Adrenal steroid responses to ACTH in glucocorticoid-suppressible aldosteronism.

To investigate adrenal responses to adrenocorticotrophin (ACTH), we infused graded doses of ACTH (1.25 to 20.0 mIU/30 minutes) in normal subjects, patients with low-renin essential hypertension (LREH), primary aldosteronism (PA), and glucocorticoid-suppressible hyperaldosteronism (GSH). Plasma aldosterone, cortisol, corticosterone, and 18-hydroxycorticosterone were measured. The results revealed a greater increase in the plasma aldosterone and 18-hydroxycorticosterone levels evoked by ACTH in the GSH group than in any other group, which suggested enhanced responsiveness of the aldosterone-producing cells to ACTH and a probable adrenal abnormality.

[1]  N. Fineberg,et al.  Differing effects of metoclopramide and adrenocorticotropin on plasma aldosterone levels in glucocorticoid-suppressible hyperaldosteronism and other forms of hyperaldosteronism. , 1983, The Journal of clinical endocrinology and metabolism.

[2]  M. Land,et al.  Biosynthesis of 18-oxocortisol by aldosterone-producing adrenal tissue. , 1983, The Journal of biological chemistry.

[3]  J. Gill,et al.  Plasma immunoreactive proopiolipomelanocortin-derived peptides in patients with primary hyperaldosteronism, idiopathic hyperaldosteronism with bilateral adrenal hyperplasia, and dexamethasone-suppressible hyperaldosteronism. , 1983, The Journal of clinical endocrinology and metabolism.

[4]  S. Textor,et al.  The changing clinical spectrum of primary aldosteronism. , 1983, The American journal of medicine.

[5]  J. Donohue,et al.  Primary Aldosteronism: Pathophysiology, Diagnosis and Treatment , 1983 .

[6]  A. Ganguly.  New insights and questions about glucocorticoid-suppressible hyperaldosteronism. , 1982, The American journal of medicine.

[7]  S. Ulick,et al.  Isolation and identification of 18-hydroxycortisol from the urine of patients with primary aldosteronism. , 1982, The Journal of biological chemistry.

[8]  T. Benraad,et al.  Direct radioimmunoassays for "aldosterone" and "18-hydroxycorticosterone" in unprocessed urine, and their use in screening to distinguish primary aldosteronism from hypertension. , 1982, Clinical chemistry.

[9]  S. Ulick,et al.  Hypersecretion of a new corticosteroid, 18-hydroxycortisol in two types of adrenocortical hypertension. , 1982, Clinical and experimental hypertension. Part A, Theory and practice.

[10]  M. Weinberger,et al.  Primary aldosteronism: effects of inhibition of ACTH and potassium administration on plasma aldosterone concentration. , 1982, Clinical and experimental hypertension. Part A, Theory and practice.

[11]  M. Weinberger,et al.  Genetic and pathophysiologic studies of a new kindred with glucocorticoid-suppressible hyperaldosteronism manifest in three generations. , 1981, The Journal of clinical endocrinology and metabolism.

[12]  P. Mulrow.  Glucocorticoid-suppressible hyperaldosteronism: a clue to the missing hormone? , 1981, The New England journal of medicine.

[13]  M. Weinberger,et al.  Anomalous postural aldosterone response in glucocorticoid-suppressible hyperaldosteronism. , 1981, The New England journal of medicine.

[14]  G. Guthrie.  Multiple plasma steroid responses to graded ACTH infusions in patients with primary aldosteronism. , 1981, The Journal of laboratory and clinical medicine.

[15]  M. Weinberger,et al.  Triamterene‐thiazide combination: Alternative therapy for primary aldosteronism , 1981, Clinical pharmacology and therapeutics.

[16]  J. Gill,et al.  Overproduction of sodium-retaining steroids by the zona glomerulosa is adrenocorticotropin-dependent and mediates hypertension in dexamethasone-suppressible aldosteronism. , 1981, The Journal of clinical endocrinology and metabolism.

[17]  T. Usa,et al.  Differences between adrenal adenoma causing primary aldosteronism and other adrenal tissues in the incorporation of labeled steroid precursors into their products , 1980, Steroids.

[18]  M. Weinberger,et al.  Familial, dexamethasone-suppressible, normokalemic hyperaldosteronism. , 1980, Pediatrics.

[19]  M. Schambelan,et al.  The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism. , 1979, The Journal of clinical endocrinology and metabolism.

[20]  M. Weinberger,et al.  Primary aldosteronism: diagnosis, localization, and treatment. , 1979, Annals of internal medicine.

[21]  G. Williams,et al.  Effects of dietary sodium and potassium intake and acute stimulation on aldosterone output by isolated human adrenal cells. , 1977, The Journal of clinical endocrinology and metabolism.

[22]  M. Chavarri,et al.  Transient fall and subsequent return of high aldosterone secretion by adrenal adenoma during continued dexamethasone administration. , 1977, The Journal of clinical endocrinology and metabolism.

[23]  M. Weinberger,et al.  Diagnosis of secondary forms of hypertension. A comprehensive protocol. , 1977, JAMA.

[24]  R. E. Peterson,et al.  Evidence for an unidentified ACTH-induced steroid hormone causing hypertension. , 1976, The Journal of clinical endocrinology and metabolism.

[25]  C. Lantos,et al.  Comparative biosynthetic studies in a case of primary aldosteronism. , 1976, Journal of steroid biochemistry.

[26]  M. Schambelan,et al.  Circadian rhythm and effect of posture on plasma aldosterone concentration in primary aldosteronism. , 1976, The Journal of clinical endocrinology and metabolism.

[27]  F. Katz,et al.  Diurnal variation of plasma aldosterone, cortisol and renin activity in supine man. , 1975, The Journal of clinical endocrinology and metabolism.

[28]  R. E. Peterson,et al.  Dexamethasone-suppressible hyperaldosteronism. , 1973, The Journal of clinical endocrinology and metabolism.

[29]  F. Katz,et al.  A kindred with familial glucocorticoid suppressible aldosteronism. , 1973, The Journal of clinical endocrinology and metabolism.

[30]  C. Gomez-Sanchez,et al.  A radioimmunoassay for plasma aldosterone by immunologic purification. , 1973, The Journal of clinical endocrinology and metabolism.

[31]  M. Weinberger,et al.  Effect of chlorothiazide and sodium on vascular responsiveness to angiotensin II. , 1972, The American journal of physiology.

[32]  O. J. Lucis,et al.  Comparison of steroidogenesis in adrenal tissue and adrenal adenoma from a case of primary aldosteronism , 1971 .

[33]  J. Palmer,et al.  18-hydroxylation by human adrenal tissue in vitro. , 1970, The Journal of clinical endocrinology and metabolism.

[34]  H. Wolff,et al.  Studies on the biosynthesis of aldosterone in solitary adenoma and in nodular hyperplasia of the adrenal cortex in patients exhibiting Conn's syndrome. , 1969, Acta endocrinologica.

[35]  E. Biglieri,et al.  Effect of adrenocorticotropin on desoxycorticosterone, corticosterone and aldosterone excretion. , 1969, The Journal of clinical endocrinology and metabolism.

[36]  I. Salti,et al.  Non-tumorous "primary" aldosteronism. I. Type relieved by glucocorticoid (glucocorticoid-remediable aldosteronism). , 1969, Canadian Medical Association journal.

[37]  I. Salti,et al.  Non-tumorous "primary" aldosteronism: II. Type not relieved by glucocorticoid. , 1969, Canadian Medical Association journal.

[38]  K. Yoshinaga,et al.  A case of glucocorticoid-responsive hyperaldosteronism. , 1968, The Journal of clinical endocrinology and metabolism.

[39]  J. Laragh,et al.  Effect of corticotropin on aldosterone excretion and plasma renin in normal subjects, in essential hypertension and in primary aldosteronism. , 1968, The Journal of clinical endocrinology and metabolism.

[40]  R. E. Peterson,et al.  A New Form of Congenital Adrenal Hyperplasia1 , 1967 .

[41]  D. Sutherland,et al.  Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone. , 1966, Canadian Medical Association journal.

[42]  D. Sharma,et al.  Biosynthesis of C-18-oxygenated steroids by an aldosterone-secreting human adrenal tumor. Metabolism of [4-14C] progesterone, [1,2-3H]11-deoxycorticosterone, and [4-14C] pregnenolone. , 1965, Biochemistry.