Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant.

We utilize the supramolecular self-assembling peptide of Nap-GDFDFDYDK to construct chemically programmed, self-assembling and self-adjuvant MUC1-based antitumor vaccines. The vaccines, with antigen and adjuvant conjugation through covalent bonds, elicited both humoral and cellular immune responses.

[1]  D. Ding,et al.  Enzymatic induction of supramolecular order and bioactivity. , 2016, Nanoscale.

[2]  Yonggang Yang,et al.  Peptide Glycosylation Generates Supramolecular Assemblies from Glycopeptides as Biomimetic Scaffolds for Cell Adhesion and Proliferation. , 2016, ACS applied materials & interfaces.

[3]  Changyang Gong,et al.  Enzyme‐Catalyzed Formation of Supramolecular Hydrogels as Promising Vaccine Adjuvants , 2016 .

[4]  Yiming Shao,et al.  In situ formation of peptidic nanofibers can fundamentally optimize the quality of immune responses against HIV vaccine. , 2016, Nanoscale horizons.

[5]  Jie Zhou,et al.  Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials , 2015, Chemical reviews.

[6]  Job Boekhoven,et al.  Transient assembly of active materials fueled by a chemical reaction , 2015, Science.

[7]  Huaimin Wang,et al.  Supramolecular nanofibers of self-assembling peptides and proteins for protein delivery. , 2015, Chemical communications.

[8]  Bing Xu,et al.  Supramolecular Glycosylation Accelerates Proteolytic Degradation of Peptide Nanofibrils , 2015, Journal of the American Chemical Society.

[9]  Xuefei Huang,et al.  Lipopeptide-Coated Iron Oxide Nanoparticles as Potential Glycoconjugate-Based Synthetic Anticancer Vaccines. , 2015, ACS applied materials & interfaces.

[10]  R. Zentel,et al.  CpG‐Loaded Multifunctional Cationic Nanohydrogel Particles as Self‐Adjuvanting Glycopeptide Antitumor Vaccines , 2015, Advanced healthcare materials.

[11]  Yong-Xiang Chen,et al.  Covalent bond or noncovalent bond: a supramolecular strategy for the construction of chemically synthesized vaccines. , 2014, Chemistry.

[12]  R. Gonnade,et al.  Multicomponent reactions involving phosphines, arynes and aldehydes. , 2014, Chemical communications.

[13]  Joel H. Collier,et al.  Gradated assembly of multiple proteins into supramolecular nanomaterials , 2014, Nature materials.

[14]  Wei Zhang,et al.  A peptide-based nanofibrous hydrogel as a promising DNA nanovector for optimizing the efficacy of HIV vaccine. , 2014, Nano letters.

[15]  R. Zentel,et al.  Water-soluble polymers coupled with glycopeptide antigens and T-cell epitopes as potential antitumor vaccines. , 2013, Angewandte Chemie.

[16]  Neil R. Cameron,et al.  ‘Multicopy Multivalent’ Glycopolymer-Stabilized Gold Nanoparticles as Potential Synthetic Cancer Vaccines , 2013, Journal of the American Chemical Society.

[17]  Yan‐Mei Li,et al.  Self-adjuvanting synthetic antitumor vaccines from MUC1 glycopeptides conjugated to T-cell epitopes from tetanus toxoid. , 2013, Angewandte Chemie.

[18]  H. Kunz,et al.  The development of synthetic antitumour vaccines from mucin glycopeptide antigens. , 2013, Chemical Society reviews.

[19]  Jing-Wen Ma,et al.  A totally synthetic, self-assembling, adjuvant-free MUC1 glycopeptide vaccine for cancer therapy. , 2012, Journal of the American Chemical Society.

[20]  E. W. Meijer,et al.  Functional Supramolecular Polymers , 2012, Science.

[21]  Yan‐Mei Li,et al.  Variation of the glycosylation pattern in MUC1 glycopeptide BSA vaccines and its influence on the immune response. , 2012, Angewandte Chemie.

[22]  Jangwook P. Jung,et al.  A self-assembling peptide acting as an immune adjuvant , 2009, Proceedings of the National Academy of Sciences.

[23]  E. Schmitt,et al.  A synthetic vaccine consisting of a tumor-associated sialyl-T(N)-MUC1 tandem-repeat glycopeptide and tetanus toxoid: induction of a strong and highly selective immune response. , 2009, Angewandte Chemie.

[24]  R. Das,et al.  Supramolecular gels ‘in action’ , 2009 .

[25]  Margarida Saraiva,et al.  Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose , 2009, Immunity.

[26]  Zhang Shuguang,et al.  Designer self-assembling peptide nanomaterials , 2009 .

[27]  W. Paul,et al.  CD4 T cells: fates, functions, and faults. , 2008, Blood.

[28]  Andrew M. Smith,et al.  Designing peptide based nanomaterials. , 2008, Chemical Society reviews.

[29]  M. Wolfert,et al.  Robust immune responses elicited by a fully synthetic three-component vaccine. , 2007, Nature chemical biology.

[30]  Jeffery T. Davis,et al.  Supramolecular architectures generated by self-assembly of guanosine derivatives. , 2007, Chemical Society reviews.

[31]  P. Vemula,et al.  Enzyme catalysis: tool to make and break amygdalin hydrogelators from renewable resources: a delivery model for hydrophobic drugs. , 2006, Journal of the American Chemical Society.

[32]  H. Scher,et al.  Thomsen-Friedenreich (TF) antigen as a target for prostate cancer vaccine: clinical trial results with TF cluster (c)-KLH plus QS21 conjugate vaccine in patients with biochemically relapsed prostate cancer , 2005, Cancer Immunology, Immunotherapy.

[33]  Krista L. Niece,et al.  Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers , 2004, Science.

[34]  B. Longenecker,et al.  Mucin 1-Specific Immunotherapy in a Mouse Model of Spontaneous Breast Cancer , 2003, Journal of immunotherapy.

[35]  H. Kunz,et al.  Solid‐Phase Synthesis of a Tumor‐Associated Sialyl‐TN Antigen Glycopeptide with a Partial Sequence of the “Tandem Repeat” of the MUC‐1 Mucin , 1997 .

[36]  T. Toyokuni,et al.  Synthetic carbohydrate vaccines based on tumour-associated antigens , 1996 .

[37]  J. Kihlberg,et al.  Removal of Acyl Protective Groups from Glycopeptides: Base Does Not Epimerize Peptide Stereocenters, and beta-Elimination Is Slow. , 1996, The Journal of organic chemistry.

[38]  W. Paul,et al.  Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. , 1987, Science.

[39]  W. Hager,et al.  and s , 2019, Shallow Water Hydraulics.

[40]  W. Marsden I and J , 2012 .