Theoretical insights into the origin of signal-induced calcium oscillations

Publisher Summary This chapter discusses the origin of signal-induced calcium oscillations. In a variety of cells, stimulation by an external signal triggers a train of intracellular calcium spikes. The steady-state concentration of sequestered calcium can readily be obtained by setting the resulting algebraic equation equal to zero. A physically acceptable steady state will exist as long as the maximum release rate is sufficiently larger than the maximum pumping rate. The waveform of the oscillations predicted by the model for cytosolic calcium resembles that of the spikes observed for a number of cells stimulated by external signals. In particular, the rise in cytosolic calcium is preceded by a rapid acceleration that starts from the basal level. This pattern, which is reminiscent of the pacemaker potential that triggers autonomous spiking in nerve and muscle cells, has been observed in epithelial cells stimulated by histamine. The oscillations of calcium in the intracellular store have a sawtooth appearance.

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