunology.

[22]  D. Artis,et al.  Basophils and allergic inflammation. , 2013, The Journal of allergy and clinical immunology.

[23]  I. Sayers,et al.  IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction. , 2013, The Journal of allergy and clinical immunology.

[24]  D. Umetsu,et al.  Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity , 2013, Nature Medicine.

[25]  Ruksha Bhadresha.  Dupilumab in persistent asthma with elevated eosinophil levels , 2013, Thorax.

[26]  R. Locksley,et al.  Type 2 innate lymphoid cells control eosinophil homeostasis , 2013, Nature.

[27]  R. Pierce,et al.  Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. , 2013, The Journal of clinical investigation.

[28]  C. Creighton,et al.  Cleavage of Fibrinogen by Proteinases Elicits Allergic Responses Through Toll-Like Receptor 4 , 2013, Science.

[29]  A. Condliffe,et al.  The neutrophil in chronic obstructive pulmonary disease. , 2013, American journal of respiratory cell and molecular biology.

[30]  R. Locksley,et al.  Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. , 2013, Annual review of immunology.

[31]  R. Locksley,et al.  Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages , 2013, The Journal of experimental medicine.

[32]  E. Israel,et al.  Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma , 2013, Science Translational Medicine.

[33]  Eric Vivier,et al.  Innate lymphoid cells — a proposal for uniform nomenclature , 2013, Nature Reviews Immunology.

[34]  P. Brennan,et al.  Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions , 2013, Nature Reviews Immunology.

[35]  A. McKenzie,et al.  Innate lymphoid cells — how did we miss them? , 2013, Nature Reviews Immunology.

[36]  E. Flaño,et al.  Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells , 2013, Journal of Virology.

[37]  S. Johnston,et al.  Impaired innate interferon induction in severe therapy resistant atopic asthmatic children , 2012, Mucosal Immunology.

[38]  Hsin-Chieh Yeh,et al.  Effect of the 2011 vs 2003 duty hour regulation-compliant models on sleep duration, trainee education, and continuity of patient care among internal medicine house staff: a randomized trial. , 2013, JAMA internal medicine.

[39]  J. Hogg,et al.  Mast cell infiltration discriminates between histopathological phenotypes of chronic obstructive pulmonary disease. , 2012, American journal of respiratory and critical care medicine.

[40]  M. Holtzman,et al.  IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. , 2012, The Journal of clinical investigation.

[41]  A. Vatrella,et al.  The potential of biologics for the treatment of asthma , 2012, Nature Reviews Drug Discovery.

[42]  C. Nichols,et al.  Self-cleavage of Human CLCA1 Protein by a Novel Internal Metalloprotease Domain Controls Calcium-activated Chloride Channel Activation*♦ , 2012, The Journal of Biological Chemistry.

[43]  Vishva M Dixit,et al.  Inflammasomes and their roles in health and disease. , 2012, Annual review of cell and developmental biology.

[44]  Ian D Pavord,et al.  Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial , 2012, The Lancet.

[45]  Deborah A Meyers,et al.  IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist. , 2012, The Journal of allergy and clinical immunology.

[46]  M. Holtzman.  Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens. , 2012, The Journal of clinical investigation.

[47]  H. Hammad,et al.  Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33 , 2012, The Journal of experimental medicine.

[48]  Christopher E Brightling,et al.  Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. , 2012, American journal of respiratory and critical care medicine.

[49]  C. Brightling,et al.  A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma , 2012, European Respiratory Journal.

[50]  William C. Nolan,et al.  High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery , 2012, PloS one.

[51]  S. Holgate.  Trials and tribulations in identifying new biologic treatments for asthma. , 2012, Trends in immunology.

[52]  Stephen J Galli,et al.  IgE and mast cells in allergic disease , 2012, Nature Medicine.

[53]  K. Kubo,et al.  Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma , 2012, International journal of chronic obstructive pulmonary disease.

[54]  A. Kraneveld,et al.  Dual Role of Toll-Like Receptors in Asthma and Chronic Obstructive Pulmonary Disease , 2012, Pharmacological Reviews.

[55]  Hergen Spits,et al.  Innate lymphoid cells: emerging insights in development, lineage relationships, and function. , 2012, Annual review of immunology.

[56]  X. Hua,et al.  Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice , 2012, The Journal of Immunology.

[57]  O. Ramilo,et al.  Plasticity and Virus Specificity of the Airway Epithelial Cell Immune Response during Respiratory Virus Infection , 2012, Journal of Virology.

[58]  H. Kita,et al.  IL-33–Responsive Lineage−CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs , 2012, The Journal of Immunology.

[59]  D. Sheppard,et al.  IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction , 2012, Nature Medicine.

[60]  B. Monsarrat,et al.  IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G , 2012, Proceedings of the National Academy of Sciences.

[61]  N. Thomson,et al.  Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. , 2012, The Journal of allergy and clinical immunology.

[62]  He Li,et al.  Retraction: Vα24-Invariant NKT Cells from Patients with Allergic Asthma Express CCR9 at High Frequency and Induce Th2 Bias of CD3+ T Cells upon CD226 Engagement , 2005, The Journal of Immunology.

[63]  A. McKenzie,et al.  Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. , 2012, The Journal of allergy and clinical immunology.

[64]  Jiaquan Xu,et al.  Deaths: final data for 2009. , 2011, National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System.

[65]  J. Corren.  Anti-interleukin-5 antibody therapy in asthma and allerges , 2011, Current opinion in allergy and clinical immunology.

[66]  L. Boulet,et al.  Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. , 2011, American journal of respiratory and critical care medicine.

[67]  Hergen Spits,et al.  Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 , 2011, Nature Immunology.

[68]  David Artis,et al.  Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus , 2011, Nature Immunology.

[69]  Yusuke Yamamoto,et al.  Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection , 2011, Cell.

[70]  Nicola A Hanania,et al.  Lebrikizumab treatment in adults with asthma. , 2011, The New England journal of medicine.

[71]  H. Tsutsumi,et al.  Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells. , 2011, Virus research.

[72]  Takaya Suzuki,et al.  Evidence for human lung stem cells. , 2011, The New England journal of medicine.

[73]  Ya-Jen Chang,et al.  Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity , 2011, Nature Immunology.

[74]  Arnoud Sonnenberg,et al.  Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice. , 2011, The Journal of clinical investigation.

[75]  Ryan D. Hernandez,et al.  Meta-analysis of Genome-wide Association Studies of Asthma In Ethnically Diverse North American Populations , 2011, Nature Genetics.

[76]  J. McQualter,et al.  Functional analysis of two distinct bronchiolar progenitors during lung injury and repair. , 2011, American journal of respiratory cell and molecular biology.

[77]  P. Howarth,et al.  Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus. , 2011, The Journal of allergy and clinical immunology.

[78]  David J. Miller,et al.  MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness , 2011, PLoS pathogens.

[79]  The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses , 2011, The Journal of Immunology.

[80]  P. Gergen,et al.  Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. , 2011, The New England journal of medicine.

[81]  S. Johnston,et al.  Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation. , 2011, American journal of respiratory and critical care medicine.

[82]  W. Busse,et al.  Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. , 2011, American journal of respiratory and critical care medicine.

[83]  E. Richer,et al.  Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response , 2011, Virulence.

[84]  A. Stipić-Marković,et al.  Viruses and bacteria in acute asthma exacerbations – A GA2LEN‐DARE* systematic review , 2010, Allergy.

[85]  H. Boushey,et al.  Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection. , 2010, American journal of respiratory cell and molecular biology.

[86]  M. Holtzman,et al.  Cutting Edge: CD49d+ Neutrophils Induce FcεRI Expression on Lung Dendritic Cells in a Mouse Model of Postviral Asthma , 2010, The Journal of Immunology.

[87]  Florence Demenais,et al.  A large-scale, consortium-based genomewide association study of asthma. , 2010, The New England journal of medicine.

[88]  S. Paludan,et al.  Mechanisms of type III interferon expression. , 2010, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[89]  G. Núñez,et al.  Respiratory Virus-Induced TLR7 Activation Controls IL-17–Associated Increased Mucus via IL-23 Regulation , 2010, The Journal of Immunology.

[90]  Jennifer R. Clark,et al.  Complement-mediated regulation of the interleukin 17A axis is a central genetic determinant of the severity of experimental allergic asthma , 2010, Nature Immunology.

[91]  J. Curtis,et al.  Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease. , 2010, American journal of respiratory and critical care medicine.

[92]  M. Holtzman,et al.  Alternatively activated macrophages as cause or effect in airway disease. , 2010, American journal of respiratory cell and molecular biology.

[93]  David J. Erle,et al.  Systemically dispersed innate IL-13–expressing cells in type 2 immunity , 2010, Proceedings of the National Academy of Sciences.

[94]  C. Mackay,et al.  MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. , 2010, The Journal of allergy and clinical immunology.

[95]  S. Gordon,et al.  Alternative activation of macrophages: mechanism and functions. , 2010, Immunity.

[96]  M. Wills-Karp,et al.  Complement-mediated Regulation Of The IL-17A Axis Is A Central Genetic Determinant Of The Severity Of Experimental Allergic Asthma , 2010, ATS 2010.

[97]  F. Di Virgilio,et al.  Extracellular adenosine triphosphate and chronic obstructive pulmonary disease. , 2010, American journal of respiratory and critical care medicine.

[98]  W. Busse,et al.  A review of treatment with mepolizumab, an anti-IL-5 mAb, in hypereosinophilic syndromes and asthma. , 2010, The Journal of allergy and clinical immunology.

[99]  R. Kastelein,et al.  IL-25 elicits a multi-potent progenitor cell population that promotes Th2 cytokine responses , 2010, Nature.

[100]  A. McKenzie,et al.  Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity , 2010, Nature.

[101]  J. Alcorn,et al.  TH17 cells in asthma and COPD. , 2010, Annual review of physiology.

[102]  J. McQualter,et al.  Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung , 2010, Proceedings of the National Academy of Sciences.

[103]  Michael J. Holtzman,et al.  Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo , 2010, PLoS pathogens.

[104]  S. Willsie.  Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma , 2010 .

[105]  S. Keleş,et al.  Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma , 2010, Mucosal Immunology.

[106]  Tsutomu Takeuchi,et al.  Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells , 2009, Nature.

[107]  Parameswaran Nair,et al.  Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. , 2009, The New England journal of medicine.

[108]  P. Weller,et al.  Functional extracellular eosinophil granules: novel implications in eosinophil immunobiology. , 2009, Current opinion in immunology.

[109]  D. Altmann,et al.  Natural killer T cells in bronchial biopsies from human allergen challenge model of allergic asthma. , 2009, The Journal of allergy and clinical immunology.

[110]  R. Pierce,et al.  Macrophage chitinase 1 stratifies chronic obstructive lung disease. , 2009, American journal of respiratory cell and molecular biology.

[111]  Scott H. Randell,et al.  Basal cells as stem cells of the mouse trachea and human airway epithelium , 2009, Proceedings of the National Academy of Sciences.

[112]  W. Busse,et al.  Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16. , 2009, The Journal of allergy and clinical immunology.

[113]  G. Barton,et al.  A cell biological view of Toll-like receptor function: regulation through compartmentalization , 2009, Nature Reviews Immunology.

[114]  Fan Wang,et al.  The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. , 2009, Cell stem cell.

[115]  H. Boushey,et al.  In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects. , 2009, The Journal of allergy and clinical immunology.

[116]  E. Israel,et al.  Natural killer T cells in the lungs of patients with asthma. , 2009, The Journal of allergy and clinical immunology.

[117]  R. Webby,et al.  The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. , 2009, Immunity.

[118]  J. Ting,et al.  The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. , 2009, Immunity.

[119]  M. Holtzman,et al.  A Distinct Population of Non-B, Non-T (NBNT) Cells Express High Levels of IL-13 during Acute and Chronic Airway Disease after Viral Infection. , 2009, ATS 2009.

[120]  Akiko Iwasaki,et al.  Inflammasome recognition of influenza virus is essential for adaptive immune responses , 2009, The Journal of experimental medicine.

[121]  R. Hegde,et al.  Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein , 2008, Nature.

[122]  S. Johnston,et al.  Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production , 2008, Proceedings of the National Academy of Sciences.

[123]  J. Ceuppens,et al.  Type III IFN‐λ mRNA expression in sputum of adult and school‐aged asthmatics , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[124]  Jeffrey D. Morton,et al.  Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease , 2008, Nature Medicine.

[125]  J. Tschopp,et al.  The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response , 2008, Nature.

[126]  M. Holtzman,et al.  Airway Epithelial versus Immune Cell Stat1 Function for Innate Defense against Respiratory Viral Infection1 , 2008, The Journal of Immunology.

[127]  T. Michiels,et al.  IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo , 2008, PLoS pathogens.

[128]  J. Curtis,et al.  TLR3 Increases Disease Morbidity and Mortality from Vaccinia Infection1 , 2008, The Journal of Immunology.

[129]  S. Akira,et al.  IL‐33 induces IL‐13 production by mouse mast cells independently of IgE‐FcεRI signals , 2007 .

[130]  M. Holtzman,et al.  Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia , 2007, The Journal of experimental medicine.

[131]  P. Sly,et al.  Th2 cytokines in the asthma late-phase response , 2007, The Lancet.

[132]  S. Wenzel,et al.  Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies , 2007, The Lancet.

[133]  Yee Hwa Yang,et al.  Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids , 2007, Proceedings of the National Academy of Sciences.

[134]  S. Kotenko,et al.  IFN Regulatory Factor Family Members Differentially Regulate the Expression of Type III IFN (IFN-λ) Genes1 , 2007, The Journal of Immunology.

[135]  P. Avila,et al.  TLR3- and Th2 Cytokine-Dependent Production of Thymic Stromal Lymphopoietin in Human Airway Epithelial Cells1 , 2007, The Journal of Immunology.

[136]  G. Berry,et al.  Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. , 2007, Blood.

[137]  R. Djukanović,et al.  Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease. , 2007, The New England journal of medicine.

[138]  Yusuke Nakamura,et al.  Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. , 2007, American journal of respiratory cell and molecular biology.

[139]  J. Bousquet,et al.  Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach. , 2007 .

[140]  L. Kaer,et al.  Natural killer T cells and CD8+ T cells are dispensable for T cell–dependent allergic airway inflammation , 2006, Nature Medicine.

[141]  R. Flavell,et al.  TLR3 Deletion Limits Mortality and Disease Severity due to Phlebovirus Infection1 , 2006, The Journal of Immunology.

[142]  Stephen T Holgate,et al.  Role of deficient type III interferon-λ production in asthma exacerbations , 2006, Nature Medicine.

[143]  S. Brody,et al.  Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells , 2006, Journal of Virology.

[144]  Lena Alexopoulou,et al.  Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia , 2006, PLoS pathogens.

[145]  Richard A Flavell,et al.  Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[146]  Jeffrey D. Morton,et al.  Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members. , 2006, Physiological genomics.

[147]  K. Ishii,et al.  Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses , 2006, Nature.

[148]  Niamh E Mangan,et al.  Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion , 2006, The Journal of experimental medicine.

[149]  G. Berry,et al.  CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. , 2006, The New England journal of medicine.

[150]  A. Gruber,et al.  Deletion of TLR3 Alters the Pulmonary Immune Environment and Mucus Production during Respiratory Syncytial Virus Infection , 2006, The Journal of Immunology.

[151]  Ralf Bartenschlager,et al.  Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus , 2005, Nature.

[152]  He Li,et al.  Vα24-Invariant NKT Cells from Patients with Allergic Asthma Express CCR9 at High Frequency and Induce Th2 Bias of CD3+ T Cells upon CD226 Engagement1 , 2005, The Journal of Immunology.

[153]  M. Holtzman,et al.  Modification of the Stat1 SH2 Domain Broadly Improves Interferon Efficacy in Proportion to p300/CREB-binding Protein Coactivator Recruitment*♦ , 2005, Journal of Biological Chemistry.

[154]  S. Johnston,et al.  Toll-Like Receptor 3 Is Induced by and Mediates Antiviral Activity against Rhinovirus Infection of Human Bronchial Epithelial Cells , 2005, Journal of Virology.

[155]  Z. Zhai,et al.  VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling , 2005 .

[156]  Zhijian J. Chen,et al.  Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 , 2005, Cell.

[157]  S. Johnston,et al.  Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus , 2005, The Journal of experimental medicine.

[158]  S. Akira,et al.  Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus* , 2005, Journal of Biological Chemistry.

[159]  Zhijian J. Chen,et al.  Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. , 2005, Cell.

[160]  E. Fikrig,et al.  Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis , 2004, Nature Medicine.

[161]  B. Stripp,et al.  Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. , 2004, American journal of respiratory cell and molecular biology.

[162]  Shizuo Akira,et al.  The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses , 2004, Nature Immunology.

[163]  P. Paré,et al.  The nature of small-airway obstruction in chronic obstructive pulmonary disease. , 2004, The New England journal of medicine.

[164]  K. Ley,et al.  Trafficking of natural killer cells. , 2004, Current molecular medicine.

[165]  Shizuo Akira,et al.  Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA , 2004, Science.

[166]  S. Akira,et al.  Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 , 2004, Science.

[167]  Abdulmajeed Al Abdukareem.  Randomized, placebo-controlled trial , 2004, Annals of Saudi medicine.

[168]  Jaynelle F Stichler,et al.  A comprehensive approach. , 2004, Marketing health services.

[169]  P. van Endert,et al.  Cutting Edge: Invariant Vα14 NKT Cells Are Required for Allergen-Induced Airway Inflammation and Hyperreactivity in an Experimental Asthma Model1 , 2003, The Journal of Immunology.

[170]  P. Paré,et al.  Characterization of airway plugging in fatal asthma. , 2003, The American journal of medicine.

[171]  B. Williams,et al.  Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis. , 2003, Immunity.

[172]  D. Umetsu,et al.  Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity , 2003, Nature Medicine.

[173]  P. Hellings,et al.  Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. , 2003, American journal of respiratory cell and molecular biology.

[174]  Toshiaki Kawakami,et al.  Regulation of mast-cell and basophil function and survival by IgE , 2002, Nature Reviews Immunology.

[175]  Jeffrey D. Morton,et al.  Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. , 2002, The Journal of clinical investigation.

[176]  Epithelial-mesenchymal interactions in the pathogenesis of asthma. , 2011, The Journal of allergy and clinical immunology.

[177]  S. Akira,et al.  A Toll-like receptor recognizes bacterial DNA , 2000, Nature.

[178]  D. Sampath,et al.  Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. , 1999, The Journal of clinical investigation.

[179]  D. Sampath,et al.  Control of epithelial immune-response genes and implications for airway immunity and inflammation. , 1998, Proceedings of the Association of American Physicians.

[180]  H. Dargie,et al.  A multicentre, double-blind, placebo-controlled trial of quinapril in mild, chronic heart failure. , 1993, European heart journal.

[181]  Holtzman Mj,et al.  Experimental airway inflammation and hyperreactivity. Searching for cells and mediators. , 1985 .

[182]  P. O'Byrne,et al.  Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure. , 1984, The American review of respiratory disease.

[183]  P. O'Byrne,et al.  Importance of airway inflammation for hyperresponsiveness induced by ozone. , 1983, The American review of respiratory disease.