Traumatic brain injury and neuro-endocrine disruption: medical and psychosocial rehabilitation.

INTRODUCTION Traumatic Brain Injury (TBI) initiates a cascade of neuromodulatory damage that blurs the distinctions between physical and psychological medicine. Monitoring endocrine function through labs is not part of the medical care algorithm for treatment of TBI, but the clinical symptoms are easily misidentified as they include: depression, fatigue, poor concentration, irritability and a decline in overall cognitive functioning. The reciprocal flow of change between neuroendocrine health and psychosocial health is well established within the field of neuroscience, social psychology, endocrinology and behavioral neurology, but has not translated into patient care. OBJECTIVES This paper outlines common neuroendocrine disruptions secondary to TBI and their clinical implications for treating mental health professionals. CONCLUSION Wider adoption of the consensus guidelines on the detection and monitoring of endocrine abnormalities post-TBI may diminish the severity of functional impairment and improve quality of life.

[1]  D. Arciniegas,et al.  The neuroendocrine effects of traumatic brain injury. , 2007, The Journal of neuropsychiatry and clinical neurosciences.

[2]  R. Miller,et al.  DIABETES INSIPIDUS FOLLOWING CLOSED HEAD INJURY , 1948, Journal of neurology, neurosurgery, and psychiatry.

[3]  K. Rexrode,et al.  High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women , 2012, PloS one.

[4]  J. Schmahmann.  Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. , 2004, The Journal of neuropsychiatry and clinical neurosciences.

[5]  David P. Friedman,et al.  The Signature of Maternal Rearing in the Methylome in Rhesus Macaque Prefrontal Cortex and T Cells , 2012, The Journal of Neuroscience.

[6]  C. Elwood,et al.  Traumatic partial hypopituitarism in a cat. , 2004, The Journal of small animal practice.

[7]  F. Penedo,et al.  Social influences on clinical outcomes of patients with ovarian cancer. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  C. Ruini,et al.  Life events in the pathogenesis of hyperprolactinemia. , 2004, European journal of endocrinology.

[9]  S. Cole,et al.  CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE Social Regulation of Human Gene , 2022 .

[10]  D. Pavlović,et al.  Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive disabilities and mental distress , 2004, Journal of endocrinological investigation.

[11]  S. Cole,et al.  Social Stress Desensitizes Lymphocytes to Regulation by Endogenous Glucocorticoids: Insights from In Vivo Cell Trafficking Dynamics in Rhesus Macaques , 2009, Psychosomatic medicine.

[12]  R. Jung.  Neuropsychological Assessment, 4th ed. , 2005 .

[13]  L. Hawkley,et al.  Loneliness and Health: Potential Mechanisms , 2002, Psychosomatic medicine.

[14]  Nicolas Rohleder,et al.  Chronic Interpersonal Stress Predicts Activation of Pro- and Anti-Inflammatory Signaling Pathways 6 Months Later , 2009, Psychosomatic medicine.

[15]  J. Douglas Bremner,et al.  Does stress damage the brain? , 1999, Biological Psychiatry.

[16]  S. Cole.  Social Threat, Personal Identity, and Physical Health in Closeted Gay Men. , 2006 .

[17]  J. M. Griffin,et al.  Diabetes insipidus caused by craniofacial trauma. , 1976, The Journal of trauma.

[18]  F. Casanueva,et al.  Traumatic brain injury as a relevant cause of growth hormone deficiency in adults: A KIMS-based study. , 2005, Archives of Physical Medicine and Rehabilitation.

[19]  S. Cole.  journal homepage: www.elsevier.com/locate/psyneuen INVITED REVIEW , 2010 .

[20]  Thomas C. Neylan,et al.  xaggerated neurobiological sensitivity to threat as a mechanism linking nxiety with increased risk for diseases of aging , 2012 .

[21]  R. Clemmons,et al.  Secondary hypoadrenocorticism associated with craniocerebral trauma in a dog. , 1999, Journal of the American Animal Hospital Association.

[22]  G. Gioia,et al.  Importance of 'return-to-learn' in pediatric and adolescent concussion. , 2012, Pediatric annals.

[23]  E. Keverne,et al.  Are subordinates always stressed? a comparative analysis of rank differences in cortisol levels among primates , 2003, Hormones and Behavior.

[24]  K. Lewis.  How do genes regulate simple behaviours? Understanding how different neurons in the vertebrate spinal cord are genetically specified , 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

[25]  J. D. Clark,et al.  Post‐Traumatic Hypopituitarism: SIX CASES AND A REVIEW OF THE LITERATURE , 1986, Medicine.

[26]  D. Hovda,et al.  The Neurometabolic Cascade of Concussion. , 2001, Journal of athletic training.

[27]  R. Sapolsky.  Social Status and Health in Humans and Other Animals , 2004 .

[28]  Serena Chen,et al.  Transference in social perception: the role of chronic accessibility in significant-other representations. , 1995, Journal of personality and social psychology.

[29]  Timothy E. Ham,et al.  Pituitary Dysfunction after Blast Traumatic Brain Injury: The UK BIOSAP Study , 2013, Annals of neurology.

[30]  B. Masel,et al.  Traumatic brain injury: a disease process, not an event. , 2010, Journal of neurotrauma.

[31]  K. Barrington.  The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs , 2001, BMC pediatrics.

[32]  W. Tormey,et al.  Acute glucocorticoid deficiency and diabetes insipidus are common after acute traumatic brain injury and predict mortality. , 2013, The Journal of clinical endocrinology and metabolism.

[33]  P P Urban,et al.  Different short‐term modulation of cortical motor output to distal and proximal upper‐limb muscles during painful sensory nerve stimulation , 2004, Muscle & nerve.

[34]  C. Cohan,et al.  Life course transitions and natural disaster: marriage, birth, and divorce following Hurricane Hugo. , 2002, Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association.

[35]  H. Lisser,et al.  Simmonds' Disease. A Clinical Study with Review of the Literature; Differentiation from Anorexia Nervosa by Statistical Analysis of 595 Cases, 101 of Which Were Proved Pathologically1 , 1942 .

[36]  Shelley E. Taylor,et al.  Social relationships and immune processes in HIV seropositive gay and bisexual men , 1997, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[37]  T. Neylan,et al.  Transcriptional Control of Monocyte Gene Expression in Post-Traumatic Stress Disorder , 2011, Disease markers.

[38]  K. Lesch,et al.  Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques , 2004, Biological Psychiatry.

[39]  Fisher Rs,et al.  Pituitary lesions in craniocerebral injuries. , 1969 .

[40]  A. Agha,et al.  Which patient requires neuroendocrine assessment following traumatic brain injury, when and how? , 2013, Clinical endocrinology.

[41]  J. Romijn,et al.  Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study. , 2011, European journal of endocrinology.

[42]  F. Casanueva,et al.  Hypopituitarism and Growth Hormone Deficiency in Adult Subjects after Traumatic Brain Injury: Who and When to Test , 2006, Pituitary.

[43]  T. Yeh,et al.  Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity. , 2004, The New England journal of medicine.

[44]  M. Marmot,et al.  Diabetes and cognitive function in a middle-aged cohort , 2005, Neurology.

[45]  E. Elovic,et al.  Consensus guidelines on screening for hypopituitarism following traumatic brain injury , 2005, Brain injury.

[46]  J. Schmahmann,et al.  The neuropsychiatry of the cerebellum — insights from the clinic , 2008, The Cerebellum.

[47]  B. Scheithauer,et al.  Histologic study of the human pituitary gland in acute traumatic brain injury , 2007, Brain injury.

[48]  S. Cole.  Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity , 2008, Brain, Behavior, and Immunity.

[49]  Matthew T. Sweney,et al.  Effects of Postnatal Dexamethasone Exposure on the Developmental Outcome of Premature Infants , 2008, Journal of child neurology.

[50]  Janet Wiles,et al.  Potential role for adult neurogenesis in the encoding of time in new memories , 2006, Nature Neuroscience.

[51]  P. Daniel,et al.  Traumatic infarction of the anterior lobe of the pituitary gland. , 1959, Lancet.

[52]  S. Cannavò,et al.  Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. , 2005, The Journal of clinical endocrinology and metabolism.

[53]  N. Charfi,et al.  [Post-traumatic hypopituitarism]. , 2001, Presse medicale.

[54]  Gregory Miller,et al.  Health psychology: developing biologically plausible models linking the social world and physical health. , 2009, Annual review of psychology.

[55]  F. Casanueva,et al.  Antipituitary antibodies after traumatic brain injury: is head trauma-induced pituitary dysfunction associated with autoimmunity? , 2008, European journal of endocrinology.

[56]  I. Dimopoulou,et al.  Diabetes Insipidus, Secondary Hypoadrenalism and Hypothyroidism after Traumatic Brain Injury: Clinical Implications , 2006, Pituitary.

[57]  G. Miller,et al.  Targeted Rejection Triggers Differential Pro- and Anti-Inflammatory Gene Expression in Adolescents as a Function of Social Status , 2013, Clinical psychological science : a journal of the Association for Psychological Science.

[58]  F. Trimarchi,et al.  Hypopituitarism Secondary to Head Trauma , 2000 .

[59]  J. Ghajar.  Traumatic brain injury , 2000, The Lancet.

[60]  S. Cole,et al.  Elevated physical health risk among gay men who conceal their homosexual identity. , 1996, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[61]  M. Sliwinski,et al.  Affective Reactivity to Daily Stressors and Long-Term Risk of Reporting a Chronic Physical Health Condition , 2013, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[62]  R. Galli,et al.  Neural Stem Cells: An Overview , 2003, Circulation research.

[63]  Bert N. Uchino,et al.  The relationship between social support and physiological processes: a review with emphasis on underlying mechanisms and implications for health. , 1996, Psychological bulletin.

[64]  T. Seeman,et al.  Computational identification of gene-social environment interaction at the human IL6 locus , 2010, Brain, Behavior, and Immunity.

[65]  Elizabeth Warren,et al.  Medical bankruptcy in the United States, 2007: results of a national study. , 2009, The American journal of medicine.

[66]  J. Altmann,et al.  Hypercortisolism associated with social subordinance or social isolation among wild baboons. , 1997, Archives of general psychiatry.

[67]  J. Herman,et al.  Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis , 1997, Trends in Neurosciences.

[68]  J. Langlois,et al.  Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths , 2006 .

[69]  F. Casanueva,et al.  Three years prospective investigation of anterior pituitary function after traumatic brain injury: a pilot study , 2008, Clinical endocrinology.

[70]  L. Dunkel,et al.  [Post-traumatic hypopituitarism]. , 1988, Duodecim; laaketieteellinen aikakauskirja.

[71]  S. Bernasconi,et al.  Posttraumatic anterior pituitary insufficiency in childhood. , 1979, Helvetica paediatrica acta.

[72]  J. Volpe.  Cerebellum of the Premature Infant: Rapidly Developing, Vulnerable, Clinically Important , 2009, Journal of child neurology.

[73]  F. Casanueva,et al.  Hypopituitarism following traumatic brain injury. , 2005, Frontiers of hormone research.

[74]  R. Swerdloff,et al.  Hypopituitarism following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a preliminary report. , 2000, Journal of neurosurgery.

[75]  Richard S. J. Frackowiak,et al.  Navigation-related structural change in the hippocampi of taxi drivers. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[76]  J. Phillips,et al.  Posterior pituitary dysfunction after traumatic brain injury. , 2004, The Journal of clinical endocrinology and metabolism.

[77]  M. Wald,et al.  Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths, 2002-2006 , 2010 .

[78]  S. Cole,et al.  Maternal Warmth Buffers the Effects of Low Early-Life Socioeconomic Status on Pro-Inflammatory Signaling in Adulthood , 2010, Molecular Psychiatry.

[79]  C. Carver,et al.  Cognitive-Behavioral Stress Management Reverses Anxiety-Related Leukocyte Transcriptional Dynamics , 2012, Biological Psychiatry.

[80]  T. Pentelényi.  Significance of endocrine studies in the general assessment and prediction of fatal outcome in head injury. , 1992, Acta neurochirurgica. Supplementum.

[81]  L. Hawkley,et al.  Social regulation of gene expression in human leukocytes , 2007, Genome Biology.

[82]  D. Powner,et al.  Adrenal insufficiency following traumatic brain injury in adults , 2008, Current opinion in critical care.

[83]  E A Maguire,et al.  Hippocampal involvement in human topographical memory: evidence from functional imaging. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[84]  R. Hamill,et al.  Thyroid test abnormalities in traumatic brain injury: correlation with neurologic impairment and sympathetic nervous system activation. , 1988, The American journal of medicine.

[85]  T. Bushnik,et al.  Fatigue after traumatic brain injury: Association with neuroendocrine, sleep, depression and other factors , 2010, Brain injury.

[86]  T. Najenson,et al.  Changes in life patterns and symptoms of low mood as reported by wives of severly brain-injured soldiers. , 1976, Journal of consulting and clinical psychology.

[87]  Matthew D. Lieberman,et al.  Does Rejection Hurt? An fMRI Study of Social Exclusion , 2003, Science.

[88]  J. Rosenfeld,et al.  Identifying factors contributing to child and family outcome 30 months after traumatic brain injury in children , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[89]  F. Casanueva,et al.  Hypopituitarism Following Traumatic Brain Injury: Determining Factors for Diagnosis , 2011, Front. Endocrin..

[90]  Michael R. Irwin,et al.  Reciprocal regulation of the neural and innate immune systems , 2011, Nature Reviews Immunology.

[91]  S. Rose,et al.  Endocrine changes after pediatric traumatic brain injury , 2012, Pituitary.

[92]  K. Kregel,et al.  Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. , 2002, Journal of applied physiology.

[93]  F. Casanueva,et al.  Boxing as a sport activity associated with isolated GH deficiency , 2004, Journal of endocrinological investigation.

[94]  N. Wray,et al.  Research review: the role of cytokines in depression in adolescents: a systematic review. , 2013, Journal of child psychology and psychiatry, and allied disciplines.

[95]  G. Robinson,et al.  Toward a new biology of social adversity , 2012, Proceedings of the National Academy of Sciences.

[96]  H. Kennerley,et al.  A Preliminary Study Examining Relationships Between Childhood Maltreatment, Dissociation, and Self-Injury in Psychiatric Outpatients , 2009, Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation.

[97]  F. Penedo,et al.  Depression, social support, and beta-adrenergic transcription control in human ovarian cancer , 2009, Brain, Behavior, and Immunity.

[98]  F. Gage,et al.  Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons , 2002, Nature Neuroscience.

[99]  W. R. Kiser,et al.  Psychiatric morbidity in adults with hypopituitarism. , 1995, Journal of the Royal Society of Medicine.

[100]  P. Iglesias,et al.  Selective growth hormone deficiency of hypothalamic origin following severe head injury , 1992, Acta paediatrica.

[101]  J. Olney,et al.  Acute neonatal glucocorticoid exposure produces selective and rapid cerebellar neural progenitor cell apoptotic death , 2008, Cell Death and Differentiation.

[102]  B. Masel,et al.  Effect of growth hormone replacement therapy on cognition after traumatic brain injury. , 2010, Journal of neurotrauma.

[103]  J. Phillips,et al.  The natural history of post-traumatic neurohypophysial dysfunction. , 2005, European journal of endocrinology.

[104]  S. Cole,et al.  Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous system , 2003, Biological Psychiatry.

[105]  J. Khoury,et al.  Hypopituitarism in pediatric survivors of inflicted traumatic brain injury. , 2014, Journal of Neurotrauma.

[106]  B. Masel.  Rehabilitation and hypopituitarism after traumatic brain injury. , 2004, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[107]  H. Levin,et al.  Neurobehavioral and quality of life changes associated with growth hormone insufficiency after complicated mild, moderate, or severe traumatic brain injury. , 2006, Journal of neurotrauma.

[108]  P. Faure,et al.  Secondary adrenal insufficiency in the acute phase of pediatric traumatic brain injury , 2010, Intensive Care Medicine.

[109]  M. Kaji,et al.  Acquired growth hormone deficiency due to pituitary stalk transection after head trauma in childhood , 1993, European Journal of Pediatrics.

[110]  B. Masel,et al.  Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. , 2001, The Journal of clinical endocrinology and metabolism.

[111]  S. Cannavò,et al.  Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: screening study at 3 months after the brain injury , 2004, Clinical endocrinology.

[112]  J. Phillips,et al.  Neuroendocrine dysfunction in the acute phase of traumatic brain injury , 2004, Clinical endocrinology.

[113]  S. Cole,et al.  A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB Signaling , 2008, Biological Psychiatry.

[114]  B. Masel,et al.  Anterior hypopituitarism following traumatic brain injury , 2005, Brain injury.

[115]  R. Clark,et al.  To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways , 2003, Progress in Neurobiology.