AKR1B10: A New Diagnostic Marker of Non–Small Cell Lung Carcinoma in Smokers

Lung cancer is a leading cause of cancer death worldwide, and non–small cell lung carcinoma (NSCLC) accounts for 80% of the cases. Even the most innovative therapeutic regimens do not increase overall 5-year survival rates for NSCLC to >15%. Early detection methods could lead to intervention

[1]  N. Palackal,et al.  Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones. , 1999, Chemical research in toxicology.

[2]  K. Itoh,et al.  An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. , 1997, Biochemical and biophysical research communications.

[3]  T. Penning,et al.  Aldo-keto reductases and toxicant metabolism , 2003 .

[4]  Michael E. Burczynski,et al.  Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones , 2000 .

[5]  D. V. Vander Jagt,et al.  Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications. , 2001, Chemico-biological interactions.

[6]  Michael Karin,et al.  Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors , 1996, Science.

[7]  K. Chow,et al.  Increased Expression of Dihydrodiol Dehydrogenase Induces Resistance to Cisplatin in Human Ovarian Carcinoma Cells* , 2002, The Journal of Biological Chemistry.

[8]  K. Tew,et al.  cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase. , 1994, Biochimica et biophysica acta.

[9]  T. Flynn,et al.  Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism. , 2003, The Biochemical journal.

[10]  Tzei-Yi Lin,et al.  Overexpression of dihydrodiol dehydrogenase as a prognostic marker of non-small cell lung cancer. , 2001, Cancer research.

[11]  Sheung Tat Fan,et al.  Identification and Characterization of a Novel Human Aldose Reductase-like Gene* , 1998, The Journal of Biological Chemistry.

[12]  K. Tew,et al.  Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. , 1994, The Journal of biological chemistry.

[13]  F. Khuri,et al.  Retinoids in lung cancer: friend, foe, or fellow traveler? , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  R. Hayden,et al.  The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs. , 2003, Cancer research.

[15]  T. Penning,et al.  Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action. , 2003, Human reproduction update.

[16]  T. Penning,et al.  The aldo-keto reductase superfamily homepage. , 2003, Chemico-biological interactions.

[17]  T. Flynn,et al.  Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family. , 1998, Biochimica et biophysica acta.

[18]  A. Hölscher,et al.  Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis. , 2004, Carcinogenesis.

[19]  N. Palackal,et al.  Activation of Polycyclic Aromatic Hydrocarbontrans-Dihydrodiol Proximate Carcinogens by Human Aldo-keto Reductase (AKR1C) Enzymes and Their Functional Overexpression in Human Lung Carcinoma (A549) Cells* , 2002, The Journal of Biological Chemistry.

[20]  J. von Lintig,et al.  Filling the Gap in Vitamin A Research , 2000, The Journal of Biological Chemistry.

[21]  T. Penning,et al.  Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. , 1999, Cancer research.

[22]  K. Bohren,et al.  Osmotic Response Element Enhancer Activity , 1999, The Journal of Biological Chemistry.