Glucose‐sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea‐pig.

1. Afferent discharges were recorded from nerve filaments dissected from the hepatic branch of the vagus nerve in the guinea‐pig in situ. 2. A significant decrease in the discharge rate was observed following the administration of D‐glucose into the portal vein but not after the administration of D‐mannose, D‐fructose, D‐galactose, L‐glucose, D‐xylose or D‐arabinose. 3. The mean discharge rate of these fibres was inversely related to the concentration of glucose in the portal blood. 4. These results suggest the existence of D‐glucose ‘sensors’ in the liver which monitor the glucose concentration of portal blood.

[1]  J. Louis-Sylvestre.  Hepatic glucoreceptors do exist but do not control food intake , 1981, Appetite.

[2]  L. Bellinger.  Commentary on “the current status of the hepatostatic theory of food intake control” , 1981, Appetite.

[3]  M. Russek.  Current status of the hepatostatic theory of food intake control , 1981, Appetite.

[4]  A. Niijima.  Glucose sensitive afferent nerve fibers in the liver and regulation of blood glucose , 1980, Brain Research Bulletin.

[5]  J. Louis-Sylvestre,et al.  Effect of liver denervation on the feeding pattern of rats. , 1980, The American journal of physiology.

[6]  K. Yamaguchi,et al.  Effects of electrical stimulation of the hepatic vagus nerve on the plasma insulin concentration in the rat , 1979, Brain Research.

[7]  N. Mei.  Vagal glucoreceptors in the small intestine of the cat. , 1978, The Journal of physiology.

[8]  J. R. Henderson,et al.  The effect of atropine on the insulin release caused by oral and intravenous glucose in human subjects. , 1976, Acta endocrinologica.

[9]  H. L. Jacobs,et al.  An hepatic osmoreceptor mechanism in the rat: electrophysiological and behavioral studies. , 1976, The American journal of physiology.

[10]  F. Bell,et al.  The influence of gastric distension and the duodenal infusate on the pattern of stomach (abomasal) emptying in the preruminant calf. , 1976, The Journal of physiology.

[11]  M. Cabanac.  Physiological Role of Pleasure , 1971, Science.

[12]  A. Niijima,et al.  Afferent Discharges from Osmoreceptors in the Liver of the Guinea Pig , 1969, Science.

[13]  K. N. Sharma,et al.  Electrical activity in mesenteric nerves after perfusion of gut lumen. , 1962, The American journal of physiology.

[14]  T. Sakaguchi,et al.  Reflex secretion of insulin evoked by hepatic portal injection of D-glucose anomers in the rat , 1981 .

[15]  C. Rozé,et al.  Inhibition of gastric electrical and mechanical activity by intraduodenal agents in pigs and the effects of vagotomy. , 1977, Digestion.

[16]  M. Cabanac,et al.  Alliesthésie olfacto-gustative et prise alimentaire chez l'homme. , 1973 .

[17]  B. Leek.  Abdominal Visceral Receptors , 1972 .