Signal transmission between the plasma membrane and nucleus of T lymphocytes.

INITIATING THE GENETIC PROGRAM LEADING TO T CELL ACTIVATION 1057 Integration of the Diverse Signals Required for T Cell Activation on the Regulatory Regions of Early Genes ..... .. . .. . .. . . ... . 1057 The NF-AT Transcriptional Complex . . . . . . . . . . . . . . . . . . . . . . . . . . .. 1058 An Association Between JUIl D and Octl Appears to Play an Important Role ill Activating the IL-2 Gene ....... . .... .... ..... . .. . . 1062 The Roles of NF-Kl3 and AP-l in T Cell Activation . . . . . ... . . . .. .. . . . 1063 CALCINEURIN: AN ESSENTIAL SIGNALLING INTERMEDIATE ......... 1064 Calcineurin in Other Cells and Species .. . ...... . .. . 1069 Is Calcineurin a Rate-Limiting Step in T Cell Activation? 1070