Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans
暂无分享,去创建一个
D. Galasko | T. Golde | E. Koo | I-Fang Ling
[1] M. Joyner,et al. Acute cyclooxygenase inhibition does not alter muscle sympathetic nerve activity or forearm vasodilator responsiveness in lean and obese adults , 2014, Physiological reports.
[2] T. Golde,et al. Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators , 2014, Biochemistry.
[3] T. Golde,et al. γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells* , 2013, The Journal of Biological Chemistry.
[4] T. Golde,et al. γ-Secretase inhibitors and modulators. , 2013, Biochimica et biophysica acta.
[5] D. Selkoe,et al. Gamma-secretase as a target for Alzheimer's disease therapy: Small-molecule development , 2013, Alzheimer's & Dementia.
[6] K. Bales,et al. γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin* , 2013, The Journal of Biological Chemistry.
[7] M. Takeda,et al. γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. , 2013, Cell reports.
[8] J. Dumin,et al. Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models , 2013, Alzheimer's Research & Therapy.
[9] R. Tanzi. The genetics of Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.
[10] T. Schneider-Axmann,et al. No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease , 2012, Neurobiology of Aging.
[11] Martin Knapp,et al. Donepezil and memantine for moderate-to-severe Alzheimer's disease. , 2012, The New England journal of medicine.
[12] S. Weggen,et al. Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells , 2012, PloS one.
[13] M. Wolfe. γ-Secretase as a target for Alzheimer's disease. , 2012, Advances in pharmacology.
[14] A. Iwai. [Gamma-secretase inhibitors and modulators]. , 2011, Nihon rinsho. Japanese journal of clinical medicine.
[15] S. Weggen,et al. Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer’s Disease , 2011, Current neuropharmacology.
[16] T. Iwatsubo,et al. Phenylpiperidine‐type γ‐secretase modulators target the transmembrane domain 1 of presenilin 1 , 2011, The EMBO journal.
[17] K. Bales,et al. Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1. , 2011, ACS chemical neuroscience.
[18] B. Strooper,et al. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics , 2011, Nature Reviews Drug Discovery.
[19] J. Morris,et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.
[20] Daniel Oehlrich,et al. γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs. , 2011, Journal of medicinal chemistry.
[21] Bryan Voss,et al. Pharmacokinetics, safety, and tolerability of a rapid infusion of i.v. ibuprofen in healthy adults. , 2011, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
[22] D. Selkoe. Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.
[23] J. Richardson,et al. TASTPM Mice Expressing Amyloid Precursor Protein and Presenilin-1 Mutant Transgenes Are Sensitive to γ-Secretase Modulation and Amyloid-β42 Lowering by GSM-10h , 2010, Neurodegenerative Diseases.
[24] S. C.A.,et al. Non-steroidal anti-inflammatory drugs and Alzheimer's disease: the epidemiological evidence. , 2010 .
[25] G. Cole,et al. Mechanisms of action of non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease. , 2010, CNS & neurological disorders drug targets.
[26] P. Zandi,et al. Non-steroidal anti-inflammatory drugs and Alzheimer's disease: the epidemiological evidence. , 2010, CNS & neurological disorders drug targets.
[27] Robert C Green,et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. , 2009, JAMA.
[28] B. Imbimbo. An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease , 2009, Expert opinion on investigational drugs.
[29] P. Pasqualetti,et al. A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer’s disease , 2009, Aging clinical and experimental research.
[30] E. Koo,et al. Amyloid Precursor Protein Trafficking, Processing, and Function* , 2008, Journal of Biological Chemistry.
[31] J. Wiltfang,et al. Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase* , 2008, Journal of Biological Chemistry.
[32] M. Wolfe,et al. Substrate-targeting γ-secretase modulators , 2008, Nature.
[33] P. Zandi,et al. No advantage of Aβ42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies , 2008, Neurology.
[34] Donald R. Miller,et al. Protective effects of NSAIDs on the development of Alzheimer disease , 2008, Neurology.
[35] B. Jenkins,et al. Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice , 2008, Brain Research.
[36] Richard M. Page,et al. Generation of Aβ38 and Aβ42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and γ-Secretase Modulation* , 2008, Journal of Biological Chemistry.
[37] Richard M. Page,et al. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. , 2008, The Journal of biological chemistry.
[38] E. Siemers,et al. Safety, Tolerability, and Effects on Plasma and Cerebrospinal Fluid Amyloid-&bgr; After Inhibition of &ggr;-Secretase , 2007 .
[39] D. Galasko,et al. Safety, Tolerability, Pharmacokinetics, and Aβ Levels After Short-term Administration of R-flurbiprofen in Healthy Elderly Individuals , 2007, Alzheimer disease and associated disorders.
[40] Patrick L. McGeer,et al. NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies , 2007, Neurobiology of Aging.
[41] J. Morris,et al. Fluctuations of CSF amyloid-β levels , 2007, Neurology.
[42] E. Siemers,et al. Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase. , 2007, Clinical neuropharmacology.
[43] T. Golde,et al. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice , 2007, BMC Neuroscience.
[44] T. Golde,et al. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. , 2006, The Journal of clinical investigation.
[45] T. Golde,et al. Anti-Aβ42– and anti-Aβ40–specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model , 2005 .
[46] L. Thal,et al. A Randomized, Double-Blind, Study of Rofecoxib in Patients with Mild Cognitive Impairment , 2005, Neuropsychopharmacology.
[47] C. Lines,et al. Rofecoxib , 2004, Neurology.
[48] L. Sansom,et al. Stereoselective plasma protein binding of ibuprofen enantiomers , 2004, European Journal of Clinical Pharmacology.
[49] Pritam Das,et al. NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo , 2003 .
[50] S. Motzel,et al. An alternative method of chronic cerebrospinal fluid collection via the cisterna magna in conscious rhesus monkeys. , 2003, Contemporary topics in laboratory animal science.
[51] K. Davis,et al. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. , 2003, JAMA.
[52] Pritam Das,et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. , 2003, The Journal of clinical investigation.
[53] D. Beher,et al. Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity , 2002 .
[54] J. Hardy,et al. The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .
[55] D. Coppola,et al. Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice , 2002, The Journal of Neuroscience.
[56] D. Beher,et al. Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity. , 2002, Journal of neurochemistry.
[57] Rong Wang,et al. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity , 2001, Nature.
[58] K. Ashe,et al. Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease , 2000, The Journal of Neuroscience.
[59] Šimon Scharf,et al. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease , 1999, Neurology.
[60] T. Morgan,et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[61] Weiming Xia,et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice , 1997, Nature Medicine.
[62] G. Schellenberg,et al. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease , 1996, Nature Medicine.
[63] J. Hardy,et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. , 1996, Nature medicine.
[64] P. Lansbury,et al. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. , 1993, Biochemistry.
[65] D. Jung,et al. Dose-dependent pharmacokinetics of ibuprofen in the rat. , 1987, Drug metabolism and disposition: the biological fate of chemicals.
[66] A. G. Zacchei,et al. STUDIES ON THE ABSORPTION, DISTRIBUTION AND EXCRETION OF INDOMETHACIN IN VARIOUS SPECIES , 1966 .
[67] A. Lbert,et al. Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease , 2022 .